全文获取类型
收费全文 | 94451篇 |
免费 | 7800篇 |
国内免费 | 5046篇 |
专业分类
耳鼻咽喉 | 2004篇 |
儿科学 | 388篇 |
妇产科学 | 2368篇 |
基础医学 | 5490篇 |
口腔科学 | 557篇 |
临床医学 | 10012篇 |
内科学 | 9559篇 |
皮肤病学 | 364篇 |
神经病学 | 1069篇 |
特种医学 | 5166篇 |
外国民族医学 | 93篇 |
外科学 | 17741篇 |
综合类 | 17417篇 |
现状与发展 | 4篇 |
预防医学 | 2511篇 |
眼科学 | 238篇 |
药学 | 4867篇 |
34篇 | |
中国医学 | 1394篇 |
肿瘤学 | 26021篇 |
出版年
2024年 | 223篇 |
2023年 | 1065篇 |
2022年 | 2236篇 |
2021年 | 2815篇 |
2020年 | 2639篇 |
2019年 | 2241篇 |
2018年 | 2049篇 |
2017年 | 2552篇 |
2016年 | 3269篇 |
2015年 | 2968篇 |
2014年 | 5447篇 |
2013年 | 5073篇 |
2012年 | 5969篇 |
2011年 | 6595篇 |
2010年 | 5635篇 |
2009年 | 5402篇 |
2008年 | 5396篇 |
2007年 | 6098篇 |
2006年 | 5572篇 |
2005年 | 5441篇 |
2004年 | 4256篇 |
2003年 | 3703篇 |
2002年 | 3243篇 |
2001年 | 3151篇 |
2000年 | 2638篇 |
1999年 | 2006篇 |
1998年 | 1738篇 |
1997年 | 1513篇 |
1996年 | 1031篇 |
1995年 | 954篇 |
1994年 | 832篇 |
1993年 | 527篇 |
1992年 | 456篇 |
1991年 | 410篇 |
1990年 | 365篇 |
1989年 | 319篇 |
1988年 | 313篇 |
1987年 | 239篇 |
1986年 | 179篇 |
1985年 | 153篇 |
1984年 | 115篇 |
1983年 | 73篇 |
1982年 | 90篇 |
1981年 | 71篇 |
1980年 | 66篇 |
1979年 | 44篇 |
1978年 | 32篇 |
1977年 | 30篇 |
1976年 | 24篇 |
1975年 | 15篇 |
排序方式: 共有10000条查询结果,搜索用时 93 毫秒
91.
Background: The bariatric patient exists in dynamic relationship with family members and friends who have considerable influence
upon the patient and his or her surgical outcome. When family members and friends behave as intimate saboteurs, they attempt
to hamper, hurt, or subvert the bariatric patient's goal of achieving and maintaining a healthy body weight. Successful or
not, intimate saboteurs provide significant treatment challenges for the patient and the treatment team. Methods and Patients:
Patient profiles provide examples of intimate sabotage. The psychological construct of Family Systems Theory is used as a
plausible explanation for the sabotage of friends and family. Conclusions: Multidisciplinary professionals treating the bariatric
patient must be aware of the critical influence of intimate saboteurs and the tactics they use to sabotage. Treatment guidelines
recommended by Family Systems Theory are presented as strategies to mitigate the influence of intimate saboteurs. 相似文献
92.
A Decade of Change in Obesity Surgery 总被引:4,自引:0,他引:4
Edward E Mason MD PhD Shenghui Tang MS Kathleen E Renquist BS Dwight T Barnes Joseph J Cullen MD Cornelius Doherty MD James W Maher MD 《Obesity surgery》1997,7(3):189-197
Background: The International (formerly National) Bariatric Surgery Registry began collecting data in January 1986. The aim
of this study was to examine changes in the practice of surgical treatment of severe obesity that occurred during the decade
of 1986 through 1995, as observed in the IBSR data. Methods: All data submitted to the IBSR during the decade were transferred
to the IBM mainframe computer for analysis. Characteristics of operative type populations were compared over time using analysis
of variance (ANOVA) for age, body mass index (BMI), operative weight and Chi-square (χ2) test for gender. Results: There has been a steady increase over the decade in mean patient weight. The operations used have
changed from predominantly ‘simple’ operations to more frequent use of ‘complex’ operations. Within the categories of ‘simple’
and ‘complex’, an increase in the variety of operations occurred. As a group, patients with ‘simple’ operations have been
heavier, more often male and public pay patients than those who have undergone ‘complex’ operations. One year weight loss
was greater for Roux-en-Y gastric bypass (RGB) than vertical banded gastroplasty (VBG), but follow-up rates were too low to
study the relative merits of the operations used. The reported incidence of operative mortality and serious complications
(leak with peritonitis, abscess and pulmonary embolism) remained low. Conclusions: These observations and their implications
can be summarized in three statements which relate to action for improved patient care in the beginning of the new century:
(1) increasing weight of candidates for surgical treatment during this decade indicates the need for earlier use of operative
treatment before irreversible complications of obesity can develop; (2) low risk of obesity surgery, decreasing postoperative
hospital stay, and early weight control support the continued and increased use of surgical treatment; (3) continued widespread
use of both ‘simple’ and ‘complex’ operations with increased modifications of standard RGB and VBG procedures emphasizes the
need for standardized long-term data and analyses regarding both weight control and postoperative side-effects. 相似文献
93.
S. Süreyya
zbek Remide Arkun Refik Killi Ayenur Memi Aynur Dadeviren Erkan Sevin 《Journal of clinical ultrasound : JCU》1995,23(4):233-238
Image-directed color Doppler ultrasonography (ICDUS) studies of 86 patients with superficial solid masses yielded significantly lower resistive index (RI) values in acute inflammatory lesions, but no significant difference between the maximum systolic flow velocities (S) of the patient groups with malignant, benign, and acute inflammatory lesions. When analyzed separately, the malignant soft-tissue tumor subgroup was shown to have significantly higher mean RI compared to that of the malignant node subgroup. We conclude that RI may be useful in the differentiation of acute inflammatory masses from other pathological entities. Malignant soft-tissue tumors, especially sarcomas, may have different Doppler features from those of carcinomatous tumors. © 1995 John Wiley & Sons, Inc. 相似文献
94.
95.
96.
[目的]观察比较异环磷酰胺(IFO)、顺铂(DDP)、5-氟尿嘧啶(5-Fu)联合方案(IPF方案)与DDP,5-Fu(PF方案)治疗晚期复发鼻咽癌(Ⅲ-Ⅳ期)的近期疗效及毒副反应。[方法]136例均经病理证实为晚期复发鼻咽癌患者,随机分为IPF组69例,PF组67例(对照组)[结果]IPF组和PF组有效率分别为69.56%(48/69)和43.3%(29/67),两组间差异有显著性(X2=8.519,P<0.01)。中位生存期:IPF组16个月(8-34个月),PF组为6.5个月(4-21个月),两组间差异有显著性(X2=22.36,P<0.05)。毒副作用主要为骨髓抑制,Ⅲ-Ⅳ度白细胞下降率IPF组为49.4%,PF组为5.97%,两组差异有显著性(X2=29.54,P<0.01)。Ⅲ-Ⅳ度血小板下降率IPF组为29.18%,PF组为0%(X2=30.29,P<0.01);Ⅲ-Ⅳ度消化道反应两组的发生率分别为15.94%和11.94%(x2=0.234,P>0.01).且以Ⅲ度为主。[结论]以IFO为主的方案联合治疗晚期复发鼻咽癌疗效好,毒副反应能耐受,可作为一线方案。 相似文献
97.
贲门癌术中留置金属导芯硅胶鼻肠管的临床研究 总被引:1,自引:0,他引:1
目的探讨贲门癌术后早期肠内营养的可行性、安全性及临床效果.方法贲门癌患者术中留置金属导芯硅胶鼻饲管,术后第1天开始肠内营养支持,术前及术后第10天,分别测量体重,检测血红蛋白浓度及肝肾功能,观察肠内营养的副作用.结果全组鼻饲管留置时间平均15.2 d;术后早期肠内营养明显增加了营养物质的摄入量,术后无明显的体重丢失,未见需要终止治疗的并发症.结论早期肠内营养治疗具有符合生理、减少医药费用等优点,该置管方法安全、简便,达到了加强术后患者营养支持的目的,可列入术后常规应用. 相似文献
98.
A case of papilliferous keratoameloblastoma is reported which is only the second ever documented. The patient was a 76-yr-old black woman with a large expansile multilocular radiolucency of the body, angle and ramus of the mandible. Histologically the lesion consisted of sheets of cystic follicles filled with necrotic debris and sometimes parakeratin. The vast majority of the follicles were lined by a papilliferous epithelium consisting of large rounded cells with centrally placed nuclei. True papillary projections with cores of connective tissue were also present. The remainder of the follicles were lined by a thin parakeratinising stratified squamous epithelium. Histological features characteristic of ameloblastoma were absent. Final classification of these lesions will have to await the reporting of further cases. 相似文献
99.
胃癌和胃癌前病变Cx43、PCNA的表达及意义 总被引:3,自引:1,他引:2
目的 通过观察间隙连接蛋白 Cx4 3和增殖细胞核抗原 (PCNA )在正常胃粘膜、胃癌前病变和胃癌中的表达和分布情况 ,探讨 Cx基因表达与胃癌发生的关系。 方法 运用 SP免疫组织化学方法检测 Cx4 3、PCNA在 70例原发性胃癌 ,6 2例中、重度不典型增生和 16例正常胃粘膜中表达规律。 结果 Cx4 3在正常胃粘膜 ,中、重度不典型增生和胃癌中表达的阳性率分别为 10 0 % ,83.9%和 17.1% ,三者比较差异有显著性 (P<0 .0 5 )。 Cx4 3表达与胃癌的分化程度相关 (P<0 .0 1)。胃癌前病变、胃癌组中的 PCNA较正常胃粘膜组增高 (P<0 .0 1)。 Cx4 3表达与 PCNA呈负相关 (P<0 .0 1)。 结论 Cx4 3表达降低在胃癌发生发展中起重要作用 ,Cx4 3可做为胃癌早期诊断的指标 相似文献
100.
长春瑞滨加异环磷酰胺加顺铂治疗晚期非小细胞肺癌98例临床疗效观察 总被引:2,自引:0,他引:2
吴海默 《中国肿瘤临床与康复》2005,12(4):338-339
目的观察长春瑞滨(NVB)、异环磷酰胺(IFO)、顺铂(PDD)三药联合(NIP)治疗晚期非小细胞肺癌的疗效和毒性.方法共收治ⅢB~Ⅳ期非小细胞肺癌98例,其中鳞癌51例,腺癌42例,大细胞癌5例.ⅢB期59例,Ⅳ期39例.初治71例,复治27例.方案:NVB 25 mg/m2静滴,第1,8天;IFO 1.5 g/m2,静滴,第1~3天;PDD 30 mg/m2,静滴,第1~3天.4周为一周期.结果 CR 1例,PR 44例,NC 45例,PD 8例,总有效率(CR PR)为45.9%.中位缓解期8个月,中位生存期11个月,1年生存率为48.0%.骨髓抑制为剂量限制性毒性,其中Ⅲ~Ⅳ度占40.8%.结论 NIP方案是治疗晚期非小细胞肺癌有效且安全的方案. 相似文献