全文获取类型
收费全文 | 36609篇 |
免费 | 2912篇 |
国内免费 | 796篇 |
专业分类
耳鼻咽喉 | 467篇 |
儿科学 | 732篇 |
妇产科学 | 757篇 |
基础医学 | 3060篇 |
口腔科学 | 552篇 |
临床医学 | 3306篇 |
内科学 | 6753篇 |
皮肤病学 | 653篇 |
神经病学 | 1009篇 |
特种医学 | 1595篇 |
外国民族医学 | 22篇 |
外科学 | 5857篇 |
综合类 | 3462篇 |
现状与发展 | 2篇 |
预防医学 | 2189篇 |
眼科学 | 596篇 |
药学 | 2370篇 |
8篇 | |
中国医学 | 394篇 |
肿瘤学 | 6533篇 |
出版年
2024年 | 62篇 |
2023年 | 1031篇 |
2022年 | 1535篇 |
2021年 | 2442篇 |
2020年 | 2026篇 |
2019年 | 2194篇 |
2018年 | 2013篇 |
2017年 | 1404篇 |
2016年 | 1233篇 |
2015年 | 1218篇 |
2014年 | 2446篇 |
2013年 | 2222篇 |
2012年 | 1650篇 |
2011年 | 1894篇 |
2010年 | 1510篇 |
2009年 | 1531篇 |
2008年 | 1672篇 |
2007年 | 1665篇 |
2006年 | 1323篇 |
2005年 | 1212篇 |
2004年 | 1019篇 |
2003年 | 886篇 |
2002年 | 756篇 |
2001年 | 589篇 |
2000年 | 510篇 |
1999年 | 449篇 |
1998年 | 414篇 |
1997年 | 340篇 |
1996年 | 294篇 |
1995年 | 268篇 |
1994年 | 269篇 |
1993年 | 211篇 |
1992年 | 228篇 |
1991年 | 206篇 |
1990年 | 177篇 |
1989年 | 157篇 |
1988年 | 152篇 |
1987年 | 130篇 |
1986年 | 124篇 |
1985年 | 147篇 |
1984年 | 130篇 |
1983年 | 88篇 |
1982年 | 102篇 |
1981年 | 82篇 |
1980年 | 77篇 |
1979年 | 61篇 |
1978年 | 46篇 |
1977年 | 52篇 |
1976年 | 31篇 |
1975年 | 13篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
21.
22.
Xin Yi Wong Andrew Qi Jun Lim Qianyu Shen John Whay Kuang Chia Min Hoe Chew Wah Siew Tan 《Current medical research and opinion》2020,36(10):1677-1686
Abstract
Objective
Ras wild-type metastatic colorectal cancers (mCRC) may be treated with anti-vascular endothelial growth factor (VEGF) or anti-epidermal growth factor receptor (EGFR) agents. We aim to estimate patients’ preferences for mCRC treatment and relative importance of cost, efficacy improvement, avoidance of side effects and therapy convenience, and relative uptake between profiles that resemble Bevacizumab (anti-VEGF) and Cetuximab (anti-EGFR), two commonly prescribed mCRC targeted therapies. 相似文献23.
24.
25.
26.
Mark Verrill 《Surgery (Oxford)》2019,37(3):181-185
Multimodality primary therapies for breast cancer combined with earlier detection have led to a sharp decline in the death rate from breast cancer in the UK over the last 40 years in the face of a rising incidence. The latest UK statistics from Cancer Research UK report 55,122 new cases of breast cancer in 2015 with 11,563 deaths from breast cancer recorded in 2016. Crudely, this equates to a cure rate of around 80% for all comers and demonstrates a clear improvement in outcome with 50,285 new cases in 2011 and 11,716 deaths in 2012. Despite this good news, there are still significant numbers of women (and men) who suffer from either a local recurrence or metastatic disease following apparently successful treatment for early breast cancer (Stage I to III). Only a minority of individuals, 6.6% with the stage recorded at diagnosis, present with stage IV disease. This review considers the treatment options available to individuals with locally recurrent and advanced breast cancer (ABC). 相似文献
27.
28.
29.
Sentinel lymph node biopsy for 102 patients with primary cutaneous melanoma at a single Japanese institute 下载免费PDF全文
Masaki Otsuka Osamu Yamasaki Tatsuya Kaji Keiji Iwatsuki Kenji Asagoe 《The Journal of dermatology》2015,42(10):954-961
Sentinel lymph node biopsy (SLNB) is a widely accepted standard procedure for patients with clinically localized melanoma. Melanoma prevalence and Clark's subtype differ between Asians and Caucasians. Here, we evaluated our experience on SLNB for cutaneous melanoma in a Japanese population. SLNB was performed for patients with melanoma between July 2000 and June 2014. We retrospectively analyzed 102 patients regarding association of clinicopathological features with sentinel lymph node (SLN) status, melanoma‐specific survival (MSS) and disease‐free survival (DFS). A positive SLN was significantly associated with primary Breslow thickness. Compared with 43 patients with negative SLN, 59 patients with positive SLN had significantly shorter MSS (5‐year survival rate, 94.3% vs 63.2%; P = 0.0002) and DFS (5‐year survival rate, 92.7% vs 63.4%; P = 0.0004). According to our subgroup analyses, nine patients with positive non‐SLN had significantly shorter MSS compared with 32 patients with negative non‐SLN (5‐year survival rate, 32.4% vs 68.5%; P = 0.0273). The survival of 51 Japanese patients with acral lentiginous melanoma (ALM) was not inferior to the survival of patients with other Clark's subtype. Breslow thickness is an important factor for both MSS and DFS, and the status of SLN is the most predictive prognostic factor in Japanese patients with clinically localized melanomas, as in case of Caucasians. Features of ALM may be different between Asians and Caucasians. 相似文献
30.
《Mayo Clinic proceedings. Mayo Clinic》2022,97(12):2271-2281
ObjectiveTo investigate the association between type 1 diabetes mellitus (T1D) and type 2 diabetes mellitus (T2D) with risk of sudden cardiac arrest (SCA).MethodsIn a prospective community-based study of SCA from February 1, 2002, through November 30, 2019, we ascertained 2771 cases age 18 years of age or older and matched them to 8313 controls based on geography, age, sex, and race/ethnicity. We used logistic regression to evaluate the independent association between diabetes, T1D, T2D, and SCA.ResultsPatients had a mean age of 64.5±15.9 years, were 33.3% female and 23.9% non-White race. Overall, 36.7% (n=1016) of cases and 23.8% (n=1981) of controls had diabetes. Among individuals with diabetes, the proportion of T1D was 6.5% (n=66) among cases and 2.0% among controls (n=40). Diabetes was associated with 1.5-times higher odds of SCA. Compared with those without diabetes, the odds ratio and 95% CI for SCA was 4.36 (95% CI, 2.81 to 6.75; P<.001) in T1D and 1.45 (95% CI, 1.30 to 1.63; P<.001) in T2D after multivariable adjustment. Among those with diabetes, the odds of having SCA were 2.41 times higher in T1D than in T2D (95% CI, 1.53 to 3.80; P<.001). Cases of SCA with T1D were more likely to have an unwitnessed arrest, less likely to receive resuscitation, and less likely to survive compared with those with T2D.ConclusionType 1 diabetes was more strongly associated with SCA compared with T2D and had less favorable outcomes following resuscitation. Diabetes type could influence the approach to risk stratification and prevention of SCA. 相似文献