国产硝酸咪康唑霜治疗癣病270例

本文报道用国产硝酸咪康唑霜治疗270例癣病,其中体、股癣18例,0.5 mo(月)内痊愈17例;足癣252例,2kw(周)有效率为86.3％,霉菌培养阴转率为83.3％,56例连续用药4 wk后有效率达94％,霉菌培养阴转率为92％,两者与对照组比较均有非常显著性差异。咪康唑是目前治疗皮肤癣菌病较为满意的药物之—,值得推广应用。     

复方联苯苄唑液治疗角化型手足癣的双盲对照研究

目的观察复方联苯苄唑治疗角化型手足癣的临床疗效。方法采用随机双盲对照法观察复方联苯苄唑液(试验组)与联苯苄唑液(对照组)外用治疗角化型手足癣的临床疗效。结果试验组瘙痒、红斑、丘疹和角化的平均消失时间比对照组短,消失率亦明显高于对照组,统计学处理均有显著性差异(P<0.05)。真菌学评价:试验组治疗4周后真菌转阴率为93.90%,对照组转阴率为74.39%,明显低于试验组(P<0.05)。停药后2周再次真菌检查试验组转阴率升至96.31%,对照组则降为70.67%。试验组痊愈率为75.61%,有效率为100%,对照组分别为58.54%和81.71%。试验组和对照组均未见明显不良反应。结论复方联苯苄唑液治疗角化型手足癣临床疗效高,无明显副作用。     

Anderson-Fabry disease-family linkage studies using two polymorphic X-linked DNA probes

Anderson-Fabry disease is an X-linked lysosomal storage disorder due to -galctosidase A deficiency. In affected males there is a high mortality in early adult life due to renal failure and cardiovascular complications. We describe our preliminary results from genetic linkage studies in five families using two polymorphic DNA probes, DXS17 and DXYS1, mapping to an area on the long arm of the X chromosome between Xq13–22. DXS17 identified a Taql polymorphism closely linked to the disease locus in three families (lod_max Z=4.23. at a recombination fraction =0.0). Restriction fragment length polymorphisms detected by DXYS1 were not linked.     

A novel association between angiokeratoma corporis diffusum and acid sphingomyelinase deficiency

Angiokeratoma corporis diffusum refers to symmetrical clusters of minute red papules in a “bathing trunk” distribution and is considered the cutaneous hallmark of Fabry disease. Acid sphingomyelinase deficiency is an autosomal recessive sphingolipidosis, which presents with massive hepatosplenomegaly, pulmonary infiltrates, and skeletal abnormalities. We present the unusual case of a 12‐year‐old girl with acid sphingomyelinase deficiency who developed characteristic lesions of angiokeratoma corporis diffusum.     

Tinea incognito due to microsporum gypseum

A 41-year-old woman presented with a pruritic rash on the face that was of 3 months duration. During that time, it had been successively misdiagnosed as psoriasis vulgaris, systemic lupus erythematosus, facial dermatitis at other hospitals, and had been treated with agents that included acitretin and prednisone. Finally, fungi were found in the lesions by optical microscopy, and the fungal culture was positive for Microsporum gypseum, and was diagnosed as a Microsporum gypseum infection. The lesions eventually cleared completely after 8 weeks of antifungal treatment.