流感疫苗壳聚糖脂质体的制备工艺

目的在流感疫苗脂质体的基础上制备壳聚糖脂质体载药微粒,建立流感疫苗壳聚糖脂质体的制备工艺．方法采用薄膜分散法制备流感疫苗脂质体,以不同N/P比（壳聚糖中的氮和卵磷脂中的磷比值）制备壳聚糖载药微粒．观察形态并测定其平均粒径、粒度分布、包封率与结合率．通过对比不同N/P比制备壳聚糖载药微粒的包封率与结合率等指标,确定流感疫苗壳聚糖脂质体的制备工艺．结果流感疫苗脂质体形态均呈圆或椭圆形,粒度分布较均匀,壳聚糖包覆后脂质体仍为圆形,平均粒径由2．14μm增加到4．05μm．壳聚糖包覆前后流感疫苗脂质体平均包封率由80．41％变为84．37％．比较6种不同N/P比流感疫苗壳聚糖脂质体的结合率,当N/P为5：1时,为壳聚糖与脂质体孵育的最佳比例,结合率为19．40％．结论壳聚糖包覆后脂质体仍接近圆形,粒径增加,包封率提高,当N/P为5：1时,为壳聚糖与脂质体孵育的最佳比例．     

消毒供应社会化的成本效益分析

目的提高消毒灭菌质量,降低消毒费用。方法将医院消毒物品供应工作委托给具有合格资质的深圳市福田消毒供应中心,并对消毒供应中心和医院消毒供应室灭菌物品检测结果,两种消毒供应室成本核算,科室对中心的投诉情况,进行客观评定。结果两种消毒供应室灭菌物品检测结果分别经2χ检验,灭菌物品清洗有显著性差异,P<0.05;灭菌物品灭菌无显著性差异,P>0.05。消毒供应中心灭菌物品灭菌效果达到消毒技术规范标准。两种消毒供应室1年内消毒灭菌成本核算经t检验,有显著性差异,P<0.001。消毒供应中心成本核算比医院供应室减少。1年内各科对消毒供应中心投诉15次。结论消毒供应社会化确保消毒灭菌质量,降低消毒成本,满足医院对消毒灭菌物品的供应,方便医院管理,值得推广。     

综合医院超声检查患者服务系统合理性研究

目的 分析超声检查服务系统的运行规律,为超声检查资源的优化配置提供科学依据。方法 采用排队论的理论与方法,随机测量某三级综合医院的超声检查服务时间及患者到达时间,计算服务强度等运行指标。结果 当前超声检查上午的服务强度过高（〉110%）,下午各队列的服务强度在77%～85%,服务流程不合理。通过改变预约模式,可有效地提高系统的运行效率。结论 应用排队论的理论与方法评价超声检查服务流程效率合理可行,值得推广。     

政府保障公平市场提高效率——社会主义市场经济规律下的医改路径分析

中国已实现了由计划经济向市场经济的转型,在社会主义市场经济的大背景下,医药卫生行业必须遵循客观经济规律,政府和市场的两只手互为补充、互相协作,政府保障公平,市场发挥效率,共同推进医药卫生体制改革.     

基于麦肯锡7S模型的医疗耗材规范化管理的探讨与应用

目的 根据新形势下对医疗耗材规范化管理的要求,探讨麦肯锡7S模型在医院医疗耗材规范化管理中的应用,为提高医疗耗材管理效率提供探讨依据.方法 通过将麦肯锡7S模型与实际情况结合,优化原有医疗耗材管理流程,并对比麦肯锡7S模型实施前后医疗耗材品项管理情况、耗材配送效率等对医疗耗材规范化管理效果进行评价.结果 2017年以来...     

分级诊疗视域下广东省基层卫生资源配置效率分析

目的 通过对2013-2018年广东省基层医疗机构及2018年各地级市乡镇卫生院的卫生资源配置效率的评估,为广东省基层医疗机构优化资源配置,及各地级市合理推进分级诊疗制度提供参考.方法 采用Malmquist模型测算2013-2018年广东省基层医疗卫生资源整体配置效率;利用CRS-CCR和VRS-BCC模型评估各地级...     

细粒棘球绦虫重组BCG-Eg95疫苗的构建及其表达效率研究

目的 构建细粒棘球绦虫重组BCG-Eg95疫苗,分析Eg95分子在该疫苗中的表达效率.方法超声粉碎细粒棘球蚴组织提取总RNA,通过RT-PCR扩增Eg95的抗原编码基因;将该基因定向克隆到大肠杆菌-分枝杆菌穿梭表达载体pB-CG,构建重组质粒pBCG-Eg95;电穿孔法转化BCG,构建细粒棘球绦虫重组BCG-Eg95疫苗.免疫印迹分析重组BCG-Eg95疫苗的表达产物.结果 RT-PCR成功扩增出471 bp的Eg95抗原编码基因;双酶切证实Eg95抗原编码基因成功插入pBCG中;PCR证实rBCG-Eg95疫苗构建成功;免疫印迹分析发现重组BCG-Eg95疫苗的表达产物在相对分子质量(Mr)约为16.5×103处有明显的目的 蛋白表达条带,且能被感染细粒棘球蚴的鼠血清特异识别.结论 成功构建了细粒棘球绦虫重组BCG-Eg95疫苗,为而后的开发利用奠定了理论基础.     

The Technical Efficiency of Hospitals under a Single Payer System: The Case of Ontario Community Hospitals

Using DEA, we investigated the impact of ownership, size, and location on the relative technical efficiency of community hospitals in Ontario, which has a single payer system. Consistent with Hansmann's theory of non-profit organizations and contrary to US-based research, we find no significant differences in efficiency across ownership types (government, religious or secular non-profit). Nor do we find significant differences in efficiency by size or location. Our findings suggest that model formulation and differences in payer mix across types of hospitals in the US have a strong influence on the measurement of the hospital ownership–efficiency relationship.     

污染土壤电动修复正交试验研究

通过正交试验研究了电动修复Cr6 污染高岭土过程中施加电压、处理时间、含水率、阴极电解产生OH一控制4个因素对污染物去除率和电能消耗的影响.试验选用重铬酸钾作为污染物,配制高岭土中Cr6 初始含量为500mg·kg-1.试验结果表明:阴极pH控制对cr6 去除率影响最大,其次为施加电压和处理时间,含水率影响最小;电压对电能消耗的影响最大,其次为时间和含水率,阴极pH控制对电能消耗影响最小.分析表明控制阴极pH是提高污染土壤电动修复效率的优先选择.     

Analysis of Mechanical Properties Related to Fiber Length of Closed-Loop-Recycled Offcuts of a Thermoplastic Fiber Composites (Organo Sheets)

Increasing demand for energy-efficient means of transport has steadily intensified the trend towards lightweight components. Thermoplastic glass fiber composites (organo sheets) play a major role in the production of functional automotive components. Organo sheets are cut, shaped and functionalized by injection molding to produce hybrid components, such as those used in car door modules. The cutting process produces a considerable amount of production waste, which has thus far been thermally recycled. This study develops a closed mechanical recycling process and analyzes the different steps of the process. The offcuts were shredded using two shredding methods and implemented directly in the injection-molding process. Using tensile tests and impact bending tests, the material properties of the recycled materials were compared with the virgin material. In addition, fiber length degradation via the injection-molding process and the influence of the waterjet-cutting process on the mechanical properties are investigated. Recycled offcuts are both comparable to new material in terms of mechanical properties and usability, and are also economically and ecologically advantageous. Recycling polypropylene waste with glass fiber reinforcement in a closed loop is an effective way to reduce industrial waste in a sustainable and economical production process.