全文获取类型
收费全文 | 2746篇 |
免费 | 404篇 |
国内免费 | 79篇 |
专业分类
耳鼻咽喉 | 19篇 |
儿科学 | 74篇 |
妇产科学 | 78篇 |
基础医学 | 442篇 |
口腔科学 | 33篇 |
临床医学 | 224篇 |
内科学 | 309篇 |
皮肤病学 | 27篇 |
神经病学 | 163篇 |
特种医学 | 116篇 |
外国民族医学 | 2篇 |
外科学 | 385篇 |
综合类 | 289篇 |
预防医学 | 159篇 |
眼科学 | 12篇 |
药学 | 138篇 |
3篇 | |
中国医学 | 116篇 |
肿瘤学 | 640篇 |
出版年
2024年 | 10篇 |
2023年 | 48篇 |
2022年 | 93篇 |
2021年 | 174篇 |
2020年 | 160篇 |
2019年 | 150篇 |
2018年 | 162篇 |
2017年 | 141篇 |
2016年 | 157篇 |
2015年 | 135篇 |
2014年 | 228篇 |
2013年 | 214篇 |
2012年 | 169篇 |
2011年 | 149篇 |
2010年 | 135篇 |
2009年 | 122篇 |
2008年 | 152篇 |
2007年 | 108篇 |
2006年 | 110篇 |
2005年 | 82篇 |
2004年 | 61篇 |
2003年 | 50篇 |
2002年 | 60篇 |
2001年 | 46篇 |
2000年 | 33篇 |
1999年 | 33篇 |
1998年 | 28篇 |
1997年 | 35篇 |
1996年 | 27篇 |
1995年 | 20篇 |
1994年 | 24篇 |
1993年 | 12篇 |
1992年 | 16篇 |
1991年 | 16篇 |
1990年 | 10篇 |
1989年 | 10篇 |
1988年 | 8篇 |
1987年 | 8篇 |
1986年 | 6篇 |
1985年 | 5篇 |
1984年 | 5篇 |
1983年 | 6篇 |
1982年 | 5篇 |
1981年 | 1篇 |
1980年 | 3篇 |
1978年 | 1篇 |
1975年 | 1篇 |
排序方式: 共有3229条查询结果,搜索用时 0 毫秒
121.
122.
Chunhai Huang Xianrui Yuan Yi Wan Fei Liu Xiaoyu Chen Xianquan Zhan Xuejun Li 《International journal of clinical and experimental pathology》2014,7(3):1022-1031
This study investigated VE-statin/Egfl7 expression and its role and regulatory mechanism in malignant glioma progression. Forty-five paraffin-embedded glioma (grade I-II: n=24; grade III-IV: n=21) were examined. VE-statin/Egfl7 protein expression was detected via immunohistochemistry, and its correlation with pathological grade was evaluated. Three-dimensional cell culture was then performed to investigate the influence of VE-statin/Egfl7 on the angiogenesis of umbilical vein endothelial cells. Microarray detection was used to molecularly profile VE-statin/Egfl7 and relevant signaling pathways in malignant glioma (U251 cells). Data showed that VE-statin/Egfl7 protein was mainly expressed in the cytoplasm of cancer and vascular endothelial cells and was significantly related to the degree of malignancy (t=4.399, P<0.01). Additionally, VE-statin/Egfl7 expression was low in certain gray-matter neurons but undetectable in glial cells. VE-statin/Egfl7 gene silencing significantly inhibited angiogenesis in umbilical vein endothelial cells. The following microarray results were observed in VE-statin/Egfl7-silenced U251 cells: 1) EGFR family members showed the highest differential expression, accounting for 5.54% of differentially expressed genes; 2) cell survival-related signaling pathways changed significantly; and 3) the integrin ανβ3 signaling pathway was markedly altered. Thus, malignant glioma cells and glioma vascular endothelial cells highly express VE-statin/Egfl7, which is significantly correlated with the degree of malignancy. Moreover, VE-statin/Egfl7 plays an important role in glioma angiogenesis. Microarray results indicate that VE-statin/Egfl7 may regulate EGFR and integrins to influence the FAK activity of downstream factors, triggering the PI3K/Akt and Ras/MAPK cascades and subsequent malignant glioma development. 相似文献
123.
Sanghoon Lee M.D. Ph.D. Jae Won Kim M.D. Ph.D. Jin Hwa Hong M.D. Ph.D. Jae Yun Song M.D. Ph.D. Jae Kwan Lee M.D. Ph.D. In Sun Kim M.D. Ph.D. Nak Woo Lee M.D. Ph.D. 《Diagnostic cytopathology》2014,42(12):1058-1062
The purpose of this study was to evaluate the clinical significance of Human papillomavirus (HPV) DNA cotesting in Korean women with abnormal Papanicolaou (Pap) smear results based on colposcopic pathology. A total of 1012 women underwent liquid‐based Pap smears and hybrid capture II HPV DNA tests followed by colposcopy at the Korea University Hospital from January 2007 to May 2012. Of these women, 832 women were included in this retrospective study. The mean patient age was 45.4 ± 13.7 years (range:15–80). The distribution of Pap smear results was normal (4.7%), atypical squamous cells of uncertain significance (ASCUS) (42.1%), low‐grade squamous intraepithelial lesion (26.8%), ASC‐H (7.0%), and high‐grade squamous intraepithelial lesion (HSIL) (19.5%). In women with ASCUS, none of the 87 HPV‐negative had ≥cervical intraepithelial neoplasia (CIN2) (P < 0.001). In women with ASC‐H, only one out of 17 HPV‐negative vs. 14 out of 41 HPV‐positive had ≥CIN2 (P = 0.025). In patients with HSIL, 54.5% of HPV‐negative had ≥CIN2, as compared to 80.8% of HPV‐positive with ≥CIN2 (P = 0.039). Patients were further analyzed by age groups: <30 and ≥30 years. In HPV‐negative women, there was a significant difference in the ratio of ≥CIN2 (30.8% <30 vs. 4.5% ≥30, P = 0.005). When the HPV DNA test was negative in women ≥30, the risk of ≥CIN2 was significantly lower (P < 0.001). HPV DNA cotesting in women with ASCUS and ASC‐H furnish healthcare providers with informative data. There is a lower proportion of ≥CIN2 in HPV‐negative women and a higher proportion of ≥CIN2 in HPV‐positive. When HPV data were further evaluated by age group, the risk of ≥CIN2 was lower in HPV‐negative women, especially in women ≥30. Diagn. Cytopathol. 2014;42:1058–1062. © 2014 Wiley Periodicals, Inc. 相似文献
124.
目的 测定急性心肌梗死患者压力源性冠脉侧支血流分数(PDCF),评价PDCF与传统的Rentrop分级间的相关性。方法 29例急性心肌梗死患者行介入术,术中应用冠脉内压力导丝根据Pw/Pa计算PDCF,以0.24为PDCF截值将29例分为2组:A组(19例)PDCF〉0.24,B组(10例)PDCF≤0.24。术后根据冠脉造影行Rentrop分级。使用统计学方法对数据进行线性回归分析,讨论PDCF与Rentrop分级间的相关性。结果 Rentrop分级同PDCF呈正相关(γ=0.75,P〈0.01),但Rentrop≤1级的PDCF分布范围较为离散。结论 冠脉内压力源性PDCF测量可对AMI时侧支循环血流作出定量评价。 相似文献
125.
青岛市示范幼儿园膳食营养状况分析 总被引:1,自引:0,他引:1
目的了解青岛市示范幼儿园膳食营养状况。方法膳食调查采取称重法。结果青岛市示范幼儿园热能、锌、钙、视黄醇等营养素1999年低于标准供给量,2005年达到标准供给量。2005年与1999年相比,钙、视黄醇的幼儿园达标率从1999年8.7%和30.4%提高到2005年57.1%和71.4%。但脂肪产热占总热能比例过高、钙磷比例不适宜等问题没有明显改善。结论幼儿园膳食中应多增加含钙丰富的食物,同时控制总热能,减少脂肪摄入。 相似文献
126.
127.
目的通过分析黄芪AstragaliRadix药材的性状以及黄酮类化学成分与绝对生长年限的相关性,明确黄芪根的生长年限是引起黄芪药材性状和化学差异性的主要因素。方法收集不同产地、不同等级的黄芪药材,对其外观形态定性描述,长度、直径定量测定,并采用徒手切片法观察不同等级仿野生芪的生长年限分布,观察其分布规律。采用UPLC-UV法,色谱柱为Ultimate C18(250 mm×4.6 mm,5μm),柱温30℃,体积流量为1 mL/min,检测波长230 nm,进样量20μL,乙腈-水梯度洗脱,建立了24批不同产地黄芪药材黄酮类成分HPLC-UV指纹图谱,并对不同等级仿野生芪和栽培芪5种黄酮类成分进行含量测定。结果将不同生长方式的黄芪药材划分为仿野生芪和栽培芪2个规格。特等黄芪主要是5年以上生长年限的根段,一等主要是4~5年生的根段,二等主要是3~4年生的根段,三等主要是2~3年生的根段,四等主要是1~2年生的根段。不同产地、不同等级黄芪指纹图谱中指认出5个共有峰,采用相似度评价软件分析,以仿野生芪图谱为参照,仿野生芪样品相似度为0.892~0.994,栽培芪样品相似度为0.274~0.531,主成分分析和聚类分析均显示仿野生芪和栽培芪可以明显分成2类。仿野生芪5种黄酮类成分含量明显高于栽培芪,仿野生芪(除特等外)总黄酮含量与等级(或直径、年限)呈正相关,栽培芪与等级不相关。结论本研究为黄芪药材商品规格等级标准的制定提供科学依据,为进一步构建黄芪药材质量等级标准奠定基础。 相似文献
128.
目的 验证适应心理辅导在教学中的作用和效果。方法 队列研究方法,选择2000级的雅安市雨城区第一中学的两个高中班,入学成绩两个班基本相同(没有显著性差异)。将其中一个班进行适应心理辅导另一个班没有应用。结果 应用适应心理辅导班的高考成绩明显优于对照班。适应学习的能力明显提高。结论 适应心理辅导能够提高学生的适应能力,提高学生的学习成绩。 相似文献
129.
130.
Etleva Jorgaqi Irena Savo Andi Koraqi Xhiliola Doci Rozana Cela Ermira Vasili Mohammad Jafferany 《Dermatologic therapy》2020,33(4)
To compare results of different treatment regimens based on stratification of acne to prescribe the right treatment protocol according to clinical form and grade of acne. A transversal, cohort study conducted in 230 patients with acne vulgaris. Patients were divided into three groups according to acne severity and the results of each protocol determined in 0, 4, 6, 8, 12, 18 and 24 weeks. Statistical analysis was conducted using Wilcoxon and Mann‐Whitney tests 230 patients (99 females and 131 males) took part in the study. In first grade acne (70 patients), the most effective drug for papulo‐pustular lesions was azelaic acid, where the average value of the reduction was 1.03% per week. For comedone reduction, the most effective drug resulted retinol with 17.7% mean reduction per week. In second grade acne (66 patients), the most effective scheme was: doxycycline + topical retinoid + benzoyl peroxide. In the third grade (92 patients), the most effective drug was oral isotretinoin. Accurate stratification, based on clinical characteristics is required for better outcome. Treatment success is related to the respective individually tailored treatment schemes in patients with acne. 相似文献