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981.
982.
A 49-year-old white female patient was referred to the ENT Department, Zentralkrankenhaus, Bremen, because of conductive hearing
loss. Widespread tumor formation was found in the left temporal bone and was identified by biopsy to be an osteoclastoma.
The tumor was extirpated surgically and reconstruction was performed. Periodic clinical follow-ups during a 36-month period
after surgery have included control computed tomographic scans and have shown no evidence for recurrent disease. The specific
pathology of the osteoclastoma is presented and different ways for treatment are discussed. 相似文献
983.
P. Pautier C. Lhommé S. Culine P. Duvillard G. Michel J.M. Bidart A. Gerbaulet & J.P. Droz 《International journal of gynecological cancer》1997,7(1):58-65
This study describes 45 cases of adult granulosa-cell tumors seen in our institution between 1976 and 1993. The median age was 46.5 years (12–77) and 18 women were postmenopausal. Vaginal bleeding was present in one-third of cases; other complaints were abdominal pain (28%) and the presence of a pelvic mass (47%). The tumor size was variable (<3 cm to 30 cm, median 11.5 cm). FIGO stages were: stage I: 30 (73%) (19 Ia, seven Ic, four I unknown); stage II: seven (17%) (two IIa, five IIC); stage III: three (7%) (one IIIb, two IIIc). Two adenocarcinomas and 13 cases of hyperplasia were found in 25 endometrial samples available. The initial therapy for all the cases was surgery, consisting in 34 patients of hysterectomy, bilateral salpingo-oophorectomy, ± tumor resection. Sixteen patients received adjuvant therapy as well: chemotherapy (CT) alone for 12, radiotherapy (RT) alone for two, and CT + RT for two patients. Among the 39 patients who achieved a complete response after initial therapy, 15 patients have relapsed (pelvic recurrences) (38.5%) including six stage Ia (three received only conservative surgery). All the recurrent tumors were resected and 14/15 had CT (13/14 with cisplatin). The overall survival rate was 77.2% at 5 years, 66.5% at 10 years, and 41.2% at 20 years. A statistically significant difference was found between the survival of patients with stage Ia disease (75% at 10 and 15 years) and that of other patients (60% at 10 years, and <50% at 15 years). Serum estradiol and serum inhibin were measured in some patients and the results are described. 相似文献
984.
N. P. KOPER L. F. A. G. MASSUGER C. M. G. THOMAS L. A. L. M. KIEMENEY C. P. T. SCHIJF L. V. A. M. BEEX & A. L. M. VERBEEK 《International journal of gynecological cancer》1997,7(2):127-133
Serum CA125 concentrations measured before and during chemotherapy may provide additional information for prognostic assessment of patients with epithelial ovarian cancer (EOC), and enable discrimination between patients who are likely to benefit from further therapy and those who will not. Medical records of 40 patients with advanced EOC, treated at the Department of Obstetrics and Gynecology of the University Hospital Nijmegen between July 1984 and April 1993, were examined. All patients had primary cytoreductive surgery followed by platinum-based chemotherapy. Serum samples were obtained before surgery and during chemotherapy. Follow-up information and patient and tumor characteristics were abstracted from medical records until December 1, 1994. By using multivariate Cox proportional hazards models for disease-free and overall survival it was evaluated whether outcome prediction was improved by inclusion of serum CA125 quantitations.
Only FIGO stage and extent of residual tumor were significant independent prognostic factors before the start of chemotherapy. When such regression models were constructed after subsequent courses of chemotherapy, serum CA125 measurements conducted after each of the first three chemotherapy courses improved the prediction of disease-free survival. Prediction of overall survival was improved by inclusion of serum CA125 measurements after courses 1–6. Inclusion of serum CA125 measurements during chemotherapy improved prognostic assessment of patients with advanced EOC. 相似文献
Only FIGO stage and extent of residual tumor were significant independent prognostic factors before the start of chemotherapy. When such regression models were constructed after subsequent courses of chemotherapy, serum CA125 measurements conducted after each of the first three chemotherapy courses improved the prediction of disease-free survival. Prediction of overall survival was improved by inclusion of serum CA125 measurements after courses 1–6. Inclusion of serum CA125 measurements during chemotherapy improved prognostic assessment of patients with advanced EOC. 相似文献
985.
Eight cases of glomus tumors hospitalized in our department from 1982 through 1995 were reviewed. It comprised of five glomus tympanic tumors and three glomus jugular tumors. Discussion was centered on it’s contemporary diagnosis, classification and surgical treatment with introduction of a modified combined intra-and extracranial surgical approach to resect the extensive glomus tumors. 相似文献
986.
本文对骨巨细胞瘤(GCT)的传统组织学分级与其生物学行为不甚相符的原因进行了研究。采用51例GCT为研究对象,以13例骨囊肿(良性)和15例骨肉瘤(恶性)为对照组,采用图像分析仪(IAT)对细胞核(GCT取基质细胞核),进行了形态计量研究(8项参量),DNA含量,DNA倍体类型研究,及术后复发病例的DNA倍性与其传统分级的比较研究。结果经统计学处理发现GCTⅠ级和Ⅱ级之间无显著差别,且它们的生物学属性在潜在恶性和低度恶性范畴。研究还揭示GCT的DNA≥5c细胞数超过7%者系术后复发、转移的高危病例。 相似文献
987.
Kazuhiko Ogawa Takafumi Toita Yasumasa Kakinohana Keiichiro Yamaguchi Koichi Miyagi Toshihiko Kinjyo Katsumi Yamashiro Satoshi Sawada 《International journal of clinical oncology / Japan Society of Clinical Oncology》1997,2(2):67-72
Background This retrospective study analyzed the outcome in patients with intracranial germ-cell tumors to determine whether tumor response
during radiation therapy can predict achievement of primary local control with radiation therapy alone.
Methods Between 1983 and 1993, 22 patients with untreated primary intracranial germ cell tumors received a total whole brain radiation
dose of between 18 Gy and 45 Gy (mean 31.3 Gy) with or without a localized field of 10 to 36.4 Gy (mean, 22.4 Gy), or local
irradiation only (1 patient). In 10 patients with pineal tumor only, who were treated first with radiation therapy, tumor
response to radiation therapy was evaluated using computed tomography (CT) (at baseline, and approximately 20 Gy and 50 Gy).
Areas of calcification in the tumor were subtracted from total tumor volume. Follow-up time ranged from 2 to 12 years.
Results Five-year actuarial survival rates for patients with germinoma were 71%, 100% for patients with a teratoma component, and
100% for patients without histologic verification. Patients with germinomas or tumors suspected of being germinomas who were
given more than 50 Gy had no local relapse. There was no correlation between primary local control by radiation therapy alone
and initial tumor volume. The rate of tumor volume response to irradiation assesed by CT was significantly different in those
patients who relapsed compared to those who did not relapse
Conclusion Tumor response during radiation therapy using CT was considered to be predictive of primary local control with radiation therapy
alone. 相似文献
988.
Tsukasa Ohnishi Kiyoshi Mori Sei Ohta Kohei Yokoi Naoto Miyazawa Keigo Tominaga Mitsuru Adachi 《International journal of clinical oncology / Japan Society of Clinical Oncology》1997,2(4):235-237
Tumor lysis syndrome is a rare complication of nonhematologic malignancies that results from massive necrosis of neoplastic
cells after chemotherapy. This syndrome consists of life-threatening metabolic derangements, including severe hyperphosphatemia,
hyperkalemia, hyperuricemia, and hypocalcemia, and may result in renal failure and death if not recognized early and treated
appropriately. We report a case of tumor lysis syndrome after induction chemotherapy in a patient with widely metastatic smallcell
lung cancer. This case emphasizes the importance of awareness and early treatment of this syndrome. 相似文献
989.
恶性胸腹水自体蛋白的制备及回输 总被引:8,自引:1,他引:8
恶性肿瘤晚期患者常并发胸腹水,胸腹水里含有大量可溶性蛋白,蛋白浓度约为40mg/ml,其中白蛋白占50%以上,球蛋白占20%左右。本实验室比较了4种不同的分离纯化胸腹水蛋白的方法,其中离心滤过的方法能彻底除去细胞成分,特别是肿瘤细胞,而且蛋白回收率高,操作简单,不参入外源物质,我们采用该方法将恶性胸腹水中的蛋白回收,并回输给患者,临床应用27例次,取得了较好的临床效果。 相似文献
990.
目的:观察中药抗癌宝口服液治疗中晚期恶性肿瘤临床效果。方法:103例患者随机分为抗癌宝观察组与化疗对照组,对两组疗效作比较。结果:观察组患者免疫功能,近期有效率(CR+PR),生存质量,1、2、3年生存期及中位生存时间,癌胚抗原下降水平,明显高于对照组,且有显著性差异。结论:抗癌宝具有抑制肿瘤生长,延长生存时间,提高生存质量之效。 相似文献