人脐带间充质干细胞联合抗病毒等方法治疗新型冠状病毒肺炎

目的探讨人脐带间充质干细胞(hUCMSC)联合抗病毒等方法对新型冠状病毒肺炎(COVID-19重症患者的治疗作用。方法在常规治疗的基础上,对1例70岁的女性COVID-19重症患者静脉输注三次异体人脐带间充质干细胞,并对其抑制炎症反应和组织损伤的作用进行研究。结果降低了主要炎症因子IL-6以及C-反应蛋白(CRP)等指标的水平,输注期间患者中性粒细胞与淋巴细胞的比值持续下降,T细胞、NK细胞和B细胞的绝对值持续回升,CT影像结果显示肺部的炎症反应逐渐消退;未见不良反应。结论异体人脐带间充质干细胞联合抗病毒等方法对COVID-19重症患者安全有效,值得进行更多的临床探索。     

藏药“佐太”长期给药对大鼠肾脏潜在氧化损伤的初步研究

目的:初步探讨长期给予藏药"佐太"对大鼠肾脏可能存在的氧化损伤,以期揭示藏药"佐太"长期用药对肾脏可能存在的过氧化毒性作用,为"佐太"制剂在临床上的安全合理使用提供一定的理论依据。方法:将120只SD大鼠随机分为空白对照组和藏药"佐太"高、中、低剂量组,通过对大鼠给予"佐太"混悬液90天、180天及停药恢复30天,对动物进行一般观察,检测大鼠肾脏中丙二醛(MDA)含量和超氧化物歧化酶(SOD)活性,计算其肾脏系数并进行肾组织病理学检查。结果:连续给药"佐太"90天、180天及停药30天后,与空白对照组比较,藏药"佐太"各给药组大鼠外观体征、行为活动、进食及排便情况均无明显异常,各给药组大鼠肾脏中MDA含量、SOD活性、肾脏系数及肾组织病理学与空白对照组比较均无明显差异(P0.05)。结论:推测长期使用藏药"佐太"对大鼠肾脏不产生明显的氧化损伤和肾脏毒性作用,但其安全性问题仍然需要广泛而深入地研究。     

人类精液收集与处理技术改进

辅助生殖技术中精子的准备是极其重要的一个环节.采集并分离得到高活力的精子是保证受孕成功的关键步骤,而精液的冷冻贮存是延续生育力的重要手段之一.目前,精子采集方法,各种精子分离技术和冷冻方式已广泛被临床采用.本文主要就从精液样本的采集、精子优选技术以及精液的冷冻贮存方式进行探讨.     

吸入性损伤致气管狭窄并发窒息一例

患者男 ,34岁 ,火焰烧伤伴重度吸入性损伤 ,烧伤面积5 3 %ＴＢＳＡ ,Ⅱ度 33 %ＴＢＳＡ ,Ⅲ度 2 0 %ＴＢＳＡ。 3ｈ后入院 ,即行气管切开术。给予常规抗休克、抗感染及切削痂植皮手术等治疗。气管切开持续 2 5ｄ ,期间并发肺炎 ,经抗感染治疗后缓解。住院 5 5ｄ烧伤创面基本愈合出院。出院后 7ｄ(伤后 6 2ｄ) ,因受凉出现咳嗽、咯痰、喘息等症状 ,4ｄ后病情加重再次入院。查体 :意识清楚 ,心率 90次 /ｍｉｎ ,呼吸 2 3次 /ｍｉｎ ,血压 12 0 / 70ｍｍＨｇ(1ｍｍＨｇ =0 133ｋＰａ)。全身散在肉芽创面。咽部充血 ,呼吸费力 ,胸骨上窝、胸骨…     

肝内胆管结石症行肝脏移植（附1例报告）

目的 探讨肝内胆管结石症作为肝移植指征之一的可行性及合理性。方法 对1例28岁男性患广泛弥漫性肝内胆管结石并胆汁性肝硬变的患者进行原位肝移植。结果 移植后恢复良好,已出院,无术后感染发生。结论 肝内胆管结石作为肝移植指征是可行的、安全的。     

带针钢丝张力带内固定治疗髌骨骨折

髌骨骨折 ,目前多采用张力带钢丝内固定术 ,效果较好。然而部分内固定后有脱针、克氏针尾留置过长 ,甚至刺穿皮肤 ,影响关节活动及引起局部感染而提前取出内固定材料。我院近 4年来对 9例髌骨骨折 ,采用了带针鼻张力带钢丝内固定术 ,取得较好的临床效果 ,且无一例并发症 ,报告如下。1　临床资料本组男 6例 ,女 3例。年龄 14～ 5 4岁。闭合伤 7例 ,刀砍伤 2例 ,均为髌骨横形骨折。手术固定方法与张力带钢丝内固定术方法相同 ,不同之处为 2枚直径 2 mm ,尾部有孔的克氏针分别反方向固定髌骨 ,针孔直径约大于 0 .8mm ,距髌骨上下缘约 0 .3m m ,…     

螺旋CT和彩色多普勒血流显像检查对胰腺癌可切除性的评估价值

Objective To determine the value of helical computed tomography (HCT) and color doppler flowing imaging (CDPI) in evaluating the resectability of pancreatic cancer. Methods The clinical data of 114 patients with pancreatic cancer who had been admitted to the Affiliated Hospital of North Sichuan Medical College from January 1995 to December 2002 were retrospectively analyzed. The values of HCT and CDPI in assessing the resectability of pancreatic cancer were determined according to the results of operation and pathological examina-tion. All the data were analyzed by chi-square test and Fisher exact probability. Results Of all patients, 109 were examined by HCT, 97 by CDPI and 96 by HCT+CDPI. For patients examined by HCT, the resection rates of pancreatic head cancer, pancreatic body and tail cancer and total pancreatic cancer were 45.3% (39/86), 26.3% (5/19) and 0 (0/9), respectively. The resection rate of pancreatic head cancer was higher than that of pancreatic body and tail cancer (χ2=8.965, P<0.05). With the increase of tumor size, the invasion rate and metastasis rate were increased and the resection rate was decreased (z=6.15, 5.35, 7.18, P<0.01). The sensitivity rate and specificity rate were 77.8% and 82.2% of HCT, 73.3% and 80.6% of CDPI, 90.6% and 92.4% of HCT+CDPI in assessing the resectability of pancreatic cancer. The values of Kappa identity test of HCT, CDPI and HCT+CDPI were 0.58, 0.52 and 0.82, respectively. Conclusions Combined application of HCT and CDPI can further improve the accuracy in assessing the resectability of pancreatic cancer.     

三子养亲汤与二陈汤联合对哮喘急性发作期的应用效果研究

目的研究三子养亲汤与二陈汤联合对哮喘急性发作期的应用效果。方法研究数据选择2017年1月至2018年5月在本院接受治疗的哮喘急性发作期70例为基础数据,按照随机方式进行平均分组(对照组n=35,观察组n=35),对照组应用氯雷他定药物治疗,观察组使用三子养亲汤与二陈汤联合治疗,对比肺部功能恢复指标以及不良反应率。结果观察组FEV_1、FEV_1/FVC、PEF肺功能各项指标均高于对照组,观察组不良反应率与对照组进行比较,整体发生率下降较为明显,P0.05。结论哮喘急性发作期采用三子养亲汤联合二陈汤治疗的方式,可以对患者的症状进行更加有效的缓解,保证药物治疗的效果,促进患者恢复,整体效果较为理想,可作为治疗的重要方法在临床范围内进行推广普及。     

螺旋CT和彩色多普勒血流显像检查对胰腺癌可切除性的评估价值

Objective To determine the value of helical computed tomography (HCT) and color doppler flowing imaging (CDPI) in evaluating the resectability of pancreatic cancer. Methods The clinical data of 114 patients with pancreatic cancer who had been admitted to the Affiliated Hospital of North Sichuan Medical College from January 1995 to December 2002 were retrospectively analyzed. The values of HCT and CDPI in assessing the resectability of pancreatic cancer were determined according to the results of operation and pathological examina-tion. All the data were analyzed by chi-square test and Fisher exact probability. Results Of all patients, 109 were examined by HCT, 97 by CDPI and 96 by HCT+CDPI. For patients examined by HCT, the resection rates of pancreatic head cancer, pancreatic body and tail cancer and total pancreatic cancer were 45.3% (39/86), 26.3% (5/19) and 0 (0/9), respectively. The resection rate of pancreatic head cancer was higher than that of pancreatic body and tail cancer (χ2=8.965, P<0.05). With the increase of tumor size, the invasion rate and metastasis rate were increased and the resection rate was decreased (z=6.15, 5.35, 7.18, P<0.01). The sensitivity rate and specificity rate were 77.8% and 82.2% of HCT, 73.3% and 80.6% of CDPI, 90.6% and 92.4% of HCT+CDPI in assessing the resectability of pancreatic cancer. The values of Kappa identity test of HCT, CDPI and HCT+CDPI were 0.58, 0.52 and 0.82, respectively. Conclusions Combined application of HCT and CDPI can further improve the accuracy in assessing the resectability of pancreatic cancer.     

肝移植术后再次腹部手术(附7例报告)

目的探讨肝移植术后再次腹部手术的围手术期处理。方法对7例肝移植术后再次腹部手术患者的资料进行回顾性分析。结果5例择期手术患者围手术期平稳，痊愈出院。2例急诊手术患者中1例术后因并发上消化道应激穿孔、出血和切口感染自动出院。结论肝移植术后再次腹部择期手术的风险较急诊手术者低，与非肝移植行类似手术者相仿。