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本文综述了抗抑郁药所致性功能障碍的发病率、作用机制及应对策略.  相似文献   
3.
目的 调查山西省65~74岁人群牙周健康率、牙石、牙龈出血、牙周袋、附着丧失、无牙颌及存留牙等指标的检出情况,以了解山西省老年人的牙周健康状况与牙周炎的流行病学特征.方法 采用多阶段等容量随机抽样抽取山西省898名65~74岁老年人,内容包括基本信息、问卷调查、口腔检查与体格检查,口腔检查主要包括牙周健康率、牙石、牙龈...  相似文献   
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提高老年病人的护理质量,要注重做好老年病人的心理护理.根据老年病人的心理变化、心理特征、悲观情绪、孤独、猜疑、自制力下降、易怒及暴躁情绪等一系列心理分析,给予了相应的护理措施,针对性进行心理护理,加强护士为病人服务的意识,更新护理观念,建立良好的护患关系,加强护士自身修养及老年患者的健康教育宣传工作,尊重病人人格,善于运用沟通技巧.以护理程序为框架为老年病人开展系统的心理护理,达到了更好的护理效果.认为心理护理是老年病人整体护理工作重要的组成部分,能减少并发症和疾病的复发,促进疾病康复.  相似文献   
5.
AO钛制弹性髓内钉治疗儿童桡骨颈骨折16例   总被引:1,自引:0,他引:1  
目的探讨儿童桡骨颈骨折的治疗方法和疗效。方法对16例A、C型儿童桡骨颈骨折采取闭合复位、小切口AO钛制弹性髓内钉内固定治疗。结果 16例随访6~12个月,全部骨性愈合,愈合时间为2~3个月,平均9周。术后10周完全恢复肘关节功能无严重的并发症发生。结论 AO钛制弹性髓内钉闭合复位内固定治疗儿童桡骨颈骨折,安全、微创、固定可靠,可尽早恢复功能活动,愈合快,并发症少。  相似文献   
6.
Objective To investigate the effects of butorphanol pretreatment on myocardial ischemia-reperfusion (IR) injury in rats. Methods Forty healthy male SD rats weighing 200-250 g were randomly divided into 5 groups (n = 8 each) : sham operation group (group S); IR group; butorphanol pretreatment group (group B); Nor-BNI group (group N) and glibenclamide group (group G) . In group IR, B, N and G, myocardial IR was produced by occlusion of left anterior descending artery (LAD) for 30 min followed by 120 min reperfusion. In group S and IR, normal saline S ml/kg was injected via femoral vein 10 min before ischemia and then continuously infused at a rate of 5 ml· kg -1· h-1 iv. In group B, butorphanol 25 μg/kg was injected via femoral vein 10 min before ischemia and the rest method was the same as that described in group IR. In group N, Nor-BNI 2 mg/kg (a selective κ-opioid receptor antagonist) was injected via femoral vein 20 min before ischemia and the rest method was the same as that described in group B. In group G, glibenclamide 1 mg/kg (a KATP channel blocker) was injected via femoral vein 10 min before ischemia and the rest method was the same as that described in group B. Blood samples were taken from femoral artery at 120 min of reperfusion for determination of the concentrations of serum TNF-α, IL-6 and IL-10 by ELISA. Myocardial infarct area and ischemic area were measured by TTC staining and myocardial infarct size was calculated. Results The concentrations of serum TNF-a, IL-6 and IL-10 were significantly higher in the other four groups than in group S (P < 0.05) . The concentrations of serum TNF-α andIL-6 were significantly decreased while IL-10 increased, and the myocardial infarct size was significantly decreased in group B, N and G as compared with group IR ( P < 0.05) . The concentrations of serum TNF-α and IL-6 were significantly increased while the concentration of IL-10 decreased) and the myocardial infarct size was significantly increased in group N and G as compared with group B ( P < 0.05). Conclusion Butorphanol pretreatment can protect the myocardium against IR injury in rate via activating κ receptor and KATP channel.  相似文献   
7.
<正>腹主动脉夹层(abdominal aortic dissection,AAD)是累及膈肌水平以下主动脉的夹层,依其发病机制分为两型:一种是孤立性腹主动脉夹层(isolated abdominal aortic dissection,IAAD),临床较少见,破口位于腹  相似文献   
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目的 探讨布托啡诺预先给药对大鼠心肌缺血再灌注损伤的影响.方法 健康雄性SD大鼠40只,体重200~250 g,随机分为5组,每组8只.假手术组(S组)开胸暴露心脏,左冠状动脉前降支仅穿线但不结扎;缺血再灌注组(IR组)结扎左冠状动脉前降支30 min,再灌注120 min;S组和IR组于缺血前10 min经股静脉注射生理盐水5ml/kg,随后以5 ml·kg-1·h-1的速率静脉输注;布托啡诺预先给药组(B组)缺血前10 min经股静脉注射布托啡诺25μg/kg,余处理同IR组;Nor-BNI组(N组)缺血前20 min经股静脉注射选择性K受体阻断剂Nor-BNI 2 mg/kg,余处理同B组;格列本脲组(G组)缺血前10 min经股静脉注射KATP通道阻滞剂格列本脲1 mg/kg,余处理同B组.于再灌注120 min时取股动脉血样,采用ELISA法测定血清肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)和IL-10的浓度;采用TTC染色法测定心肌梗死区及心肌缺血区,计算心肌梗死面积.结果 与S组比较,其余各组血清TNF-α、IL-6和IL-10浓度升高(P<0.05);与IR组比较,B组、N组和G组血清TNF-α、IL-6浓度降低,IL-10浓度升高,心肌梗死面积减小(P<0.05);与B组比较,N组和G组血清TNF-α、IL-6浓度升高,IL-10浓度降低,心肌梗死面积增加(P<0.05).结论 布托啡诺预先给药可减轻大鼠心肌缺血再灌注损伤,可能与激活κ受体和KATP通道有关.  相似文献   
10.
Objective To investigate the effects of butorphanol pretreatment on myocardial ischemia-reperfusion (IR) injury in rats. Methods Forty healthy male SD rats weighing 200-250 g were randomly divided into 5 groups (n = 8 each) : sham operation group (group S); IR group; butorphanol pretreatment group (group B); Nor-BNI group (group N) and glibenclamide group (group G) . In group IR, B, N and G, myocardial IR was produced by occlusion of left anterior descending artery (LAD) for 30 min followed by 120 min reperfusion. In group S and IR, normal saline S ml/kg was injected via femoral vein 10 min before ischemia and then continuously infused at a rate of 5 ml· kg -1· h-1 iv. In group B, butorphanol 25 μg/kg was injected via femoral vein 10 min before ischemia and the rest method was the same as that described in group IR. In group N, Nor-BNI 2 mg/kg (a selective κ-opioid receptor antagonist) was injected via femoral vein 20 min before ischemia and the rest method was the same as that described in group B. In group G, glibenclamide 1 mg/kg (a KATP channel blocker) was injected via femoral vein 10 min before ischemia and the rest method was the same as that described in group B. Blood samples were taken from femoral artery at 120 min of reperfusion for determination of the concentrations of serum TNF-α, IL-6 and IL-10 by ELISA. Myocardial infarct area and ischemic area were measured by TTC staining and myocardial infarct size was calculated. Results The concentrations of serum TNF-a, IL-6 and IL-10 were significantly higher in the other four groups than in group S (P < 0.05) . The concentrations of serum TNF-α andIL-6 were significantly decreased while IL-10 increased, and the myocardial infarct size was significantly decreased in group B, N and G as compared with group IR ( P < 0.05) . The concentrations of serum TNF-α and IL-6 were significantly increased while the concentration of IL-10 decreased) and the myocardial infarct size was significantly increased in group N and G as compared with group B ( P < 0.05). Conclusion Butorphanol pretreatment can protect the myocardium against IR injury in rate via activating κ receptor and KATP channel.  相似文献   
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