全文获取类型
收费全文 | 305篇 |
免费 | 51篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 11篇 |
儿科学 | 7篇 |
妇产科学 | 3篇 |
基础医学 | 51篇 |
口腔科学 | 10篇 |
临床医学 | 29篇 |
内科学 | 63篇 |
皮肤病学 | 19篇 |
神经病学 | 4篇 |
特种医学 | 5篇 |
外科学 | 18篇 |
综合类 | 17篇 |
预防医学 | 1篇 |
眼科学 | 8篇 |
药学 | 1篇 |
肿瘤学 | 113篇 |
出版年
2023年 | 6篇 |
2022年 | 15篇 |
2021年 | 26篇 |
2020年 | 18篇 |
2019年 | 14篇 |
2018年 | 18篇 |
2017年 | 25篇 |
2016年 | 16篇 |
2015年 | 26篇 |
2014年 | 24篇 |
2013年 | 24篇 |
2012年 | 17篇 |
2011年 | 15篇 |
2010年 | 9篇 |
2009年 | 8篇 |
2008年 | 7篇 |
2007年 | 9篇 |
2006年 | 11篇 |
2005年 | 8篇 |
2004年 | 7篇 |
2003年 | 8篇 |
2002年 | 7篇 |
2001年 | 9篇 |
2000年 | 2篇 |
1999年 | 3篇 |
1998年 | 3篇 |
1997年 | 2篇 |
1996年 | 3篇 |
1995年 | 2篇 |
1994年 | 1篇 |
1993年 | 3篇 |
1992年 | 1篇 |
1991年 | 4篇 |
1990年 | 2篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1986年 | 2篇 |
1984年 | 1篇 |
1982年 | 1篇 |
1981年 | 1篇 |
排序方式: 共有360条查询结果,搜索用时 15 毫秒
101.
102.
《British journal of haematology》2017,177(1):72-79
Patients with primary central nervous system lymphoma (PCNSL) treated in the ‘real‐world’ setting do not represent those treated on clinical trials and might not be treated similarly. We studied characteristics and variability in care for 113 newly diagnosed PCNSL patients treated at 5 institutions in the Chicago area between 2000 and 2012. In 111 patients, single modality therapy with a high dose methotrexate (HD‐MTX) regimen +/− rituximab, was most commonly employed (n = 65), and 34 underwent radiotherapy (+/− systemic therapy). Fifty‐eight of 108 patients received rituximab. Twenty‐nine of 110 patients (26%) received intrathecal chemotherapy (ITC). Overall response rate was 80% (47% complete responses). With a median follow‐up of 18·7 months, median overall survival (OS) was 65·2 months. In univariate analysis, HD‐MTX (median OS 72·7 vs. 2·7 months, P < 0·001) and rituximab (median not reached versus 28·4 months, P = 0·005) impacted OS favourably. This significance was sustained regardless of immune status and in multivariate analysis. Whole brain radiotherapy (WBRT) resulted in a trend for improved OS as compared with systemic therapy alone (P = 0·09), while ITC did not impact survival. Clinical practice has evolved to exclude WBRT and ITC while incorporating rituximab with clinical outcomes comparable in immuno‐competent/compromised patients and similar to those achieved in recent clinical trials. 相似文献
103.
Efficacy and tolerance of GELOXD/P‐GEMOXD in newly diagnosed nasal‐type extranodal NK/T‐cell lymphoma: A multicenter retrospective study 下载免费PDF全文
104.
目的 总结鼻型结外NK/T细胞淋巴瘤18F-FDG PET/CT显像特点并探讨其诊断价值。方法 选择2013年2月至2018年6月在福建省立医院被病理确诊为鼻型结外NK/T细胞淋巴瘤并行18F-FDG PET/CT检查的17例患者,其中男11例,女6例,年龄25~79岁;9例为术后确诊为鼻型结外NK/T细胞淋巴瘤化疗前PET/CT检查;其中有7例患者治疗后加行1次PET/CT检查评价疗效。釆用SPSS17. 0软件进行统计学分析。结果 (1)鼻部病灶累及情况:累及鼻腔、鼻中隔9例,鼻腔及邻近鼻窦6例,累及鼻腔、鼻背部皮下软组织和颌面部2例。(2)合并鼻外其他部位淋巴瘤浸润4例:左侧鼻咽部、双侧颈部淋巴结浸润1例,左乳、心包、肝脏、脾脏、骨骼、全身皮下、胸膜、腹膜多发浸润1例,鼻咽部、口咽部、全身淋巴结、胸腺区、胃壁、阴茎海绵体多发浸润1例,双侧肾上腺、睾丸1例。(3)鼻部病灶SUVmax情况:SUVmax 5.0~25.9(14.06±5.94);鼻外淋巴瘤浸润病灶SUVmax 8.0~24.9(12.88±7.05)。(4)9例术后患者均发现淋巴瘤残留病灶,1例发现其他部位淋巴瘤浸润。(5)7例化疗后复查,完全缓解4例,部分缓解2例,复发1例。结论 鼻型结外NK/T细胞淋巴瘤以鼻型为主,病灶常范围较广,可累及鼻翼、邻近皮肤及鼻外脏器,18F-FDG PET/CT显像具有较高的诊断价值。 相似文献
105.
106.
Primary bladder lymphoma: management and outcome of 12 patients with a review of the literature 总被引:1,自引:0,他引:1
Primary bladder non-Hodgkin's lymphoma (NHL) is rare. Optimal management remains controversial. Using the Scotland and Newcastle lymphoma group database, 12 patients with primary bladder lymphoma were identified between 1980 and 2001, the largest single group of patients available to date. Histology and immunocytochemistry was reviewed in 9 of the 12 cases. Six cases were low-grade extranodal marginal zone lymphoma, 4 diffuse large B-cell lymphoma, one an ALK 1 positive anaplastic large cell lymphoma (ALKoma) and one a low-grade lymphoma unspecified. Two patients (low-grade NHL) were treated with oral antibiotics (n = 1) or diathermy (n = 1) alone with complete resolution of disease. One patient with high-grade NHL gained complete remission without conventional therapy. Nine patients were treated with single or combined modality surgery, chemotherapy and/or radiotherapy. Overall survival was 75%, mean follow up of 4.8 (range 1 - 10) years. A review of 88 additional cases in the literature support the findings that primary bladder lymphoma is associated with a good prognosis. Patients with low-grade extranodal marginal zone lymphoma may respond well to simple therapies. Patients with diffuse large B-cell lymphoma respond well to first-line chemotherapy regimens. Ureteric obstruction and acute renal failure are serious complications. Repeat cystoscopy is mandatory for follow-up. 相似文献
107.
30年恶性淋巴瘤的自然检出率分析 总被引:1,自引:0,他引:1
本文报告了我院30年间经活检证实的 1332例恶性淋巴瘤,其中男性占70%,女性29%;年龄最大 83岁,最小20个月。HD 305例,NHL 972例,不能分类者 55例。ML在我省 60、70、80年代间的增长速度是 3倍和 1.5焙,发病年龄高峰也早于国内大宗报道的 10年,而且结外ML的比例偏高。 相似文献
108.
109.
110.