全文获取类型
收费全文 | 374968篇 |
免费 | 43501篇 |
国内免费 | 14590篇 |
专业分类
耳鼻咽喉 | 3752篇 |
儿科学 | 6344篇 |
妇产科学 | 6922篇 |
基础医学 | 46218篇 |
口腔科学 | 7139篇 |
临床医学 | 30877篇 |
内科学 | 44970篇 |
皮肤病学 | 5588篇 |
神经病学 | 10193篇 |
特种医学 | 10583篇 |
外国民族医学 | 343篇 |
外科学 | 44402篇 |
综合类 | 53223篇 |
现状与发展 | 83篇 |
一般理论 | 3篇 |
预防医学 | 15278篇 |
眼科学 | 3614篇 |
药学 | 27228篇 |
181篇 | |
中国医学 | 10480篇 |
肿瘤学 | 105638篇 |
出版年
2024年 | 1064篇 |
2023年 | 6799篇 |
2022年 | 12744篇 |
2021年 | 17072篇 |
2020年 | 15828篇 |
2019年 | 14459篇 |
2018年 | 14332篇 |
2017年 | 15023篇 |
2016年 | 15997篇 |
2015年 | 18345篇 |
2014年 | 26545篇 |
2013年 | 27444篇 |
2012年 | 22767篇 |
2011年 | 24101篇 |
2010年 | 18686篇 |
2009年 | 18645篇 |
2008年 | 19380篇 |
2007年 | 19072篇 |
2006年 | 17047篇 |
2005年 | 14885篇 |
2004年 | 12784篇 |
2003年 | 10845篇 |
2002年 | 8977篇 |
2001年 | 7961篇 |
2000年 | 6598篇 |
1999年 | 5808篇 |
1998年 | 5251篇 |
1997年 | 4740篇 |
1996年 | 4073篇 |
1995年 | 3641篇 |
1994年 | 3118篇 |
1993年 | 2543篇 |
1992年 | 2167篇 |
1991年 | 1975篇 |
1990年 | 1541篇 |
1989年 | 1410篇 |
1988年 | 1283篇 |
1987年 | 1062篇 |
1986年 | 933篇 |
1985年 | 1176篇 |
1984年 | 1030篇 |
1983年 | 715篇 |
1982年 | 736篇 |
1981年 | 627篇 |
1980年 | 535篇 |
1979年 | 391篇 |
1978年 | 267篇 |
1977年 | 211篇 |
1976年 | 162篇 |
1975年 | 87篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
我院1989年至1994年共行子宫颈癌广泛切除术和盆腔淋巴结清扫术39例,其中28例行术前放射治疗,19例临床诊断为Ⅱb,随着手术技术的提高和术前放射治疗的配合,子宫颈癌的手术适应症的选择,可以扩大至Ⅱb,不增加手术的并发症,并具有一定的优点。 相似文献
992.
993.
本文报告5例喉癌颈清扫术,对其适应症、手术方式等进行了初步分析。认为CN_(1,2),无论病理LN是否阳性均应行ND。CN_3者ND要慎重考虑。CN_0一般不施行ND,除声门上癌或声门癌侵及声门上区时例外。术式以FND为宜。 相似文献
994.
曹之言 《重庆医科大学学报》1988,(4)
作者报道28例经手术及病理证实的肺部囊性病变,其中21例为先天性,7例为后天性.x线表现可分为:①单发气囊腔.②多发性气囊腔.③单发液囊腔.④单或多发液气囊腔,内有液平面.⑤肺隔离症.讨论了形成机理以及与肺结核,肺脓肿,肺癌,转移性肺肿瘤,肺包虫囊肿等的x线鉴别诊断 相似文献
995.
Wallin C.-J. B.; Jacobson S. H.; Leksell L. G. 《Nephrology, dialysis, transplantation》1996,11(11):2269-2275
It has been postulated that patients with chronic renal failure,even in the absence of cardiopulmonary symptoms, accumulateinterstitial pulmonary fluid, which is removed by haemodialysis.To test this hypothesis we used the indocyanine green (ICG)-heavywater double indicator dilution method to measure lung water,cardiac output, and central blood volume in relation to haemodialysis.Ten uraemic patients, without cardiopulmonary symptoms, wereinvestigated at the beginning and end, and 2 h after, a regulardialysis session. A group of 18 surgical patients about to undergoelective abdominal surgery served as controls. Despite normalgas exchange, central blood volume, and cardiac output at thestart of dialysis the mean (SD) lung water was significantlyhigher than in the control group [4.8 (0.9) compared with 3.6(0.7) ml/kg, P<0.001]. There was no correlation between weightgain between sessions of dialysis and the magnitude of lungwater at the start of dialysis. Lung water decreased (P <0.001)to the level of the control group in response to dialysis. Therewas no correlation between weight loss and reduction in lungwater induced by dialysis. In conclusion, we have verified thepresence of subclinical pulmonary oedema which was removed bydialysis in a group of patients with established renal failure.The variations in lung water cannot be explained by hydrostaticmechanisms alone. 相似文献
996.
胃粘膜上皮“适应性细胞保护”机制防止胃肿瘤发生的作用 总被引:4,自引:0,他引:4
投用致癌剂的对照组其胃肿瘤发生率为22.2%。若同时给予40%Z醇液空腹灌胃,则胃肿瘤发生率达55.9%。如在给乙醇液前15分钟,先给予4%的辣椒煎液灌胃,则胃肿瘤发生率只有20.0%,相近于对照组的水平(后2组差别有极显著意义,P<0.01)。这种给损伤剂(乙醇)之前先给予微刺激剂(辣椒)所产生的胃粘膜的保护作用,是通过促使胃粘膜上皮细胞合成内源性前列腺素(PGs)来实现的,是一种“适应性细胞保护”机制。这种保护胃粘膜的作用可降低胃肿瘤的发生率。 相似文献
997.
International comparisons show that populations having a high consumption of fish experience low incidence of breast cancer. We compared death rates from breast cancer among socioeconomic groups in a prospective study of 533,276 Norwegian women aged 35–54 years who were followed from 1970 through 1985. Compared with the reference group (wives of unskilled workers) the fishermen's wives had a decreased risk of breast cancer with a relative risk (RR) of 0.67 (95% confidence interval [CI]=0.47–0.94) adjusted for age and the number of children. Among fishermen's wives who were parous, adjustment for age at first birth gave an RR of 0.62 (CI=0.43–0.91). This study supports the hypothesis that certain aspects of diet, i. e., fish consumption, may be associated with lower breast-cancer mortality.Drs Lund and Bønaa are with the Institute of Community Medicine, University of Tromsø, Tromsø, Norway. Address correspondence to Dr Lund, Institute of Community Medicine, University of Tromsø, N-9037 Tromsø, Norway. 相似文献
998.
Caroline S. Drugan rea Stone Steve M. Game Stephen S. Prime 《Journal of oral pathology & medicine》1997,26(7):327-333
This study examined the mitogenic response to keratinocyte growth factor (KGF) of normal and tumour-derived human oral keratinocytes in which the degree of cellular differentiation was known and in contiguous fibroblast cultures derived from the malignant epithelial cultures. Keratinocytes, but not fibroblasts, were stimulated by KGF. There by demonstrating epithelial target cell specificity of the ligand. KGF-induced stimulation of the tumour-derived keratinocytes cultured in the absence of the 3T3 fibroblast support broadly correlated with the degree of cellular differentiation; well-differentiated keratinocytes were stimulated more by KGF than their less differentiated counterparts. Malignant oral keratinocytes expressed KGF cell surface receptors (KD 451-709 pM; receptors/cell 2306-413645), but KGF receptor mRNA did not correlate with either KGF-induced mitogenesis or the degree of epithelial cell differentiation. When the tumour-derived keratinocytes were cultured in the presence of 3T3 fibroblasts, the mitogenic response to KGF was comparable to normal epithelial cells. The results suggest that KGF-mediated growth stimulation may not be significant in providing a selective advantage for the growth of malignant keratinocytes. 相似文献
999.
Adherence of Staphylococcus aureus to cultures of human peritoneal mesothelial cells 总被引:1,自引:0,他引:1
Glancey G.; Cameron J. S.; Ogg C.; Poston S. 《Nephrology, dialysis, transplantation》1993,8(2):157-162
Strains of Staphylococcus aureus, isolated from the effluentof patients with peritonitis on CAPD (continuous ambulatoryperitoneal dialysis), adhered well to both cultured human mesothelialcells and to fibronectin, but not to laminin or gelatin. Mesothelialcells grown in medium M199 exhibited more surface fibronectincompared to cells grown in MEM-Dval and demonstrated higherlevels of S. aureus adherence. Soluble fibronectin concentrations up to lOµg/ml increasedthe adherence of S. aureusto cultured mesothelial cells. Thedose-response curve was consistent with the binding of fibronectinto a saturable receptor of apparent dissociation constant (KD)= 1.7xlO10 M. This corresponds closely to the KD (2xlO10M) of the staphylococcal fibronectin-binding protein. S. aureus adherence was increased following the preincubationof mesothelial cell monolayers with interleukin-1 and was maximalafter 6 h preincubation. Treating mesothelial cells with interferon-gammafor 4872 h reduced the adherence of S. aureus. 相似文献
1000.
经电镜观察,慢活肝中主要为淋巴细胞及单核巨噬细胞浸润。淋巴细胞分3型,通过4种方式与肝细胞接触,可能代表杀伤肝细胞的动态过程。与肝细胞接触的主要为起细胞毒作用的T_8~+Ⅱ型淋巴细胞及单核巨噬细胞。多数T_4~+淋巴细胞为Ⅰ型淋巴细胞,可能为T辅助细胞。在肝细胞损伤中,淋巴细胞及单核巨噬细胞均起重要作用。 相似文献