全文获取类型
收费全文 | 18645篇 |
免费 | 1702篇 |
国内免费 | 374篇 |
专业分类
耳鼻咽喉 | 140篇 |
儿科学 | 396篇 |
妇产科学 | 96篇 |
基础医学 | 2709篇 |
口腔科学 | 151篇 |
临床医学 | 1372篇 |
内科学 | 881篇 |
皮肤病学 | 5618篇 |
神经病学 | 555篇 |
特种医学 | 504篇 |
外国民族医学 | 3篇 |
外科学 | 2523篇 |
综合类 | 1782篇 |
预防医学 | 692篇 |
眼科学 | 115篇 |
药学 | 1711篇 |
13篇 | |
中国医学 | 558篇 |
肿瘤学 | 902篇 |
出版年
2024年 | 84篇 |
2023年 | 448篇 |
2022年 | 482篇 |
2021年 | 640篇 |
2020年 | 824篇 |
2019年 | 716篇 |
2018年 | 646篇 |
2017年 | 605篇 |
2016年 | 664篇 |
2015年 | 612篇 |
2014年 | 944篇 |
2013年 | 1435篇 |
2012年 | 863篇 |
2011年 | 995篇 |
2010年 | 820篇 |
2009年 | 794篇 |
2008年 | 783篇 |
2007年 | 878篇 |
2006年 | 770篇 |
2005年 | 692篇 |
2004年 | 608篇 |
2003年 | 593篇 |
2002年 | 526篇 |
2001年 | 476篇 |
2000年 | 306篇 |
1999年 | 365篇 |
1998年 | 313篇 |
1997年 | 325篇 |
1996年 | 293篇 |
1995年 | 241篇 |
1994年 | 191篇 |
1993年 | 165篇 |
1992年 | 180篇 |
1991年 | 144篇 |
1990年 | 138篇 |
1989年 | 133篇 |
1988年 | 122篇 |
1987年 | 123篇 |
1986年 | 111篇 |
1985年 | 101篇 |
1984年 | 91篇 |
1983年 | 64篇 |
1982年 | 73篇 |
1981年 | 68篇 |
1980年 | 60篇 |
1979年 | 58篇 |
1978年 | 23篇 |
1977年 | 27篇 |
1976年 | 33篇 |
1975年 | 22篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
971.
Ultraviolet A photosensitivity profile of dexchlorpheniramine maleate and promethazine‐based creams: Anti‐inflammatory,antihistaminic, and skin barrier protection properties 下载免费PDF全文
972.
Assessment of cubosomal alpha lipoic acid gel efficacy for the aging face: a single‐blinded,placebo‐controlled,right‐left comparative clinical study 下载免费PDF全文
973.
974.
Keratoacanthoma formation after skin grafting: A brief report and pathophysiological hypothesis 下载免费PDF全文
Senhong Lee Ian Coutts Andrew Ryan Anastasios Stavrakoglou 《The Australasian journal of dermatology》2017,58(3):e117-e119
Keratoacanthoma formation after skin grafting is rare. We report the third case in the literature of multiple keratoacanthomas developed at both split‐thickness skin graft donor and recipient sites. We provide possible explanations for this poorly understood phenomenon and highlight its implications on treatment options. 相似文献
975.
976.
Here, we report a model for studying wound repair based on skin regenerated from human tissue culture‐expanded cells. The reconstituted skin (hRSK) responds to injury similar to that of intact human skin, and its constituent cells contribute to the healing process. As we have demonstrated that hRSK composed of GFP‐labelled cells also heals “normally,” we believe this model will be useful in analysing the wound repair process using genetically modified human cells. 相似文献
977.
Expression of claudin‐11 by tumor cells in cutaneous squamous cell carcinoma is dependent on the activity of p38δ 下载免费PDF全文
Liisa Nissinen Elina Siljamäki Pilvi Riihilä Minna Piipponen Mehdi Farshchian Atte Kivisaari Markku Kallajoki Laura Raiko Juha Peltonen Sirkku Peltonen Veli‐Matti Kähäri 《Experimental dermatology》2017,26(9):771-777
The incidence of cutaneous squamous cell carcinoma (cSCC) is rapidly increasing, and the prognosis of patients with metastatic disease is poor. There is an emerging need to identify molecular markers for predicting aggressive behaviour of cSCC. Here, we have examined the role of tight junction (TJ) components in the progression of cSCC. The expression pattern of mRNAs for TJ components was determined with RNA sequencing and oligonucleotide array‐based expression analysis from cSCC cell lines (n=8) and normal human epidermal keratinocytes (NHEK, n=5). The expression of CLDN11 was specifically elevated in primary cSCC cell lines (n=5), but low or absent in metastatic cSCC cell lines (n=3) and NHEKs. Claudin‐11 was detected in cell‐cell contacts of primary cSCC cells in culture by indirect immunofluorescence analysis. Analysis of a large panel of tissue samples from sporadic UV‐induced cSCC (n=65), cSCC in situ (n=56), actinic keratoses (n=31), seborrhoeic keratoses (n=7) and normal skin (n=16) by immunohistochemistry showed specific staining for claudin‐11 in intercellular junctions of keratinizing tumor cells in well and moderately differentiated cSCCs, whereas no staining for claudin‐11 was detected in poorly differentiated tumors. The expression of claudin‐11 in cSCC cells was dependent on the activity of p38δ MAPK and knock‐down of claudin‐11 enhanced cSCC cell invasion. These findings provide evidence for the role of claudin‐11 in regulation of cSCC invasion and suggest loss of claudin‐11 expression in tumor cells as a biomarker for advanced stage of cSCC. 相似文献
978.
979.
Melanoma risk alleles are associated with downregulation of the MTAP gene and hypermethylation of a CpG island upstream of the gene in dermal fibroblasts 下载免费PDF全文
Antonella Sangalli Giovanni Malerba Gianpaolo Tessari Monica Rodolfo Macarena Gomez‐Lira 《Experimental dermatology》2017,26(8):733-736
Several association studies and GWAS on melanoma skin cancer risk have reported statistically significant signals on 9p21.3 region, where MTAP gene maps. None of the associated SNPs identified in these studies lie in the coding region of the gene and the causative relation of risk alleles with melanoma predisposition has not been elucidated. MTAP has a tumor suppressor activity and epigenetic silencing has been described in melanoma cell lines. In the present study, we show that melanoma risk alleles correlate with a MTAP allele‐specific hyper‐methylation and down‐regulation of gene expression. 相似文献
980.
Mireille Centlivre Maxime Petit Andrew J. Hutton Mélody Dufossée David Boccara Maurice Mimoun Angèle Soria Béhazine Combadière 《Experimental dermatology》2017,26(10):963-966
Development of new immunotherapeutic strategies relies on the ability to activate the right cells at the right place and at the right moment and on the capacity of these cells to home to the right organ(s). Skin delivery has shown high potency for immunotherapeutic administration. However, an adequate in vivo model of human skin immunity is still a critical bottleneck. We demonstrated here that the skin of human immune system mice is colonized by human hematopoietic cells, mainly human T cells and that complementation with human antigen‐presenting cells at the vaccination site allowed the induction of an immune response. 相似文献