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101.
K. Terayama Syuji Toda Nobuhisa Yonemitsu Norimasa Koike Hajime Sugihara 《Virchows Archiv : an international journal of pathology》1997,431(4):291-295
We describe a rare case of papillary carcinoma with extensive proliferation of stromal cells. The stromal cells were immunocytochemically
positive for vimentin, α-smooth muscle actin and desmin, but negative for cytokeratin, epithelial membrane antigen, S-100,
thyroglobulin and CD34. These results and the ultrastructure of the stromal cells, which exhibited the characteristics of
both fibroblasts and smooth muscle cells, indicated an origin from myofibroblasts. We conclude that myofibroblastic proliferation
may contribute to the stromal response in the slow growth of the papillary carcinoma.
Received: 29 August 1996 / 26 May 1997 相似文献
102.
Aims : Adenocarcinomas account for about 60% of metastatic cancers of unknown primary (CUP) site. In such a clinical CUP situation, histopathologists are challenged to differentiate renal cell carcinomas (RCC) from other adenocarcinomas with similar immunophenotypes, especially chemotherapeutically treatable mammary and ovarian carcinomas. Methods and results : Recently, we produced a monoclonal antibody (mAb), designated 138H11, against human gamma-glutamyltransferase (γGT), which stained over 98% primary clear cell and chromophilic RCC on frozen sections. The 138H11 epitope could not be stained using conventional techniques in most paraffin-embedded sections of the same origin, due to destruction by formalin fixation below the detection level. Here, we demonstrate that mAb 138H11 can specifically stain γGT in paraffin-embedded primary and metastatic RCC after enhancement with an ultrasensitive immunohistochemical method. We analysed a selected subgroup of adenocarcinomas with immunophenotypes which would not allow a differentiation from RCC in a CUP situation. We found a predominantly membranous expression of the 138H11 target antigen in 26/51 primary RCC and 15/34 metastatic RCC. In contrast, all 43/43 primary ovarian and bronchial carcinomas as well as 54/54 metastases of ovarian, mammary, bronchial and gastric carcinomas were negative for mAb 138H11. Conclusions : The data suggest that mAb 138H11 is useful for the immunohistochemical differentiation of RCC from other metastatic adenocarcinomas if the primary site of the tumour is not known. 相似文献
103.
A. G. Douglas-Jones H. Navabi J. M. Morgan B. Jasani 《Virchows Archiv : an international journal of pathology》1997,430(5):373-379
Immunocytochemically detectable MT and p53 have been found more commonly in comedo DCIS of the breast with high-grade cytology.
The aim of this study is to confirm these findings and to investigate the relationship between MT and p53 in a single large
series of cases of DCIS of the breast. To this end, 127 cases of DCIS were classified histologically according to architecture,
cytonuclear differentiation (grade), presence and extent of intraduct necrosis, and using the Van Nuys system. Sections were
immunostained for p53 and MT (E9) using established techniques, and the extent and intensity of staining were assessed semi-quantitively.
The results confirmed that there was generally more MT and p53 positivity in poorly differentiated (grade 3) DCIS with extensive
necrosis and that MT expression was greater in grade 2 lesions than p53 expression. However, overall there was no statistically
significant correlation between p53 and MT staining. The results indicate that MT and p53 overexpression may arise from independent
mechanisms in early breast neoplasia.
Received: 3 July 1996 / Accepted: 5 November 1996 相似文献
104.
采用手术切除联合术后B超引导肝内门静脉区域化疗(简称PHPC)治疗胃肠道癌异时肝转移24例。随访4~54个月,结果:术后经3个疗程的PHPC,8例已存活肥18~48个月;13例分别经过2~11次的PHPC,已存活5~39p个月;另3例死亡。作者认为,对继发性肝癌采用手术切除配合术后B超引导的PHPC是一种延长患者生存期的有效联合治疗方案。 相似文献
105.
薄层动态CT对胰腺癌的早期诊断 总被引:1,自引:0,他引:1
笔者采用薄层动态CT扫描,诊断直径≤3cm的胰腺癌12例,其直接征象为胰头轻度不规则增大或有小的局部隆起、钩突圆隆变形、胰腺实质的分叶形态消失;间接征象为胰管、胆管的梗阻性扩张。认为薄层动态CT扫描是早期胰腺癌诊断的有效方法。 相似文献
106.
Takashi Ito Kazuo Shimamura Kiyoshi Shoji Akira Akatsuka Yasuyoshi Kiryu Norikazu Tamaoki Yoshiyuki Osamura 《Virchows Archiv : an international journal of pathology》1993,422(6):487-490
A rare case of urinary bladder carcinoma with granulocyte colony stimulating factor (G-CSF) production was reported. In an 83-year-old female, marked neutrophilia in the peripheral blood decreased from 132,500/mm3 to 3,300/mm3 after tumour resection. The tumour was a transitional cell carcinoma. The serum G-CSF level reduced from 238 pg/ml pre-operatively to normal (60 pg/ml) after the operation. Immunohistochemical investigation of the resected tumour with monoclonal antibody specific for G-CSF revealed positive staining in the carcinoma cells, confirming G-CSF secretion. 相似文献
107.
Anu Kilpi Alison M. Rich Yrjö T. Konttinen Peter C. Reade 《European journal of oral sciences》1996,104(3):278-284
Oral mucosal lichen planus (OMLP) is a well recognized mucosal disease with unknown etiology. Considerable controversy exists as to whether OMLP is intrinsically premalignant, or if the disorder facilitates the development of oral mucosal squamous cell carcinoma (OMSCC) by external factors. The aim of the present study was to investigate the expression of c-erbB-2 protein in the keratinocytes of initial biopsies of oral mucosal disorders diagnosed as OMLP with no evidence of epithelial dysplasia. and to compare the results with the expression of c-erbB-2 protein in subsequent biopsies obtained from the same patients. These results were compared with the findings from control groups (patients with dysplasia with no evidence of OMLP, patients with OMSCC with no evidence of OMLP and normal oral mucosa). The expression of the c-erbB-2 protein was evaluated by immunohistochemical staining of the gene product with the avidin-biotin-complex method using paraffin-embedded tissue sections. Five of the initial biopsies from patients with OMLP expressed the c-erhB-2 protein and one did not. None of the OMLP cases that subsequently showed evidence of dysplasia expressed the c-erhB-2 protein, and of the three OMSCC specimens from the patients with OMLP. two were negative and one expressed c-erbB-2 protein. The specimens from the control groups all expressed the c-erhB-2 protein. The results indicated the probability of the absence of c-erbB-2 staining being an indication of a potential for neoplastic transformation in OMLP with dysplastic changes. 相似文献
108.
采用计算机图象纹理分析和相关点阵检测技术,对人食管正常粘膜、不典型增生上皮及原位癌的不同纹理特征进行了观察。观察样品为常规病理切片,用计算机图象分析系统检测了组织的纹理特征。对受检图象建立了三种灰色分层关系矩阵,同时计算了8种纹理测度。结果显示,在重度不典型增生上皮和原位癌之间,其纹理测度和相关点阵检测数据均有显著性差异(P<0.05)。全部测量数据经计算机多元逐步判别分析,其正判率达90%以上。本研究结果表明,计算机纹理分析方法可正确地判别食管癌前病变和原位癌的组织结构异型性。提示本技术在食管癌的早期诊断方面具有肯定的实用性价值。 相似文献
109.
目的:探讨人卵巢癌标本中,肿瘤转移抑制基因nm23-H1编码蛋白NDPK-A表达的临床意义及其与预后的关系。方法:应用免疫组织化学抗生蛋白链菌素-过氧化酶结合(S-P)法,检测58例人卵巢癌标本中nm23-H1蛋白水平。结果:nm23-H1蛋白的表达与患者手术时是否有淋巴结及大网膜转移相关(P〈0.05),但原发灶与转移灶间的阳性表达率相差不显著;与患者术后生存时间密切相关(P〈0.01),术后生 相似文献
110.
Robert C. Flanigan Joseph H. Saiers Michael Wolf Eric H. Kraut Anthony Y. Smith Brent Blumenstein E. David Crawford 《Investigational new drugs》1994,12(2):147-149
Summary The Southwest Oncology Group (SWOG) studied the response rate and toxicity of merbarone (1,000 mg/m2 IV continuous infusion days 1–5, q 21 days) in patients with advanced metastatic renal cell carcinoma. Among 36 eligible patients, there was one partial response for a response rate of 3% (95% C.I. 0.1–15%). There were no mixed responses. There were no treatment related deaths or adverse drug reactions. Significant anemia, diarrhea, and hypercalcemia were observed. Mild to moderate degrees of malaise/fatigue/lethargy, dizziness/vertigo, hyperglycemia, creatinine increase, nausea, vomiting, weight loss, pedal edema, dyspnea, and granulocytopenia were noted. Merbarone does not have significant activity as a single agent in advanced renal cell carcinoma. 相似文献