全文获取类型
收费全文 | 47773篇 |
免费 | 3852篇 |
国内免费 | 1411篇 |
专业分类
耳鼻咽喉 | 186篇 |
儿科学 | 895篇 |
妇产科学 | 991篇 |
基础医学 | 4614篇 |
口腔科学 | 903篇 |
临床医学 | 5588篇 |
内科学 | 10386篇 |
皮肤病学 | 318篇 |
神经病学 | 785篇 |
特种医学 | 605篇 |
外国民族医学 | 11篇 |
外科学 | 1974篇 |
综合类 | 7190篇 |
现状与发展 | 9篇 |
预防医学 | 6252篇 |
眼科学 | 168篇 |
药学 | 6306篇 |
13篇 | |
中国医学 | 1519篇 |
肿瘤学 | 4323篇 |
出版年
2024年 | 124篇 |
2023年 | 660篇 |
2022年 | 1694篇 |
2021年 | 2096篇 |
2020年 | 1608篇 |
2019年 | 1554篇 |
2018年 | 1594篇 |
2017年 | 1536篇 |
2016年 | 1840篇 |
2015年 | 2053篇 |
2014年 | 3209篇 |
2013年 | 3889篇 |
2012年 | 3409篇 |
2011年 | 3551篇 |
2010年 | 2737篇 |
2009年 | 2509篇 |
2008年 | 2656篇 |
2007年 | 2591篇 |
2006年 | 2214篇 |
2005年 | 1904篇 |
2004年 | 1579篇 |
2003年 | 1205篇 |
2002年 | 970篇 |
2001年 | 877篇 |
2000年 | 690篇 |
1999年 | 591篇 |
1998年 | 484篇 |
1997年 | 455篇 |
1996年 | 380篇 |
1995年 | 303篇 |
1994年 | 290篇 |
1993年 | 219篇 |
1992年 | 213篇 |
1991年 | 179篇 |
1990年 | 130篇 |
1989年 | 128篇 |
1988年 | 89篇 |
1987年 | 104篇 |
1986年 | 65篇 |
1985年 | 114篇 |
1984年 | 75篇 |
1983年 | 46篇 |
1982年 | 73篇 |
1981年 | 57篇 |
1980年 | 52篇 |
1979年 | 40篇 |
1978年 | 27篇 |
1977年 | 37篇 |
1976年 | 36篇 |
1975年 | 26篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
Patients with non‐small cell lung cancer (NSCLC) containing ROS1 fusions can have a marked response to the ROS1‐targeted tyrosine kinase inhibitors (TKIs), such as crizotinib. Common resistance mechanisms of ROS1‐fusion targeted therapy are acquired mutations in ROS1. Along with the use of next‐generation sequencing in the clinical management of patients with NSCLC during sequential targeted therapy, many mechanisms of acquired resistance have been discovered in patients with activated tyrosine kinase receptors. Besides acquired resistance mutations, bypass mechanisms of resistance to epidermal growth factor receptor (EGFR)‐TKI treatment are common in patients with EGFR mutations. Here we describe a patient with metastatic lung adenocarcinoma with CD74‐ROS1 fusion who initially responded to crizotinib and then developed resistance by the acquired mutation of D1228N in the MET kinase domain, which showed short‐term disease control for cabozantinib.Key Points
- The D1228N point mutation of MET is an acquired mutation for crizotinib resistance.
- The patient obtained short‐term clinical benefit from cabozantinib therapy after resistance to crizotinib.
- The clinical use of next‐generation sequencing could maximize the benefits of precision medicine in patients with cancer.
992.
993.
Roberto Codella Lucio Della Guardia Ileana Terruzzi Anna Solini Franco Folli Elena Maria Varoni Antonio Carrassi Livio Luzi 《Nutrition, metabolism, and cardiovascular diseases : NMCD》2021,31(8):2199-2209
While the beneficial impact of physical activity has been ascertained in a variety of pathological scenarios, including diabetes and low-grade systemic inflammation, its potential remains still putative for periodontal health. Periodontal disease has been associated with inflammatory systemic alterations, which share a common denominator with type 2 diabetes mellitus and cardiovascular disease. Physical exercise, along with nutritional counseling, is a cornerstone in the treatment and prevention of type 2 diabetes, also able to reduce the prevalence of periodontal disease and cardiovascular risk. In addition, considering the higher incidence of periodontitis in patients with type 2 diabetes compared to healthy controls, the fascinating research question would be whether physical activity could relieve the inflammatory pressure exerted by the combination of these two diseases. This multi-disciplinary viewpoint discusses available literature in order to argument the hypothesis of a “three–way relationship” linking diabetes, periodontitis, and physical activity. 相似文献
994.
《Journal of chemotherapy (Florence, Italy)》2013,25(3):261-262
AbstractA malignant, primary brain tumor developed as Second Malignant Neoplasm (SMN) in 2/490 long-term-survivor osteosarcoma patients treated at our Institute over a 20-yr period. They developed the brain tumor (one astrocytoma and one glioblastoma) 3 and 5 yr after treatment, (chemotherapy and surgery), for localized osteosarcoma of the extremity. 相似文献
995.
Vidthiya Menon Rebecca Davis Nick Shackel Bjorn A. Espedido Alicia G. Beukers Slade O. Jensen Sebastiaan J. van Hal 《Diagnostic microbiology and infectious disease》2018,90(2):120-122
Daptomycin β-Lactam combination therapy offers “protection” against daptomycin non-susceptibility (DNS) development in Enterococcus faecium. We report failure of this strategy and the importance of source control. Mutations were detected in the LiaF and cls genes in DNS isolates. A single DNS isolate contained an unrecognized mutation, which requires confirmation. 相似文献
996.
Lawrence G. Rudski Luna Gargani William F. Armstrong Patrizio Lancellotti Steven J. Lester Ekkehard Grünig Michele DAlto Meriam ?str?m Aneq Francesco Ferrara Rajeev Saggar Rajan Saggar Robert Naeije Eugenio Picano Nelson B. Schiller Eduardo Bossone 《Journal of the American Society of Echocardiography》2018,31(5):527-550.e11
997.
Brian K. Heimbuch William H. Wallace Charles L. Balzli Michelle L. Laning Delbert A. Harnish 《Journal of occupational and environmental hygiene》2016,13(2):D11-D15
Nosocomial infections pose a significant and escalating threat to both patients and healthcare workers (HCWs). By their nature, hospitals induce antibiotic resistance in virulent and commensal strains, leading to increasingly severe hospital-acquired infections. This study measured environmental exposure experienced by domestic staff cleaning vacated patient rooms of a community hospital to bacteria in ambient bioaerosols. While they cleaned the room, participants wore an N95 filtering facepiece respirator (FFR), from which coupons were cut and bacteria were extracted, cultured and enumerated. Extrapolation to the full area of the respirator yielded measured exposures of 0.2–1.4 × 104 colony-forming units/hour, of which ~97% collected on the front layer of the N95, suggesting a possible role for minimal respiratory protection in nonpatient environments. Random resistance testing of 1.6% of the isolates showed that ~70% of both Gram-positive and Gram-negative organisms exhibited resistance to oxacillin and ~9% of the Gram-positives displayed resistance to vancomycin. These data provide an estimate for mask bioaerosol loading that can be used in risk modeling and to refine strategies for reuse of FFRs during critical shortages. 相似文献
998.
999.
1000.
Ahmed A. Mourad Gehan H. Heeba Ashraf Taye Mohamed A. El‐Moselhy 《Fundamental & clinical pharmacology》2013,27(5):489-497
Obesity is often associated with chronic inflammatory state which contributes to the development of insulin resistance (IR) and type 2 diabetes mellitus (T2DM). This study investigated the effects of single and combined administration of atorvastatin (ATOR, lipid‐lowering drug) and losartan (LOS, angiotensin receptor antagonist) on metabolic disorders and inflammatory status that are implicated in the development of T2DM with the use of pioglitazone (PIO) as a standard antidiabetic drug. T2DM was induced in male rats by high‐fat diet (HFD) feeding for 16 weeks. Oral administrations of ATOR (10 mg/kg), LOS (20 mg/kg), PIO (3 mg/kg), their binary combinations, or vehicle were started in the last 4 weeks. Fasting serum glucose, oral glucose tolerance, fasting serum insulin, IR, serum lipid profile, serum TNF‐α and body composition index were determined. Results showed that all drugs and their combinations had positive impact effect on all measured parameters, and better results were achieved from binary drug combinations than administration of each drug alone. Combination of PIO with either ATOR or LOS provided better improvements on T2DM‐associated metabolic abnormalities and inflammatory status with respect to each drug alone. However, the most pronounced effects of drugs and their combinations regarding the above parameters were attributed to LOS + PIO combination. In conclusion, this study indicates that combination of ATOR + PIO and, in particular, LOS + PIO can be used as promising effective therapies in the management of HFD‐induced T2DM. This concept may be attributed to the combined effects of the respective monotherapies to improve lipid profile, insulin sensitivity, and TNF‐α level. 相似文献