首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   8344篇
  免费   466篇
  国内免费   633篇
耳鼻咽喉   5篇
儿科学   31篇
妇产科学   11篇
基础医学   526篇
口腔科学   3篇
临床医学   808篇
内科学   85篇
皮肤病学   3篇
神经病学   345篇
特种医学   564篇
外科学   4048篇
综合类   1381篇
预防医学   206篇
眼科学   2篇
药学   489篇
  6篇
中国医学   823篇
肿瘤学   107篇
  2024年   46篇
  2023年   185篇
  2022年   252篇
  2021年   327篇
  2020年   308篇
  2019年   222篇
  2018年   253篇
  2017年   280篇
  2016年   299篇
  2015年   324篇
  2014年   748篇
  2013年   642篇
  2012年   675篇
  2011年   623篇
  2010年   603篇
  2009年   470篇
  2008年   381篇
  2007年   372篇
  2006年   360篇
  2005年   275篇
  2004年   275篇
  2003年   273篇
  2002年   196篇
  2001年   162篇
  2000年   111篇
  1999年   141篇
  1998年   85篇
  1997年   81篇
  1996年   76篇
  1995年   70篇
  1994年   58篇
  1993年   56篇
  1992年   38篇
  1991年   22篇
  1990年   12篇
  1989年   22篇
  1988年   15篇
  1987年   17篇
  1986年   20篇
  1985年   12篇
  1984年   8篇
  1983年   4篇
  1982年   10篇
  1981年   3篇
  1980年   5篇
  1979年   9篇
  1978年   3篇
  1977年   5篇
  1976年   3篇
  1971年   3篇
排序方式: 共有9443条查询结果,搜索用时 15 毫秒
1.
BACKGROUNDGuillain-Barré syndrome (GBS) is a rare disorder that typically presents with ascending weakness, pain, paraesthesias, and numbness, which mimic the findings in lumbar spinal stenosis. Here, we report a case of severe lumbar spinal stenosis combined with GBS.CASE SUMMARYA 70-year-old man with a history of lumbar spinal stenosis presented to our emergency department with severe lower back pain and lower extremity numbness. Magnetic resonance imaging confirmed the diagnosis of severe lumbar spinal stenosis. However, his symptoms did not improve postoperatively and he developed dysphagia and upper extremity numbness. An electromyogram was performed. Based on his symptoms, physical examination, and electromyogram, he was diagnosed with GBS. After 5 d of intravenous immunoglobulin (0.4 g/kg/d for 5 d) therapy, he gained 4/5 of strength in his upper and lower extremities and denied paraesthesias. He had regained 5/5 of strength in his extremities when he was discharged and had no symptoms during follow-up.CONCLUSIONGBS should be considered in the differential diagnosis of spinal disorder, even though magnetic resonance imaging shows severe lumbar spinal stenosis. This case highlights the importance of a careful diagnosis when a patient has a history of a disease and comes to the hospital with the same or similar symptoms.  相似文献   
2.
戴锋  俞鹏飞  刘锦涛  姜宏 《中国骨伤》2020,33(5):414-419
目的:探讨非手术治疗破裂型腰椎间盘突出症的近中期疗效及预后转归。方法:选取2011年2月至2014年2月接受非手术治疗的75例单节段破裂型腰椎间盘突出症患者进行前瞻性研究,男53例,女22例;年龄18~58(35.62±9.96岁);病程5 d~6个月,平均(46.45±40.66) d。突出节段:L_(3,4) 4例,L_(4,5) 29例,L_5S_1 42例。放射痛左侧46例,右侧29例。选取治疗前,治疗后3个月、6个月、1年、2年、5年6个时间点对患者JOA评分、直腿抬高角度(SLRT)、指地距统计分析。计算末次随访时(治疗后5年)JOA改善率,根据JOA评分评定疗效;分析治疗前、末次随访(治疗后5年)椎间盘突出物体积变化,计算突出物体积吸收率,观察突出物吸收情况;分析JOA改善率与突出物吸收率之间关系。结果:71例患者完成随访,非手术治疗后3个月、6个月、1年、2年、5年JOA评分、SLRT、指地距与治疗前比较,差异有统计学意义(P0.05)。治疗后5年与6个月、治疗后5年与2年、治疗后2年与6个月JOA评分比较,差异无统计学意义(P0.05),其余各时间点两两比较,差异均有统计学意义(P0.05);治疗后5年与6个月、治疗后5年与2年、治疗后2年与6个月SLRT、指地距比较,差异亦无统计学意义(P0.05),其余各时间点两两比较,差异均有统计学意义(P0.05)。末次随访JOA改善率为(62.69±2.47)%,按照JOA评分评定疗效,结果优26例,良26例,可14例,差5例,优良率73.24%;突出物体积由起始的(1 981.73±588.72) mm3减少至(1 011.82±395.47) mm3,总体吸收率(45.65±2.83)%,突出物发生明显吸收24例,部分吸收26例,未吸收19例,增大2例。JOA改善率与突出物吸收率作Spearman秩相关分析,发现两者呈中等以上正相关(r=0.679,P0.001)。结论:非手术治疗破裂型腰椎间盘突出症可取得良好疗效,明确了破裂型腰椎间盘突出症的病情特点及预后转归,同时部分患者发生"重吸收"现象。  相似文献   
3.
4.
5.

Background Context

The concept of dynamic stabilization (DS) of the lumbar spine for treatment of degenerative instability has been introduced almost two decades ago. Dynamic stabilization follows the principle of controlling movement in the coronal plane by providing load transfer of the spinal segment without fusion and, at the same time, reducing side effects such as adjacent segment disease (ASD). So far, only little is known about revision rates after DS due to ASD and screw loosening (SL).

Purpose

The present study aimed to evaluate the longitudinal revision rates following dynamic pedicle screw stabilization in the lumbar spine and to determine specific risk factors predictive for ASD, SL, and overall reoperation in a large cohort with considerable follow-up.

Design

We carried out a post hoc analysis of a prospectively collected database in a level I spine center.

Patients Example

The patient sample comprised 283 (151 female/132 male) consecutive patients suffering from painful degenerative lumbar segmental instability with or without spinal stenosis who underwent DS of the lumbar spine (Ulrich Cosmic, Ulrich Medical, Ulm, Germany) between January 2008 and December 2011.

Outcome Measures

Longitudinal reoperation rate and risk factors predictive for revision surgery were evaluated.

Methods

We analyzed the longitudinal reoperation rate due to ASD and SL and overall reoperation. Risk factors such as age, gender, body mass index, lumbar lordosis (LL), number of segments, and number of previous surgeries were taken into account. Regular and mixed model logistic regressions were performed to determine risk factors for revision surgery on a patient and on a screw level.

Results

The mean age was 65.7±10.2 years (range 31–88). One hundred thirty-two patients were stabilized in 1 segment, 134 in 2 segments, 15 in 3 segments, and 2 patients in 4 segments. Reoperation rate for ASD and SL after 1 year was 7.4 %, after 2 years was 15.0%, and after a mean follow-up of 51.4±15 months was 22.6%. Reasons for revision were SL in 19 cases (6.6%), ASD in 39 cases (13.7%), SL and ASD in 6 cases, hematoma in 2 cases (0.7%), cerebrospinal fluid fistulae in 3 cases (1.1%), infection in 6 cases (2.1%), and implant failure in 1 case (0.4%). The patients' age, the number of stabilized segments, and the number of previous surgeries and postoperative LL had a significant influence on the probability for revision surgery.

Conclusions

Reoperation rates after DS of the lumbar spine are comparable with rigid fixations. The younger the patient and the more segments are involved, the lower the LL and the more previous surgeries were found, the higher was the risk of revision. Risk of revision was almost twice as high in men compared with women. We therefore conclude that for clear clinical indication and careful evaluation of preoperative imaging data, DS using the Cosmic system seems to be a possible option. The presented data will help to further tailor indication and patient selection.  相似文献   
6.
7.
Ewing sarcoma (ES) is a rare primary neoplasm in the lumbar adult spine and may mimic a benign tumor. In this case, after a patient's three-month history of lower back pain and rapidly progressing leg numbness and weakness, magnetic resonance imaging (MRI) showed a mass in the third lumbar vertebra. At a two-month follow-up, imaging showed a fracture, compression and lesion enlargement. Decompression and fixation confirmed ES, and the patient began combined radiotherapy and chemotherapy. Two months postoperatively, residual ES was suspected on MRI. The patient underwent a second surgery, and histopathology confirmed necrosis. A six-month follow-up after the first surgery showed no tumor recurrence. This case supports the inclusion of ES in the differential diagnosis of pathologic spinal fracture. Early decompression and spinal fixation are critical for preserving neurologic and spinal functions in ES complicated by a compression fracture. Combined adjuvant radiotherapy and chemotherapy remain the standard therapeutic strategy.  相似文献   
8.
目的:分析针刀与针灸配合应用于腰椎间盘突出症患者中的临床治疗效果。方法:在我院针灸康复科2017年12月-2018年12月治疗的腰椎间盘突出症患者中选取64例,并严格按照系统随机分配原则分为对照组和观察组,各32例。其中对照组采用针灸进行治疗,观察组采用针刀与针灸配合治疗,观察对比两组患者治疗后临床效果和治疗前后运动功能评分(Fugl-Meyer)、腰椎日本骨科学会(Japanese Orthopaedic Association,JOA)评分、视觉模拟评分法(Visual Analogue Scale,VAS)评分以及临床症状改善情况。结果:两组患者治疗前Fugl-Meyer、VAS、JOA评分差异无统计学意义(P>0.05),治疗后对照组VAS评分高于观察组,Fugl-Meyer、JOA评分低于观察组,且对照组总有效率低于观察组,对照组腰骶疼痛评分和腿疼痛评分均低于观察组,直腿抬高度高于观察组,差异具有统计学意义(P<0.05)。结论:予以腰椎间盘突出症患者针刀与针灸配合治疗效果显著,效果优于单一使用针灸治疗,可有效缓解患者疼痛感,改善临床症状,值得推广。  相似文献   
9.
MED治疗腰椎间盘突出症时对神经根变异的探查   总被引:7,自引:1,他引:6  
目的:观察显微内窥镜下椎间盘切除术(microendoscopic discectomy,MED)治疗腰椎间盘突出症时神经根变异情况,防止出现术中神经根损伤。方法:回顾分析自1999年10月至2003年12月应用MED治疗的腰椎间盘突出症患者724例,其中男452例,女272例。对术中发现存在腰骶神经根变异患者的临床特点及术中所见进行统计分析。结果:724例腰椎间盘突出症患者有37例神经根变异,发生率为5.1%。与术前的临床表现吻合,全部神经根变异患者均在MED下完成手术,无一例出现神经根损伤。结论:仔细探查及分离突出髓核周围神经根发出情况.确定有无神经根变异是防止MED治疗腰椎间盘突出症时发生神经根损伤的重要环节之一。  相似文献   
10.
目的:探讨椎管扩大成形术治疗腰椎管狭窄的效果。方法:椎板减压后复位,用棘突或髂骨植于一侧开槽处扩大椎管,并进行椎板及关节突关节植骨,对54例随访病人的手术前后临床表现及X线和CT进行比较。结果:随访6—39个月,临床优良率为81.1%。随访X线片显示椎板明显后移,CT测量与术前对比显示椎管内径扩大明显。结论:椎管扩大成形术操作简单,效果满意,术后并发症少,是治疗腰椎管狭窄的又一选择。  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号