Indoor air pollution and pulmonary performance: investigating errors in exposure assessment

We use pulmonary function measurements on pre-adolescent children and indoor air pollution measurements in the homes of these children to illustrate estimation techniques for linear regression models containing independent variables measured with error. In our data set, replicate measures of indoor air pollutant concentrations provide one method of estimating measurement error variances. Surrogate information in the form of cigarettes smoked is also available for the pollutant of interest. Several estimation procedures are presented, and we combine two estimators, one based on surrogate information and one based on replication information, using generalized least squares.     

The pitfalls of the dexamethasone suppression test: A biological marker of endogenous depression?

In the past few years there have been numerous publications which have stressed the value of the dexamethasone suppression test (DST) as a diagnostic marker of endogenous depression. Our own studies in 333 psychiatric inpatients and 121 healthy subjects did not reveal a differential diagnostic use for the DST. This result is in good agreement with other results in the literature. Our data demonstrate that intervening variables such as severity of illness, weight loss, sleep disturbances, situational stress, drug and alcohol withdrawal, and the pharmacokinetics of dexamethasone have an important influence on DST results, regardless of the diagnostic classification.     

利用外感病因物元模型系统分析外感病因因素的相关性

目的：将外感病因的研究与可拓学结合起来,利用外感病因物元模型系统分析外感病因因素的相关性。方法：初步设定中医外感病因模型,并进行大量临床病例调查,对搜集到的外感病信息进行统计分析和数据挖掘,得出每个影响因素的相关度。结果：共搜集有效问卷402份,其中患感冒的有156份,占全部有效问卷的38.8%。通过统计学频数分析,得出外感病相应的产生式规则和关联函数为：F感冒=（f风,雨,湿度,…,吸烟,饮酒）。结论：此项研究有利于对外感病因进行量化和层次化研究,对于外感病的预警及防治具有积极的意义。     

将可拓学应用于外感病病因研究的探讨

中医外感病是多因素作用的结果,用传统方法很难在病因研究上取得突破性进展。我们引入了专门用于解决矛盾问题的可拓学来分析致病因素与外感病以及各因素之间的相互关系。本文简单介绍了可拓学,就可拓学对外感病病因研究的指导作用进行了分析,还展望了医院信息系统。     

杏苏散治疗外感咳嗽(凉澡伤肺证)50例

目的:观察杏苏散治疗外感咳嗽的临床效果。方法:100例外感咳嗽的患者被随机分为治疗组和对照组,每组各50例,治疗组采用杏苏散进行治疗,对照组用咳必清联合酚麻美敏治疗。结果:治疗组痊愈46例,显效2例,好转2例,无效0例,有效率100%。对照组痊愈41例,显效2例,好转6例,无效1例,有效率98%。结论:杏苏散治疗外感咳嗽有良好的效果。     

外源性神经生长因子治疗急性脑梗死疗效观察

目的 观察恩经复治疗急性脑梗死的疗效.方法 将215例急性脑梗死患者随机分为治疗组和对照组,两组基础用药相同.其中治疗组115例,除基础用药外,加外源性鼠神经生长因子（恩经复）每日1次肌注,每次9000 IU.10天为一疗程,共用两个疗程;对照组100例,仅用基础用药.使用美国国立卫生研究所脑卒中评分（NIHSS）评价神经功能恢复情况.结果 （1）治疗30天后,恩经复治疗组的NIHSS评分较对照组有明显改善（P＜0.05）;治疗组有效率（80.87%）高于对照组（67%）,差异有统计学意义（P＜0.05）.（2）两组均未发生明显不良反应.结论 恩经复治疗急性脑梗死安全有效.     

Spatial deployment of attention within and across hemifields in an auditory task

Research on visual attention has demonstrated that covert attention can be focused on particular locations within one hemifield, but that a specific "meridian" cost may also be found for shifting attention between hemifields. These issues have received less consideration for audition, even though reliable behavioral measures for the effects of spatial attention on hearing are now available. We examined the spatial distribution of covert attention in an auditory task following spatially non-predictive peripheral auditory cues (which should induce exogenous attention shifts), or following symbolic central cues that predicted the likely location for the auditory target (to induce endogenous attention shifts). In both cases, we found that attention can be focused not only on one hemifield versus another, but also within one hemifield in an auditory task. However, there was no unequivocal evidence for a meridian effect in audition. Electronic Publication     

磷酸肌酸含血心停搏液对联合瓣膜置换术心肌保护作用研究

目的观察含血圣.托马斯(STH2)液加入外源性磷酸肌酸(CP)后对重症瓣膜病患者联合瓣膜置换术心肌保护作用。方法40例同期行二尖瓣、主动脉瓣置换术患者随机分为两组,CP治疗组在含血STH2心灌注液中加入CP,对照组用等量含血STH2液,分别切开主动脉根部经冠状动脉窦直接灌注,观察心脏复搏情况、术后机械通气及监护室停留情况。两组分别于麻醉诱导前、诱导后、主动脉阻断开放后6h、16h,采集患者中心静脉血,测血细胞比积(HCT)、磷酸肌酸激酶同工酶(CK-MB)、心肌钙蛋白I(cTn-I)。结果CP治疗组心脏自动复搏率较对照组高,术后多巴胺用量较对照组少,两组术后CK-MB、cTn-I较术前高,CP治疗组较对照组高。结论CP加入心停搏液中能显著提高心肌保护作用。