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101.
福建省鼠伤寒沙门氏菌病原学特征变迁趋势 总被引:1,自引:0,他引:1
目的:了解福建省鼠伤寒沙门氏菌的病原学特征变迁情况。方法:采用噬菌体分型、质粒谱分析及耐药性测定的方法,对福建省1980~1995年15年鼠伤寒沙门氏菌的病原学特征进行动态监测。结果:福建省鼠伤寒沙门氏菌的噬菌体流行型别存在明显的变迁与更迭;质粒谱型有逐渐增多且分散趋势;菌株耐药率逐年大幅度上升,耐药谱逐年迅速增宽,多重耐药菌株逐年急剧增多,耐药现象日趋严重。结论:噬菌体分型、质粒谱分析及耐药性测定是监测福建省鼠伤寒沙门氏菌病原学特征变迁趋势的有效方法。 相似文献
102.
借助彩色多普勒频谱图,对糖尿病肾病患者肾脏叶间动脉血流参数进行分析,探讨该病中医分型的客观指标。方法:选择糖尿病肾病35例,将其分为气阴两虚及阴阳两虚组,于每位患者双肾叶间动脉测量:收缩期峰值血流速度(VS)、舒张期末血流速度(VD)、平均血流速度(MS)、搏动指数(PI)、阻力指数(RI)。结果:气阴两虚组PI、RI值明显高于正常组(P<0.01),阴阳两虚组PI、RI明显高于气阴两虚组(P<0.05);阴阳两虚组VD值高于气阴两虚组及正常组(P<0.01);气阴两虚组与正常组比较无统计学差异。结论:糖尿病肾病气阴两虚及阴阳两虚组中PI及RI,可以作为糖尿病肾病中医分型的客观指标。 相似文献
103.
A. Milde R. Kühl-Burmeister S. Ritz-Timme H.-J. Kaatsch 《International journal of legal medicine》1999,112(5):333-335
A chimera is an organism whose cells derive from two or more distinct zygote lineages. and therefore two different blood
cell populations circulate in one individual. To point out the potential pitfalls in forensic analysis, a set of triplets
(a girl and two boys) who revealed blood chimerism was investigated with four STR systems using PCR. The results indicated
that a DNA profile based on DNA extracted from blood can lead to a false determination because the band pattern of each triplet
contained a mixture of the original genotype and the genotype of the siblings. Additional investigations on biological materials
other than blood must be made in order to find out the real genetic characteristics of each child.
Received: 17 July 1998 / Received in revised form: 27 November 1998 相似文献
104.
福建地区河弧菌噬菌体分型研究 总被引:1,自引:0,他引:1
采用7 株噬菌体按 Gershman 的分型法,对从福建地区的人和外环境标本检出的271 株河弧菌作了分型试验。结果有223 株菌能被分型,分型率为8229 % ,共检出38 个不同噬菌体型,其中以600 、400 、740 、500 、640 、760 、020 和620 等8个型较常见,占总分型 菌的4908 % ;发现人源菌的常见型别与海产品源菌、水源菌和食品源菌的型别关系密切。 相似文献
105.
40所军队医院病种病例分型质量评价结果分析 总被引:17,自引:2,他引:15
应用病例分型质量费用监控管理软件和SAS6.12统计软件包,对40所军队医院50万份病例样本资料进行深入分析,结果显示:病例分型组合数据稳定,分析结果合理。 相似文献
106.
Summary The results of HLA-DQ typing from 42 routine forensic cases using the polymerase chain reaction (PCR) were analyzed regarding the reliability, discrimination efficiency and informative value of this system in a given case. The cases included stain typing from a variety of different substrates, i.e. blood and semen stains, mixed body fluids, single hairs, cigarette butts, material from fingernail scratches, as well as identification and paternity cases on postmortem and fixed tissue. A total of 125 individual stain and tissue samples were included. PCR amplification was achieved in 70% of these samples. In cases with mixed body fluids, e.g. sperm and vaginal cells from rape cases, DQ typing was always carried out successfully. However, only approx. 42% of all samples that could be typed were relevant regarding the inclusion or exclusion of a suspect. This was mostly due to the limited number of alleles that can be typed at the HLA-DQ locus or to the fact that the stain or hair samples did not originate from the perpetrator, but from the victim or from other persons not related to the crime. 相似文献
107.
Conventional teaching states that the retractile testis is a normal, physiological variant that descends spontaneously by puberty and requires no active treatment. Critical review of the literature, however, suggests that this complacent view may be inappropriate. Substantial overlap exists between the three seemingly separate entities of the late descending, the ascending and the retractile testes. This overlapping group probably accounts for the recently observed increased incidence of orchidopexies. Retractile testes that spend most of the time in an extrascrotal position are subject to the same adverse effects of higher temperatures as true undescended testes, regardless of whether they can be manipulated into the scrotum; what matters is where they actually reside most of the time. The evidence suggests that such retractile testes suffer similar pathological changes to true undescended testes if left to await spontaneous descent. Evidence is presented to support a radical, novel proposal that the retractile testis is a variant of the spectrum of pathological maldescended testes and requires active treatment. A new strategy is proposed for the management of this common pathology.
Correspondence to: D. W. Goh 相似文献
108.
D. Kabelitz M. L. da Silva Lobo K. Pechhold 《Journal of molecular medicine (Berlin, Germany)》1991,69(13):623-628
Summary The clinical success of organ transplantation depends to a large degree on the immunological acceptance of the grafted organ. This paper summarizes from an immunological point of view the recent progress that has been made to improve graft acceptance, and discusses some future aspects in the field. Over the last few years, major emphasis has been put on the development of new immunosuppressive drugs, including FK 506, rapamycin, and Deoxyspergualin. Together with monoclonal antibodies against defined T-cell surface antigens, there are now new and effective means available to prevent or treat rejection episodes. Progress has also been made in the field of HLA typing, where the introduction of molecular biology-based methods significantly increased the accuracy of HLA class II typing. The ultimate goal of transplantation immunology is the induction of (donor-) specific tolerance. While some protocols are effective in inducing peripheral tolerance in experimental animals, these regimens are at present not yet applicable in the clinical situation. To overcome the shortage of donor organs, alternative strategies are currently being considered. Among these, xenotransplantation may eventually prove successful, despite the massive immunological problems such as, e.g., the presence of preformed xenoreactive antibodies.Abbreviations CTL
cytolytic T lymphocyte
- HLA
human leukocyte antigen
- MHC
major histocompatibility complex
- PCR
polymerase chain reaction
- mAB
monoclonal antibody
- RFLP
restriction fragment length polymorphism
- TCR
T-cell receptor
Preprint of a lecture to be read at the 22nd Congress of the Gesellschaft für Nephrologie, Heidelberg, September 15–18, 1991 (Editor: Prof. Dr. E. Ritz, Heidelberg) 相似文献
109.
H. J. M. Völker-Dieben C. C. Kok-Van Alphen J. A. Oosterhuis G. Van Dorp A. Van Leeuwen 《Documenta ophthalmologica. Advances in ophthalmology》1977,44(1):39-48
In highly vascularized corneas the number of graft failures caused by irreversible rejections is higher than in non- or slightly vascularized corneas. The importance of antigen compatibility is demonstrated, especially in these high risk cases.Ten highly vascularized corneas were grafted with HLA-matched donor material; only one reversible rejection was seen in this group.Nine non- or slightly vascularized corneas were grafted with donor material chosen at random. Retrospective HLA matching was performed. Three irreversible rejections were seen in this group. The number of HLA incompatibilities was high. 相似文献
110.
益气化瘀补肾法对颈椎病动物椎间盘病理变化与Ⅱ型胶原mRNA表达的影响 总被引:5,自引:0,他引:5
目的 :观察益气化瘀补肾法对颈椎病动物退变椎间盘病理变化及髓核Ⅱ型胶原mRNA表达的影响。方法 :把健康成年新西兰大白兔随机分为益气化瘀补肾组、消炎痛组、模型对照组和正常对照组 ,运用静力平衡失调颈椎病动物模型 ,造成动物椎间盘的退变 ,然后分别喂以相应药物或医用淀粉胶囊 ,观察24周后 ,取颈6/7椎间盘 ,用HE染色法观测椎间盘组织病理变化 ,用生物素标记原位杂交法观测椎间盘髓核组织内细胞Ⅱ型胶原mRNA的表达 ,并运用图像分析仪对其进行数据转换 ,采用SPSS统计软件分析。结果 :益气化瘀补肾法对退变椎间盘病理变化的影响不显著 ,但对椎间盘髓核组织内Ⅱ型胶原mRNA表达的影响有显著作用。结论 :益气化瘀补肾法对颈椎病动物退变椎间盘髓核组织胶原的形成过程的环节有正面影响。 相似文献