全文获取类型
收费全文 | 59785篇 |
免费 | 6467篇 |
国内免费 | 140篇 |
专业分类
耳鼻咽喉 | 618篇 |
儿科学 | 1708篇 |
妇产科学 | 1353篇 |
基础医学 | 8451篇 |
口腔科学 | 1209篇 |
临床医学 | 7035篇 |
内科学 | 10942篇 |
皮肤病学 | 747篇 |
神经病学 | 5655篇 |
特种医学 | 2113篇 |
外国民族医学 | 59篇 |
外科学 | 9131篇 |
综合类 | 1155篇 |
一般理论 | 53篇 |
预防医学 | 6181篇 |
眼科学 | 2110篇 |
药学 | 4419篇 |
中国医学 | 46篇 |
肿瘤学 | 3407篇 |
出版年
2023年 | 444篇 |
2021年 | 940篇 |
2020年 | 596篇 |
2019年 | 895篇 |
2018年 | 1195篇 |
2017年 | 1000篇 |
2016年 | 1030篇 |
2015年 | 1129篇 |
2014年 | 1542篇 |
2013年 | 2276篇 |
2012年 | 3054篇 |
2011年 | 3071篇 |
2010年 | 1833篇 |
2009年 | 1639篇 |
2008年 | 2736篇 |
2007年 | 2795篇 |
2006年 | 2787篇 |
2005年 | 2710篇 |
2004年 | 2656篇 |
2003年 | 2370篇 |
2002年 | 2293篇 |
2001年 | 1646篇 |
2000年 | 1744篇 |
1999年 | 1523篇 |
1998年 | 776篇 |
1997年 | 668篇 |
1996年 | 578篇 |
1995年 | 612篇 |
1994年 | 587篇 |
1993年 | 493篇 |
1992年 | 1218篇 |
1991年 | 1231篇 |
1990年 | 1120篇 |
1989年 | 1132篇 |
1988年 | 1118篇 |
1987年 | 928篇 |
1986年 | 947篇 |
1985年 | 930篇 |
1984年 | 786篇 |
1983年 | 652篇 |
1982年 | 459篇 |
1981年 | 424篇 |
1979年 | 715篇 |
1978年 | 559篇 |
1977年 | 471篇 |
1976年 | 439篇 |
1975年 | 400篇 |
1974年 | 462篇 |
1973年 | 465篇 |
1972年 | 407篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Heather L. Brown 《Journal of emergency nursing》2021,47(2):321-325
The coronavirus 2019 pandemic has affected almost every aspect of health care delivery in the United States, and the emergency medicine system has been hit particularly hard while dealing with this public health crisis. In an unprecedented time in our history, medical systems and clinicians have been asked to be creative, flexible, and innovative, all while continuing to uphold the important standards in the US health care system. To continue providing quality services to patients during this extraordinary time, care providers, organizations, administrators, and insurers have needed to alter longstanding models and procedures to respond to the dynamics of a pandemic. The Emergency Medicine Treatment and Active Labor Act of 1986, or EMTALA, is 1 example of where these alterations have allowed health care facilities and clinicians to continue their work of caring for patients while protecting both the patients and the clinicians themselves from infectious exposures at the same time. 相似文献
2.
3.
There is a sharp difference in how one views TCR structure–function–behaviour dependent on whether its recognition of major histocompatibility complex‐encoded restriction elements (R) is germline selected or somatically generated. The generally accepted or Standard model is built on the assumption that recognition of R is by the V regions of the αβ TCR, which is not driven by allele specificity, whereas the competing model posits that recognition of R is allele‐specific. The establishing of allele‐specific recognition of R by the TCR would rule out the Standard model and clear the road to a consideration of a competing construct, the Tritope model. Here, the case for allele‐specific recognition (germline selected) is detailed making it obvious that the Standard model is untenable. 相似文献
4.
Osric A. Forrest Daniel M. Chopyk Yael Gernez Milton R. Brown Carol K. Conrad Richard B. Moss Vin Tangpricha Limin Peng Rabindra Tirouvanziam 《Journal of cystic fibrosis》2019,18(1):64-70
Background
Resistin is an immunometabolic mediator that is elevated in several inflammatory disorders. A ligand for Toll-like receptor 4, resistin modulates the recruitment and activation of myeloid cells, notably neutrophils. Neutrophils are major drivers of cystic fibrosis (CF) lung disease, in part due to the release of human neutrophil elastase- and myeloperoxidase-rich primary granules, leading to tissue damage. Here we assessed the relationship of resistin to CF lung disease.Methods
Resistin levels were measured in plasma and sputum from three retrospective CF cohorts spanning a wide range of disease. We also assessed the ability of neutrophils to secrete resistin upon activation in vitro. Finally, we constructed a multivariate model assessing the relationship between resistin levels and lung function.Results
Plasma resistin levels were only marginally higher in CF than in healthy control subjects. By contrast, sputum resistin levels were very high in CF, reaching 50–100 fold higher levels than in plasma. Among CF patients, higher plasma resistin levels were associated with allergic bronchopulmonary aspergillosis, and higher sputum resistin levels were associated with CF-related diabetes. Mechanistically, in vitro release of neutrophil primary granules was concomitant with resistin secretion. Overall, sputum resistin levels were negatively correlated with CF lung function, independently of other variables (age, sex, and genotype).Conclusions
Our data establish relationships between resistin levels in the plasma and sputum of CF patients that correlate with disease status, and identify resistin as a novel mechanistic link between neutrophilic inflammation and lung disease in CF. 相似文献5.
6.
7.
Wai Man Mandy Chan Yik Weng Yew Thiam Seng Colin Theng Choon Fong Liew Hazel H Oon 《Singapore medical journal》2020,61(4):194
INTRODUCTIONPsoriasis is a chronic inflammatory condition that affects the skin and joints, and is associated with cardiovascular risk factors, including metabolic syndrome (MetS). We aimed to assess the prevalence of MetS in patients with psoriasis and determine whether there was a correlation between psoriasis severity and MetS in a Singapore population.METHODSThis was a cross-sectional study of patients with psoriasis, aged 18–69 years, who attended a tertiary dermatology referral centre in Singapore from October 2007 to February 2009. Fasting glucose, lipids, blood pressure, Psoriasis Area and Severity Index, and body mass index were measured. MetS was diagnosed in the presence of three or more criteria of the modified National Cholesterol Education Program Adult Treatment Panel III.RESULTSAmong 338 patients with psoriasis, there were 238 (70.4%) men and 100 (29.6%) women, who were Chinese (n = 228; 67.5%), Malay (n = 52; 15.4%) and Indian (n = 58; 17.2%). The prevalence of MetS was 45.1%. MetS was 44% more prevalent in patients older than 50 years (p = 0.02). Malay patients with psoriasis were significantly more likely to have hypertriglyceridaemia, elevated fasting plasma glucose and abdominal obesity. There was no significant correlation between psoriasis severity and risk of MetS.CONCLUSIONThe prevalence of MetS in patients with psoriasis in Singapore was 45.1%, or nearly threefold higher than the Singapore general population. Patients with psoriasis should be screened yearly for MetS and any modifiable cardiovascular risk factors should be actively controlled. 相似文献
8.
9.
10.
Characteristics of hyperparathyroid states in the Canadian multicentre osteoporosis study (CaMos) and relationship to skeletal markers
下载免费PDF全文
![点击此处可从《Clinical endocrinology》网站下载免费的PDF全文](/ch/ext_images/free.gif)