坐浴散熏蒸坐浴治疗混合痔术后疼痛、水肿临床研究

目的:观察中药坐浴散熏蒸坐浴治疗混合痔术后疼痛、水肿的临床疗效。方法:选取165例混合痔术后患者,按随机数字表法分为治疗组83例和对照组82例。2组手术方式均为外剥内扎术或痔上黏膜环切术(PPH)加外剥内扎术。术后治疗组给予坐浴散熏蒸坐浴治疗,对照组给予1∶5000高锰酸钾溶液熏蒸坐浴治疗。比较2组术后不同时间段的视觉模拟评分法(VAS)评分、肛缘水肿评分,比较2组临床疗效及术后切口愈合时间。结果:2组术后第3天、第7天,治疗组VAS评分及肛缘水肿评分均低于同期对照组,差异有统计学意义(P<0.05)。治疗组总有效率为96.38%,对照组总有效率为86.58%,2组比较,差异有统计学意义(P<0.05)。治疗组术后切口平均愈合时间短于对照组,差异有统计学意义(P<0.05)。结论:坐浴散熏蒸坐浴用于混合痔术后患者,可有效减轻其疼痛和肛缘水肿情况,促进手术切口愈合,疗效明显优于对照组。     

实验性大鼠脑出血后神经肽Y的变化及抑肽酶的干预作用

目的观察大鼠脑出血后神经肽Y的表达与脑出血后脑含水量变化的关系,以及抑肽酶对其的影响。方法通过采用未抗凝新鲜自体股动脉血注入大鼠尾状核建立脑出血动物模型,用放射免疫法测定脑出血后6h和1、3、5及7天神经肽Y的变化,用干重—湿重法测定脑出血后脑含水量的变化,并与神经肽Y进行相关分析。结果与对照组比较,血肿周围组织中神经肽Y水平在脑出血后1天和3天时显著升高(P<0.05),6天时降至正常。血肿周围组织含水量在脑出血后6h轻度增加,1天时显著增加(P<0.01),3天时达高峰(P<0.01),以后逐渐下降,7天时基本恢复正常水平;抑肽酶组脑含水量及神经肽Y含量均明显减少。结论神经肽Y可能参与实验性脑出血后血肿周围水肿的形成;抑肽酶对二者有抑制作用,抑肽酶可能有助于减轻脑出血后脑水肿的形成。     

Relief Effect of Bevacizumab on Severe Edema Induced by Re-irradiation in Brain Tumor Patients

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EGLN1基因多态性位点rs479200、rs2790870与高原肺水肿的关系

目的探讨EGLN1基因多态性位点rs479200、rs2790870与高原肺水肿(High-altitude pulmonary edema,HAPE)的关系。方法采用病例对照研究,选取HAPE患者128例(HAPE组)及性别、年龄等相匹配的127例为对照组。采用PCR-测序法检测EGLN1基因的rs479200、rs2790870单核苷酸位点的多态性。结果HAPE组和对照组间rs479200和rs2790870位点的C等位基因频率分别为42.2%、42.5%和52.3%、58.3%,T等位基因频率分别为57.8%、57.5%和47.7%、41.7%,两组C、T等位基因频率分布差异无统计学意义(P>0.05);HAPE组和对照组间rs479200位点TT、TC和CC基因型频率分别为35.2%、45.3%、19.5%和36.2%、42.5%、21.3%,两组比较差异无统计学意义(P>0.05)。HAPE组和对照组间rs2790870位点TT、TC和CC基因型频率分别为24.2%、46.9%、28.9%和21.3%、40.9%、37.8%,两组比较差异无统计学意义(P>0.05)。结论 EGLN1基因多态性位点rs479200、rs2790870的基因型及等位基因频率无差异,提示在本研究中与HAPE的发病无关。     

Bone Marrow Edema Syndrome of the Medial Femoral Condyle Treated With Extracorporeal Shock Wave Therapy: A Clinical and MRI Retrospective Comparative Study

Objective

To determine the validity of extracorporeal shock wave therapy (ESWT) in the treatment of bone marrow edema (BME) of the medial condyle of the knee.

Prognostic values of gray matter to white matter ratios on early brain computed tomography in adult comatose patients after out-of-hospital cardiac arrest of cardiac etiology

Aim of the studyPrevious studies found that the gray matter to white matter ratio (GWR) on brain computed tomography (CT) could be used to predict poor outcomes in cardiac arrest survivors. However, these studies have included cardiac arrests of both cardiac and non-cardiac etiologies. We sought to evaluate if the GWR on brain CT can help to predict poor outcomes after out-of-hospital cardiac arrest (OHCA) of cardiac etiology.MethodsUsing a multicenter retrospective registry of adult cardiac arrest survivors treated with therapeutic hypothermia, we identified survivors of OHCA of cardiac etiology who underwent brain CT within 24 h after successful resuscitation. Gray and white matter attenuations were measured, and the GWRs were calculated as in previous studies. The prognostic values of the GWRs were analyzed, and a logistic regression analysis was performed to determine the contribution of the GWR in predicting poor outcomes (Cerebral Performance Category 3–5).Resultsof 283 included patients, 140 had good outcomes and 143 had poor outcomes. Although the GWRs could predict poor outcomes with statistical significance, the sensitivities were remarkably low (3.5% to 5.6%) at cutoff values with 100% specificity. No significant difference in predictive performance was found between the primary predictive model, containing independent poor outcome predictors, and the primary predictive model combined with the GWR.ConclusionIn a cohort of comatose adults after OHCA of cardiac etiology, the GWR demonstrated poor predictive performance and was not helpful in predicting poor outcomes.     

Respuesta inflamatoria de la exacerbación asmática de instauración rápida

The association between onset of asthma exacerbation and the inflammatory response has not been sufficiently studied.     

《内经》水肿论治探究

《黄帝内经》是中医经典著作之一,为中医学理论发展的基石。为探究水肿病论治规律,求本溯源,对《内经》中有关水肿的论述加以整理理、研究,发现后世诸多水肿治则、治法皆发端于《内经》,至今对现代临床仍具现实指导意义。《内经》已明确提出水肿成因有外感、内伤之分;水肿病机主要是阳气阻遏、气化失司、血脉瘀阻、聚水为肿;并提出了切实可行的治则、治法,既包括药物、针刺治疗,又提出了饮食的重要性,开拓了水肿食疗之先河。     

姚荷生活用防已茯苓汤的案例分析

本文收集了名医姚荷生先生运用防已茯苓汤加减辨冶的亲笔病案77例,通过数据整理、统计分析,客观探讨其运用本方的辨证指征与加减方法,挖掘其活用本方的学术思想与独到经验,推广名方防已茯苓汤的使用范围,启迪后学对经方、经典的活学活用。