冠脉内超声成像在冠状动脉内支架植入术中的应用

目的　探讨冠脉内超声成像 (ICUS)在冠心病支架植入术治疗中的作用。方法　对 88例经皮冠脉腔内成形术 (PTCA)同时行冠状动脉内支架植入治疗的患者进行评价。在支架植入前 ,应用ICUS测量病变血管的最小腔径和最小腔面积 ;在支架植入后 ,测量支架扩张后的最小直径和支架面积 ,确定扩张后支架是否贴壁和支架扩张是否充分。结果　 88例支架植入术患者的 97枚支架ICUS结果 :植入后支架的平均直径为 (3 .12±0 .16 )mm ,平均面积为 (6 .85± 0 .76 )mm2 。其中 42例支架植入前后斑块面积的配对 t检验显示支架植入前后靶血管腔面积和斑块面积均有显著性差异 (P <0 .0 0 1)。扩张后的支架直径为 (3 .0 9± 0 .0 9)mm ,支架面积为(6 .75± 0 .6 7)mm2 。 8例支架未充分扩展 ,3例贴壁欠佳 ,行再次扩张 ,占支架植入患者的 12 .5 %。结论　冠脉内超声可清晰显示冠脉内支架 ,支架植入前可确定血管直径 ,帮助选择支架的大小 ;植入后可精确测量支架的大小和面积 ,同时可观察支架贴壁情况 ,评价支架扩张是否充分。冠脉内超声是目前指导支架植入 ,评价支架植入效果的最佳手段     

超声引导下微波介入治疗中晚期肝癌的临床研究

目的 进一步探讨超声引导下微波介入治疗肝癌的可行性和疗效。方法 对４３例中晚期肝癌患者进行超声引导下微波治疗。采用分次多点多部位由深到浅低功率分段凝固,输出功率３０￣６０Ｗ,作用时间２００￣１８００ｓ。     

Experimental study of the antitumor effect of phosphorus-32 glassmicrospheres on the tumor loaded nude mice

AIM To evaluate the pharmacological effect of phosphorus-32 glass microspheres (32p-GMS) injected intothe implanted human liver cancer cell mass in nude mice.METHODS Fifty-two Balb/c tumor loaded nude mice were allocated into treatment group (n =38) andcontrol group (n = 14), in the former group different doses of 32p-GMS were injected into the tumor mass,while in the latter group 31 P-GMS or no treatment were given instead of 32 P-GMS. After dynamicallyobserving the growth of tumor for d 3 - d 28, the experimental animals were killed in batches, the tumor andits nearby tissues were examined by light and electronic microscopy.RESULTS In comparing with the control group, the treatment group showed the tumor inhibiting rates of59.7% -93.6% (Variance analysis of the mean weight of different doses and control group after square rootcorrection, F= 579.62, P<0.01). As the tumor mass attained the absorbed dose of 7320Gy, the tumor cellswere completely destroyed and at this maximal dose in one case, the epithelial tissue neighboring to this massshowed the signs of metaplasia. When the absorbed doses ranged from 1830Gy to 3660Gy, most of the tumorcells showed the evidences of injury or necrosis, and some well differentiated tumor cells appeared. As theabsorbed dose being 366Gy or less, some tumor cells remained in active proliferative stage with a lot offibroblasts and lymphocytes presented in the neighboring interstitial tissues.CONCLUSION When the experimental model of implanted human liver cancer cells received 32p-GMS of1830Gy-3660Gy, it produces excellent anticancer action without any injury to the normal neighboringtissues and the prominent anticancer effect is found within d 3 after intratumor injection.     

血管内介入治疗联合高压氧对脑梗死患者氧化应激指标及脑血流动力学的影响

目的 探讨血管内介入治疗联合高压氧对脑梗死患者氧化应激指标及脑血流动力学的影响.方法 选取2018年10月至2020年10月收治的76例脑梗死患者为研究对象,以随机数字法将其分为对照组和观察组,各38例.对照组采用血管内介入治疗,观察组在对照组基础上联合高压氧治疗.比较两组患者的氧化应激指标、脑血流动力学指标、神经功能...     

In memoriam Professor Luc Picard (1937–2021)

Professor Luc Picard was one of the pioneers of Interventional Neuroradiology     

大肠癌肝转移瘤DSA表现和介入治疗

目的　探讨大肠癌不同类型肝转移瘤DSA表现和介入治疗效果评价。方法　回顾分析 10 6例大肠癌肝转移瘤DSA表现 ,介入治疗方案选择和效果评价。结果　 10 6例中 ,单结节和少结节转移灶 (病灶≤ 3个 ) 3 0例 ,占 2 8.3 % ;DSA造影表现以富血供为主 ,多发转移瘤 76例 ,占 71.7% ;DSA造影表现以乏血供为主单发富血供转移瘤行化疗栓塞 ,余经动脉药盒 (PCS)行规律化疗灌注 ,前者生存期较后者明显延长。结论　大肠癌肝转移瘤以多发、乏血供的转移为主 ,介入治疗为肠癌肝转移瘤提供了一条较好的治疗途径。     

血管介入治疗急诊难治性产后出血6例

目的:探讨难治性产后出血急诊血管介入止血的临床价值。方法:对6例难治性产后出血,出血量1700ml～2800ml,出血原因为软产道损伤、子宫收缩乏力、胎盘因素、凝血机能障碍,经临床药物治疗无效,难以控制出血者行急诊血管介入止血,采用超选择髂内动脉插管,造影明确诊断后用经高温、高压消毒的明胶海绵颗粒栓塞靶血管。结果:插管成功率100%,栓塞后立即止血5例(56),无效1例(16)。结论:急诊介入栓塞止血安全、迅速、微创、有效,是治疗产后大出血的理想方法,不仅能挽救生命,而且能避免外科手术而保留子宫。     

Interventional catheterization decreases plasma levels of atrial natriuretic peptide (ANP) in children with congenital heart defects

Atrial natriuretic peptide (ANP) is one of the cardiac peptides implicated in volume and sodium homeostasis. We investigated the effect of interventional catheterization on plasma levels of ANP, aldosterone, and cortisol in 28 children with various congenital heart defects (CHD). Patients were divided by age into two groups: group A - infants and children over 3 months of age (n = 22), and group B - newborns (n = 6). These were compared to age-matched control groups. In group A, interventions included pulmonic valvotomy (n = 8), aortic valvotomy (n = 4), balloon angioplasty of native coarctation of the aorta (n = 3), balloon dilatation of the mitral valve (n = 1), and Rashkind double umbrella closure of patent ductus arteriosus (n = 6). Group B interventions included pulmonic valvotomy (n = 3), aortic valvotomy (n = 1), and balloon atrial septosomy (n = 2). In group A, mean ANP levels were markedly higher than in age-matched controls (125.2 ± 15.8 vs. 24.6 ± 4.6 pg/ml) (P <0.0001), and decreased immediately after intervention (75.6 ± 11.4 pg/ml, P <0.02), and more markedly on follow-up (42.9 ± 5.0 pg/ml, P <0.0001). In group B (newborns), mean basal plasma levels were high before and after intervention and were not different from age-matched controls (243 ± 42.1 vs. 220.8 ± 16.2 pg/ml). There was a significant decrease on follow-up measurement (62.1 ± 12.7 pg/ml, P <0.005). In both groups, plasma cortisol levels increased significantly immediately following catheterization (P <0.02), and normalized on follow-up. Basal aldosterone levels were normal in group A and high in Group B (9.9 ± 3.8 vs. 167.6 ± 16.9 ng/dl) (P <0.001). It is suggested that plasma ANP levels are increased in children with CHD, without overt heart failure, and decrease significantly following successful intervention. In newborns with CHD, the physiological high ANP levels obscure the effect of the CHD. Cathet. Cardiovasc. Diagn. 45:27–32, 1998. © 1998 Wiley-Liss, Inc.     

Single coronary artery complicating stent implantation for homograft stenosis in tetralogy of Fallot

Successful stent implantation for conduit stenosis has been described; however, this procedure may be complicated by compression of adjacent structures during expansion. We report on a rare case of a single right coronary artery system complicating stent implantation for relief of homograft stenosis in tetralogy of Fallot. Cathet. Cardiovasc. Diagn. 42:405–407, 1997. © 1997 Wiley-Liss, Inc.     

介入诊断与治疗肺癌的现状与挑战

肺癌全球发病率位居第二、死亡率位居第一,多数肺癌患者确诊时已为中晚期,失去接受根治性外科切除术的机会。随着人口老龄化,高龄或具有严重合并症患者日渐增多,因无法耐受传统手术及全身治疗而预后较差。近年来,介入技术在诊断与治疗肺癌中的应用渐趋普及,具有微创、有效、并发症少、耐受性好等优点,但仍存在诸多问题及争议。本文围绕介入诊断与治疗肺癌的现状及挑战进行述评。