Dermatotoxicologic clinical solutions: clinical management of fragrance mix #1 #2 patients?

Today’s fragrances are present in more than just perfumes, having become ubiquitous in skin care products such as creams, shampoos, sun tan lotion and deodorants. While aromatics can arouse the senses, aromatic compounds applied to skin can also cause allergic contact dermatitis. This article describes diagnosis, limitations of patch testing for fragrance mix 1 and fragrance mix 2, the relevance of fragrance concentration in products, use testing of common consumer products and our current recommendations in regards to the management of fragrance contact allergy.     

Disruption of Limbic Pathways in a Case of Profound Amnesia

We report a case of episodic amnesia in which the anatomical basis of injury was investigated by diffusion tensor imaging (DTI). Two months after an adult male suffered severe closed head injury, conventional magnetic resonance imaging (CMRI) revealed only a right superior frontal lesion. However, 14 years later, DTI revealed structural anomalies not visible on CMRI involving limbic white matter tracts, notably the fornix, which could explain the amnesia.     

The Synergistic Effect of Polyphosphates Acid and Different Compounds of Waste Cooking Oil on Conventional and Rheological Properties of Modified Bitumen

In order to conserve non-renewable natural resources, waste cooking oil (WCO) in bitumen can help lower CO₂ emissions and advance the environmental economy. In this study, three different components of WCO were isolated and then, together with polyphosphoric acid (PPA), used separately as bitumen modifiers to determine the suitability of various substances in WCO with PPA. Conventional tests, including penetration, softening point temperature, and ductility, and the dynamic shear rheology (DSR) test, including temperature sweep and frequency sweep, were used to evaluate the influence of WCO/PPA on the traditional performance and rheological properties at high and low temperatures. The results indicate that WCO reduced the ductility and penetration value, when the use of PPA increased the softening point temperature and high-temperature performance. Compared to reference bitumen, the rutting factor and viscous activation energy (Ea) of bitumen modified with 4% WCO and 2% PPA has the most significant increase by 18.6% and 31.5, respectively. All components of WCO have a significant impact on improving the low-temperature performance of PPA-modified bitumen. The performance of the composite-modified bitumen at low temperatures is negatively affected by some waxy compounds in WCO, such as methyl palmitate, which tends to undergo a solid–liquid phase change as the temperature decreases. In conclusion, the inclusion of WCO/PPA in bitumen offers a fresh approach to developing sustainable pavement materials.     

Carboxyl-Terminal Decoy Epitopes in the Capsid Protein of Porcine Circovirus Type 2 Are Immunogenicity-Enhancers That Elicit Predominantly Specific Antibodies in Non-Vaccinated Pigs

In the context of the carboxyl-terminus (C-terminus) of the capsid protein of porcine circovirus type 2a (PCV2a) and PCV2a vaccines, this study aimed to explore its unrevealing cryptic epitope and its relation to PCV2-infected herd immunity. To discover the C-terminus of the capsid protein of PCV2a, monoclonal antibodies (mAbs) were generated in this work. Two mAbs bound the two minimal linear epitopes (₂₂₉PPLKP₂₃₃ and ₂₂₈DPPLNP₂₃₃ (or ₂₂₉PPLNP₂₃₃)), which were located at the C-terminus of the capsid proteins of PCV2a and PCV2b, respectively. One mAb bound to the minimal linear epitope (₂₂₀QFREFNLK₂₂₇, peptide P82), but it neither bound the virus-like particle (VLP) of PCV2a nor produced positive staining in PCV2a-infected cells by immunofluorescence assay. Further, the residues 220–227 were not accessible on the surface of the VLP on the three-dimensional model, but the residues 228–231 extend toward the VLP exterior. Immunoassays were conducted in this study to screen anti-viral peptide-specific IgGs, which could differentiate vaccinated pigs from non-vaccinated ones. The data show two ₂₂₀QFREFNLKDPPLKP₂₃₃-containing peptides had a significantly higher binding reactivity with sera from PCV2-infected pigs in the control group than with sera from the VLP-vaccine group, particularly seen in sera from swine aged 15 weeks to 24 weeks. However, the peptide P82 had not this phenomenon in that test. This study confirmed that C-terminal epitopes play an important role in PCV2-induced decoy of swine humoral immunity.     

内外侧双钢板内固定手术治疗复杂肱骨远端骨折的临床疗效

目的探讨内外侧双钢板内固定手术治疗复杂肱骨远端骨折的临床疗效。方法收集2009年1月~2014年1月我院收治18例C型肱骨远端骨折患者进行回顾性分析,按照AO骨折分型,其中C1型7例,C2型5例,C3型6例;18例患者均采用肱骨远端内外侧联合入路手术并均用内外侧解剖锁定钢板进行内固定治疗,术后指导功能锻炼并定期随访,采用Cassebaum方法评价其临床疗效。结果18例均采用内外侧解剖锁定钢板内固定方式完成手术,均获得定期随访12~48（18±1.1）个月。患者骨折全部愈合,无感染、骨不连或创伤性关节炎情况发生;随访采用Cassebaum方法评定术后肘关节功能,其中优13例,良3例,可2例,优良率为89.0%。结论内外侧双钢板内固定手术治疗复杂肱骨远端骨折具有较好临床疗效,是治疗复杂肱骨远端骨折的最有效方法之一,应该得到更深入的研究与推广。      

甲状腺次全切术治疗双侧结节性甲状腺肿的疗效

目的 研究双侧结节性甲状腺肿(nodular goiter,NG)患者行甲状腺全切术、甲状腺次全切术的治疗效果.方法 样本采集2014年1月—2020年3月本院收治的100例双侧NG患者,随机分对照组(甲状腺全切术)与观察组(甲状腺次全切术)各50例,比较两组手术效果、甲状腺功能指标及并发症发生情况.结果 两组术中出血...     

胫骨内侧钢板固定治疗小腿骨折的疗效及影响

目的 探讨胫骨内侧钢板固定治疗小腿骨折对功能恢复及并发症发生率的影响效果.方法 选取2019年1月—2020年1月本院收治的小腿骨折患者90例,随机分为两组,每组45例,对照组应用常规钢板固定治疗,研究组应用胫骨内侧钢板固定治疗,对两组患者的治疗效果、膝关节功能恢复情况以及并发症的发生率进行比较.结果 研究组患者治疗总...