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One-Year Follow-up of Duodenal Ulcers after 1-Wk Triple Therapy for Helicobacter pylori 总被引:1,自引:0,他引:1
Joseph J. Y. Sung M.D. S.C. Sydney Chung M.D. Thomas K. VV. Ling Ph.D. Man Yee Yung R.N. Augustin F. B. Cheng M.D. Shorland W. Hosking M.D. Arthur K. C. Li M.D. 《The American journal of gastroenterology》1994,89(2):199-202
Objective : to study the ulcer recurrence rate of Helicobacter pylori-positive duodenal ulcers at 1 yr after eradication of the bacteria by triple therapy. Method : Patients with H. pylori-positive duodenal ulcers were randomized to receive either triple therapy for 1 wk plus omeprazole for 4 wk (THple+OMP) (n = 78), or omeprazole alone (OMP) for 4 wk (N = 77). Patients were followed up every 3 months for symptom enquiry. At 1 yr, all asymptomatic patients were invited to attend for gastroscopy. Results : At 8 wk, 16 patients in the OMP group and four in the Triple+OMP group had an ulcer. During the 1-yr period, 12 patients in the OMP group and no patient in the Triple+OMP group developed symptomatic ulcers. At follow-up endoscopy at 1 yr, another 10 ulcers were detected in the OMP group and two in the Triple+OMP group. Fifteen patients in the OMP group and 13 in the Triple+OMP group were lost to follow-up. In total, ulcers were de-tected in 39 of 61 (64%) assessahle patients in the OMP group, and in six of 65 (97o) assessahle patients in the Triple+OMP group after I yr (χ2 test: p < 0.001). Of the patients whose H, pytori were successfully eradicated hy Triple+OMP at 8 wk, 90% remained H. pylori negative at 1 yr. Conclusion : Triple therapy for 1 wk eradicates H, pylori infection and significantly reduces duodenal ulcer relapses. 相似文献
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H Havanka-Kanniainen E Hokkanen VV Myllylä 《Cephalalgia : an international journal of headache》1985,5(1):39-43
The efficacy of nimodipine in the prophylaxis of migraine was assessed in a double-blind, placebo-controlled, cross-over study carried out on 33 patients, 20 of whom suffered from classic and 13 from common migraine. Four patients dropped out, but not as a result of the side effects of the drug. The duration of drug treatment was 8 weeks. The dosage used was 30 mg four times daily. Nimodipine proved to be better than placebo, the number of migraine attacks and severity of headache showing a significant reduction. The drug was well tolerated and no marked side effects were noted. The results suggest that nimodipine is a useful new prophylactic drug for migraine, but further studies are needed before its final value can be evaluated. 相似文献
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Halbach VV; Higashida RT; Hieshima GB; Reicher M; Norman D; Newton TH 《Radiology》1987,163(2):437-442
Thirty symptomatic indirect carotid cavernous fistulas were treated between 1978 and 1986 with a variety of treatment modalities. Combined carotid artery and jugular vein compression resulted in a complete cure in seven of 23 patients (30%) and improvement in one additional patient. There were no complications from this treatment, which is performed by the patient on an outpatient basis. Patients in whom carotid jugular compression therapy failed or who demonstrated cortical venous drainage or visual decline were treated with intravascular embolization. Embolization resulted in complete cure in 17 of 22 (77%) and improvement in four of 22 (18%). One patient required surgical excision of the involved dura after embolization to achieve complete cure. There was one permanent complication (stroke), which resulted in mild weakness caused by clot formation on a catheter. 相似文献
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De Lorenzo F; Xiao H; Mukherjee M; Harcup J; Suleiman S; Kadziola Z; Kakkar VV 《QJM : monthly journal of the Association of Physicians》1998,91(7):475-481
We investigated whether chronic fatigue syndrome (CFS) patients have
physical and/or cardiovascular de-conditioning, in 273 CFS patients and 72
healthy controls. We used laboratory tests to assess haematological,
biochemical, endocrinological and immunological systems. The cardiovascular
system was assessed by echocardiography and carotid echography. Body
composition was determined by dual energy X-ray absorptiometry (DEXA). CFS
patients had smaller left ventricular end systolic (p < 0.001) and
diastolic (p = 0.008) dimensions but thinner posterior walls (p = 0.02)
than corresponding values in healthy controls. Left ventricular mass was
also reduced in CFS patients (p = 0.006). Both maximum (p < 0.001) and
minimum (p < 0.008) diameter of the carotid artery were smaller in CFS
patients. The laboratory screening tests showed significant differences in
serum albumin (p = 0.05), phosphate (p = 0.02), HDL-cholesterol (p = 0.03),
HDL:total cholesterol ratio (p = 0.01), triglycerides (p = 0.02),
neutrophils (p = 0.01) and thyroid-stimulating hormone (p = 0.04) between
CFS patients and controls. Male CFS patients had an increased percentage of
fat mass compared with healthy male subjects (p = 0.02). This large group
of CFS patients had evidence of physical and cardiovascular
de-conditioning, suggesting that in these patients a graded exercise
programme could lead to physical reconditioning and could increase their
ability to perform physical activities.
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