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31.
《Mayo Clinic proceedings. Mayo Clinic》2021,96(9):2407-2417
ObjectiveTo evaluate the effectiveness and adverse events of autologous platelet-rich plasma (PRP) in individuals with lower-extremity diabetic ulcers, lower-extremity venous ulcers, and pressure ulcers.Patients and MethodsWe searched multiple databases from database inception to June 11, 2020, for randomized controlled trials and observational studies that compared PRP to any other wound care without PRP in adults with lower-extremity diabetic ulcers, lower-extremity venous ulcers, and pressure ulcers.ResultsWe included 20 randomized controlled trials and five observational studies. Compared with management without PRP, PRP therapy significantly increased complete wound closure in lower-extremity diabetic ulcers (relative risk, 1.20; 95% CI, 1.09 to 1.32, moderate strength of evidence [SOE]), shortened time to complete wound closure, and reduced wound area and depth (low SOE). No significant changes were found in terms of wound infection, amputation, wound recurrence, or hospitalization. In patients with lower-extremity venous ulcers or pressure ulcers, the SOE was insufficient to estimate an effect on critical outcomes, such as complete wound closure or time to complete wound closure. There was no statistically significant difference in adverse events.ConclusionAutologous PRP may increase complete wound closure, shorten healing time, and reduce wound size in individuals with lower-extremity diabetic ulcers. The evidence is insufficient to estimate an effect on wound healing in individuals with lower-extremity venous ulcers or pressure ulcers.Trial RegistrationPROSPERO Identifier: CRD42020172817 相似文献
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Elliot L. Jurist 《Clinical psychology》2013,20(2):221-223
This commentary offers a challenge to Norcross and Karpiak's (2012) claim that the psychodynamic orientation is on the decline in clinical psychology, based upon the data that they present. I urge clinical psychologists/scientists to recognize that there are psychodynamic researchers who have embraced evidence‐based philosophy and practices; I advocate a rapprochement between Division 12 (Society of Clinical Psychology) and 39 (Psychoanalysis), and I propose a defense of pluralism in which all clinical psychologists recognize the obligation to engage other orientations and points of view that differ from their own and to do so respectfully. 相似文献
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Objective: We investigated the application of 51 autosomal short tandem repeat (STR) loci with the identity by state (IBS) method and a discriminant function algorithm in full-sib identification. Methods: A total of 342 pairs of full sibs (FSs) and 3900 pairs of unrelated individuals (UIs) were genotyped for 51 STR loci. Groups were formed in accordance with discrimination power (DP) values and the number of loci, and IBS scores of FSs and UIs were analyzed and compared. The discriminant functions of FS-UI were determined by using the Fisher discriminant with SPSS software. Results: All IBS in FSs and UIs groups showed normal distributions and there were significant differences between FS-UI. Receiver operating characteristic curves revealed that the detection efficiency of full-sib identification was affected by both the locus polymorphism and the number of loci detected. Comparing the rate of false positive and false negative of discriminant function between groups, a higher average DP value and larger number of loci detected were associated with a lower rate of miscarriage of justice and were more helpful for full-sib identification. Conclusion: STRs with higher DP values should be selected when additional autosomal markers are required for FS identification. Discriminant analysis with the IBS method is highly applicable for the FS-UI test. 相似文献
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The impact of research education on student nurse attitude,skill and uptake of evidence‐based practice: a descriptive longitudinal survey 下载免费PDF全文
Matthew J Leach RN BN ND DipClinNutr PhD Anne Hofmeyer RN DipUnivTeach MPHC PhD Amanda Bobridge RN BN BHSc PhD 《Journal of clinical nursing》2016,25(1-2):194-203
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作者通过对一起由医疗纠纷引起的吊销《医疗机构执业许可证》行政处罚案例的分析,指出医疗卫生执法监督员面临棘手的医疗纠纷案件时,既需要善于学习和运用医疗专业知识,又需要善于应用行政证据规则,合理、有效地收集和运用证据,最终成功办案,维护社会公平。 相似文献