首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   8693篇
  免费   840篇
  国内免费   15篇
耳鼻咽喉   52篇
儿科学   280篇
妇产科学   162篇
基础医学   1122篇
口腔科学   126篇
临床医学   949篇
内科学   1722篇
皮肤病学   97篇
神经病学   667篇
特种医学   344篇
外科学   1637篇
综合类   284篇
一般理论   26篇
预防医学   864篇
眼科学   78篇
药学   569篇
中国医学   52篇
肿瘤学   517篇
  2023年   55篇
  2022年   51篇
  2021年   126篇
  2020年   120篇
  2019年   177篇
  2018年   204篇
  2017年   150篇
  2016年   164篇
  2015年   163篇
  2014年   247篇
  2013年   357篇
  2012年   534篇
  2011年   519篇
  2010年   292篇
  2009年   289篇
  2008年   498篇
  2007年   456篇
  2006年   410篇
  2005年   445篇
  2004年   397篇
  2003年   341篇
  2002年   322篇
  2001年   241篇
  2000年   263篇
  1999年   220篇
  1998年   121篇
  1997年   96篇
  1996年   115篇
  1995年   80篇
  1994年   102篇
  1993年   84篇
  1992年   127篇
  1991年   158篇
  1990年   107篇
  1989年   107篇
  1988年   129篇
  1987年   146篇
  1986年   126篇
  1985年   114篇
  1984年   74篇
  1983年   61篇
  1982年   45篇
  1980年   54篇
  1979年   68篇
  1978年   50篇
  1977年   60篇
  1976年   44篇
  1975年   44篇
  1974年   49篇
  1972年   42篇
排序方式: 共有9548条查询结果,搜索用时 15 毫秒
1.
2.
3.
Rhinovirus (RV) infections are linked to the development and exacerbation of allergic diseases including allergic asthma. IgE, another contributor to atopic disease pathogenesis, has been shown to regulate DC antiviral functions and influence T cell priming by monocytes. We previously demonstrated that IgE-mediated stimulation of monocytes alters multiple cellular functions including cytokine secretion, phagocytosis, and influenza-induced Th1 development. In this study, we investigate the effects of IgE-mediated stimulation on monocyte-driven, RV-induced T cell development utilizing primary human monocyte-T cell co-cultures. We demonstrate that IgE crosslinking of RV-exposed monocytes enhances monocyte-driven Th2 differentiation. This increase in RV-induced Th2 development was regulated by IgE-mediated inhibition of virus-induced type I IFN and induction of IL-10. These findings suggest an additional mechanism by which two clinically significant risk factors for allergic disease exacerbations—IgE-mediated stimulation and rhinovirus infection—may synergistically promote Th2 differentiation and allergic inflammation.  相似文献   
4.
5.
On September 11, 2001 two hijacked airplanes struck the Twin Towers at the World Trade Center in New York City. All of the remains (19,915) were examined by the Office of Chief Medical Examiner (OCME) of New York City. The major goals of the OCME were to accurately identify the decedents and to promptly issue death certificates. As of September 2005, there were 1594 identifications of a total of 2749 people reported missing. Of these, 976 were identified by a single means, which included DNA analysis in 852 of the victims. Use of legal statues can assist in the timely issuance of death certificates in mass fatalities, which benefit surviving family members. DNA analysis markedly improves the ability to identify remains and has become the standard method for identification in these types of disasters. Certain postmortem tissue samples are better suited for DNA analysis and yield better results than others.  相似文献   
6.
7.
8.
The current experience of a high dependency unit established 5 years ago for the postoperative care of high-risk patients undergoing surgery is reported. The resource implications and contributions to the safety and quality of post-operative care, particularly pain relief, are described.  相似文献   
9.
Purpose Parathyroid carcinoma (PC) is rare and accounts for less than 1% of all cases of primary hyperparathyroidism (PHPT). The definitive histopathologic diagnosis of PC requires unequivocal invasion or metastasis which may be absent at first presentation. As a result, many cases of PC can only be diagnosed retrospectively. Parafibromin is the protein encoded by HRPT2 which is mutated and not expressed in many parathyroid carcinomas. Given that PCs generally weigh more than parathyroid adenomas (PA)s, we hypothesized that amongst large PAs there may be a high incidence of occult PC which could be identified by negative staining for parafibromin. Methodology 57 parathyroid glands weighing greater than 2 grams excised from 1998–2006 were identified from the University of Sydney Endocrine Surgical Database. Two specimens with a histopathologic diagnosis of PC were excluded. Immunohistochemical staining for parafibromin was performed on the remaining 55 PAs. Results Of the 55 specimens stained for parafibromin only one definite negative stain was detected. This case was originally classified as an “atypical adenoma” because it showed nuclear and architectural atypia without unequivocal evidence of invasive growth. In view of the negative staining for parafibromin it therefore probably represents occult carcinoma. There has been no evidence of recurrence or metastasis after 6.5 years. Conclusions Complete loss of staining for parafibromin is very rare in giant parathyroid adenomas suggesting that occult carcinoma is equally rare. As a result routine immunohistochemical staining for parafibromin does not appear to be an effective screening test for carcinoma in large PA without histopathologic features of PC.  相似文献   
10.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号