全文获取类型
收费全文 | 20880篇 |
免费 | 1446篇 |
国内免费 | 506篇 |
专业分类
耳鼻咽喉 | 530篇 |
儿科学 | 476篇 |
妇产科学 | 1221篇 |
基础医学 | 506篇 |
口腔科学 | 525篇 |
临床医学 | 2115篇 |
内科学 | 3594篇 |
皮肤病学 | 129篇 |
神经病学 | 555篇 |
特种医学 | 472篇 |
外国民族医学 | 2篇 |
外科学 | 7102篇 |
综合类 | 2147篇 |
现状与发展 | 2篇 |
预防医学 | 793篇 |
眼科学 | 739篇 |
药学 | 763篇 |
87篇 | |
中国医学 | 304篇 |
肿瘤学 | 770篇 |
出版年
2024年 | 63篇 |
2023年 | 470篇 |
2022年 | 743篇 |
2021年 | 1074篇 |
2020年 | 1066篇 |
2019年 | 880篇 |
2018年 | 848篇 |
2017年 | 766篇 |
2016年 | 714篇 |
2015年 | 731篇 |
2014年 | 1361篇 |
2013年 | 1389篇 |
2012年 | 985篇 |
2011年 | 1126篇 |
2010年 | 978篇 |
2009年 | 927篇 |
2008年 | 959篇 |
2007年 | 928篇 |
2006年 | 866篇 |
2005年 | 777篇 |
2004年 | 695篇 |
2003年 | 635篇 |
2002年 | 483篇 |
2001年 | 467篇 |
2000年 | 302篇 |
1999年 | 274篇 |
1998年 | 255篇 |
1997年 | 235篇 |
1996年 | 194篇 |
1995年 | 151篇 |
1994年 | 165篇 |
1993年 | 151篇 |
1992年 | 149篇 |
1991年 | 119篇 |
1990年 | 93篇 |
1989年 | 91篇 |
1988年 | 95篇 |
1987年 | 73篇 |
1986年 | 51篇 |
1985年 | 91篇 |
1984年 | 80篇 |
1983年 | 46篇 |
1982年 | 61篇 |
1981年 | 58篇 |
1980年 | 39篇 |
1979年 | 35篇 |
1978年 | 27篇 |
1977年 | 25篇 |
1976年 | 12篇 |
1975年 | 15篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
61.
妊娠合并急性阑尾炎的临床特点 总被引:1,自引:0,他引:1
报告妊娠期急性阑尾炎31例,占急性阑尾炎的063%,占女性急性阑尾炎的156%。手术治疗58%。阑尾穿孔226%,其中完全流产、先兆流产、低位肠瘘各32%。本病特点为:早期:症状、体征与一般病人相似,但恶心、呕吐易被误认为是妊娠反应;中期:疼痛和压痛部位向上向内移位;晚期:腹痛和压痛位于右上腹或右侧腹部,易被误认为子宫收缩痛。本病炎症容易播散,可发生早产、流产或孕妇死亡。应早期确诊,及时手术。 相似文献
62.
Identifying patients at risk for,and treatment of major psychiatric complications of cancer 总被引:3,自引:0,他引:3
William Breitbart 《Supportive care in cancer》1995,3(1):45-60
A critically important aspect of supportive care in cancer is the prompt recognition and effective treatment of psychiatric complications. Psychiatric disorders such as depression, anxiety and delirium occur in a signifcant percentage of cancer patients, particularly as disease advances and as cancer treatments become more aggressive. This paper reviews factors that can be utilized to identify patients who are at increased risk for developing psychiatric complications, such as those with advanced disease, certain cancer treatments, uncontrolled physical symptoms, functional limitations, lack of social support, and past history of psychiatric disorder. Methods of diagnostic assessment and strategies for managing depression, anxiety, delirium and suicidal ideation are also reviewed.Presented as an invited lecture at the 6th International Symposium: Supportive Care in Cancer, New Orleans, La., USA, 2–5 March 1994 相似文献
63.
Summary One hundred patients with a verified subarachnoid haemorrhage were studied in a double blind, placebo-controlled trial at a single centre to determine the value and relative risks of tranexamic acid (TXA) in the management of ruptured intracranial aneurysms. The incidence of recurrent haemorrhage between active and placebo groups was identical (12%) and the mortality from recurrent haemorrhage was 7% and 5%, respectively. The overall incidence of cerebral infarction before surgery, at discharge and at 6 months follow-up was greater in the TXA group (27%) than in the control group (11%). Post-operative cerebral ischaemia was significantly more frequent in the active, 18 of 29 as compared to 6 of 32 patients, in the placebo group. In a fifth of the patients in whom cerebral blood flow was estimated there was a significant reduction of cerebral blood flow (CBF) on the side of the ruptured aneurysm in the TXA treated group. It is suggested that this may be the cause of the increased incidence of cerebral ischaemia in this group. There was no significant difference in the incidence of cerebral vasospasm, hydrocephalus, visual disturbances and gastrointestinal disturbances.More fatalities were encountered from ischaemia and recurrent haemorrhage in the TXA group but these differences did not reach statistical significance at the 5% level. Given that disability was due to either vasospasm or recurrent haemorrhage then a patient under TXA treatment was significantly more likely to have disability due to vasospasm (p<0.04); the reverse was true for the placebo patient (p<0.05). 相似文献
64.
D. A. Haskins J. S. Jahr M.D. M. Texidor U. Ramadhyani 《Acta anaesthesiologica Scandinavica》1992,36(6):513-515
Omeprazole is a substituted benzimidazole that causes dose-dependent intracellular inhibition of gastric acid secretion in humans. This double-blind study examined the effect of omeprazole in decreasing gastric acidity and gastric residual volume in outpatient adults. Unpremedicated outpatients, ASA I-III, 18 years or older (n = 17), were randomly assigned to receive omeprazole 80 mg, or placebo by mouth the night before scheduled elective outpatient surgery. The patients were fasted for 8 h prior to surgery. After the patient was anesthetized, an orogastric tube was inserted with proper placement verified by auscultation for gastric sounds. Gastric residual contents were withdrawn into a Luken's trap, and pH was then determined and gastric volume indexed to weight (ml.kg-1). Data were analyzed by a t-test, with P less than 0.05 considered statistically significant. Patient characteristics of both groups were similar. There was a statistically significant difference between the two groups for pH (P = 0.02), but not between the two groups for gastric volume indexed to weight (P = 0.07). 相似文献
65.
P.G. McNally N.T. Raymond P.G.F. Swift J.R. Hearnshaw A.C. Burden 《Diabetic medicine》1993,10(10):906-908
This study investigated the relationship between the development of diabetic retinopathy and pubertal status at onset of diabetes in 521 Type 1 diabetic patients diagnosed between 1950 and 1985. Pubertal status was based on age at onset (girls ≧ 11 years and boys ≧ 12 years). Retinopathy (all forms) developed in 112 patients (21.5%; 65 background and 47 proliferative retinopathy). For subjects diagnosed in either the prepubertal or postpuberal period, a similar proportion survived without developing retinopathy for any given duration of diabetes (X2 = 0.3822, p = 0.54). However, if only the postpubertal duration of diabetes is considered, then the proportion of patients surviving without retinopathy was significantly less for those diagnosed in the prepubertal period (X2 = 14.2, p = 0.002). This study suggests that the prepubertal duration of diabetes is an important phase and that the years prior to puberty do contribute to the risk of developing microvascular injury. 相似文献
66.
妇科恶性肿瘤术后骨质疏松症的防治 总被引:1,自引:0,他引:1
为探讨妇科恶性肿瘤术后骨质疏松症的预防措施,采用补充紫竹爱维和乐力胶囊来预防骨质疏松的发生,分别与未服药的妇科恶性肿瘤及良性肿瘤术后作对照,并对其对骨代谢指标血清骨性碱性磷酸酶(BALP)及血清抗酒石酸酸性磷酸酶(TRAP)的影响进行了临床观察.结果发现恶性肿瘤术后较良性肿瘤术后患者的BALP降低,TRAP增高,服用紫竹爱维与乐力胶囊的患者TRAP均低于未服药的恶性肿瘤术后患者,P<0.05,均有显著性差异.表明妇科恶性肿瘤术后患者较良性肿瘤更易患骨质疏松症,服用紫竹爱维与乐力胶囊均能有效防治骨质疏松症,前者效果更佳,但应掌握性激素补充治疗(HRT)的应用指征. 相似文献
67.
R. Grundmann U. Szillat 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》1989,374(2):84-91
Zusammenfassung Über ein Jahr wurden 1082 allgemeinchirurgische Planeingriffe prospektiv konsekutiv erfaßt und ihre Komplikationen mit einem Score bewertet. EinflußgröBen und die Komplikationsraten, die unter Umständen von der Kliniks-organisation abhängig sind, sollten analysiert werden. Es fand sich eine Beziehung zwischen Komplikationen und Wochentag, Operationsdauer sowie der Abweichung der tatsächlich benötigten von der geplanten Operationszeit. Mit höherer Auslastung der Operationssäle pro Arbeitstag stiegen die Komplikationsraten ebenfalls an.Keinen Einfluß auf die Komplikationsraten hatten Operationsbeginn und-monat sowie die monatliche Auslastung der Säle. Ob das Wetter einen Einfluß auf die Komplikationsraten nahm, konnte nicht entschieden werden: so fanden sich im Sommer- höhere Komplikationsraten als im Winterhalbjahr, jedoch war der Score von der Höhe der Außentemperatur und der Luftfeuchtigkeit unabhängig.
The influence of time of operation and hospital organization on postoperative complication rates
Summary During a 1-year period 1082 general surgical interventions were prospectively documented and their complication rates evaluated by a score system. Factors responsible for the complication rates and possibly depending on hospital organization should be analysed. The complication rates were influenced by the selection of the weekday, the length of operation time and the extent of discrepancy between planned and required operation time. Furthermore, the complication rates paralleled the extent of utilization of the operation theatre during a workday. The complication rates werenot affected by the beginning of operation and the operation month as well as the monthly utilization of the operation theatres. Whether the weather did influence the complication rates could not be decided: higher complication rates were found in the summer as compared to the winter period, but the complication score was independent of the level of the outside temperature and humidity.相似文献
68.
目的 :评价原发性肝癌并发门静脉高压症的外科治疗效果。方法 :回顾性分析联合手术治疗原发性肝癌并发门静脉高压症 30例的疗效。结果 :手术死亡 1例 ,严重肺部感染、肝肾综合征及顽固性腹水各 1例。术后 1、3、5年生存率分别为 93.3%、5 3.3%、40 %。随访中共死亡 1 7例 ,死亡原因 :肝癌复发 9例 ,肝功能衰竭 5例 ,上消化道出血 3例。结论 :理性选择联合手术方式治疗原发性肝癌并发门静脉高压症是安全可行的 ,联合行胃冠状静脉栓塞和脾切除术效果良好。 相似文献
69.
妊娠期妇女外阴阴道念珠菌病的病原学和治疗研究 总被引:15,自引:0,他引:15
目的 调查孕妇外阴阴道念珠菌病(vulvovaginal candidiasis,VVC)的发病率,对检出的VVC进行病原学和治疗研究。方法 连续对产科门诊1000例孕妇进行VVC发病情况调查。对分离的念珠菌进行体外抗真菌药物敏感试验。对66例VVC患者应用咪康唑栓治疗,400mg/d,6d为一疗程。结果 孕妇VVC的发病率为12.7%(127/1000)。37.4%(374/1000)的孕妇以往有VVC病史,0.6%的孕妇为复发性VVc。127例VVC中,白念珠菌、光滑念珠菌、热带念珠菌和克柔念珠菌分别占87.1%、9.9%、1.5%和1.5%。有4例患者同时感染2种念珠菌。114株白念珠菌对咪康唑、克霉唑、氟康唑、伊曲康唑、制霉菌素耐药率依次为10.5%、2.6%、6.1%、7.9%和0。13株光滑念珠菌对咪康唑和制霉菌素均敏感,对克霉唑、伊曲康唑和氟康唑均敏感或剂量依赖敏感。应用咪康唑栓治疗的患者在治疗完成后1~2周及4~6周的病原学治愈率分别为84.8%和80.3%。结论 VVC是孕妇的常见病,白念珠菌仍然是主要致病菌,其次为光滑念珠菌。常用抗真菌药物对引起VVC的念珠菌存在不同程度的耐药率,应用咪康唑栓治疗孕妇VVC效果满意。 相似文献
70.
Retrospective review of the preoperative biliary and gastrointestinal evaluation for gastric bypass surgery 总被引:1,自引:0,他引:1
Vincent W. Vanek M.D. C.N.S.P. F.A.C.S. Michele Catania R.N. B.S.N. Kimberly Triveri R.D. L.D. Robert W. Woodruff Jr M.D. 《Surgery for obesity and related diseases》2006,2(1):839-22
BACKGROUND: The purpose of this study was to analyze the frequency and results of preoperative biliary and gastrointestinal (GI) evaluation of patients undergoing Roux-en-Y gastric bypass (RYGB). METHODS: Retrospective review of the preoperative evaluation of 144 consecutive RYGB patients. RESULTS: Cholecystectomy had already been performed in 43 (30%) patients; 22% of those patients with an intact gallbladder had cholelithiasis. Ten patients (7%) had an upper GI x-ray (UGI), and 94 patients (65%) had an esophagogastroduodenoscopy (EGD). Abnormalities were found in 40% of the UGIs and 84% of the EGDs. A total of 96 patients (67%) were tested for Helicobacter pylori; 11% were positive. Twenty-one patients (15%) underwent preoperative colonoscopy; 48% were abnormal, but most of the abnormalities were not clinically significant. Three patients had barium enema x-ray, which was normal in all cases. CONCLUSIONS: The preoperative biliary and GI evaluation of bariatric surgery patients should include a routine ultrasound of the gallbladder. Routine preoperative EGD will detect a significant number of abnormalities that should be treated, but should rarely alter the bariatric surgical procedure or result in denial of bariatric surgery. Many abnormalities will be asymptomatic. Patients should be routinely screened for H. pylori and, if positive, treated before bariatric surgery. Lower GI evaluation should be performed selectively based on the patient's symptoms, physical findings, and guidelines for colorectal cancer and polyp screening. 相似文献