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61.
M. Fujioka M.D. K. Okuchi S. Miyamoto T. Sakaki S. Tsunoda S. Iwasaki 《Acta neurochirurgica》1994,131(3-4):265-269
Summary The authors describe a 66-year-old man with progressive gait disturbance caused by bilateral organized chronic subdural haematomas. The characteristics of these lesions on magnetic resonance (MR) images have not yet been clarified. The organized haematoma in our patient exhibited slight hypo-intensity on T 1-weighted MR images and marked hypo-intensity on T 2-weighted MR images obtained at 1.5 T. Preoperative MR imaging may give us useful information about surgical strategy in the case of chronic subdural haematoma with an unusual appearance on computed tomographic (CT) scans. 相似文献
62.
63.
人工肾的最新进展及临床应用 总被引:7,自引:0,他引:7
本介绍了人工肾的发展史、临床应用、选购和发展趋势。指出:随着高新技术和透析原理的发展,目前已从血液透析演变为血液净化,拓宽了其临床应用范围。采用组织工程、基因、细胞技术研制的生物人工肾,可望生产出易携带或可移植的生物人工肾,可完全替代肾功能,减少肾衰竭病人的死亡率,成为代肾发展史上的又一个里程碑。 相似文献
64.
The ionic mechanisms of the effect of extracellularly ejected recombinant human tumor necrosis factor-alpha (rhTNF-alpha) on the membrane of identified neurons R9 and R10 of Aplysia kurodai was investigated with conventional voltage-clamp, micropressure ejection, and ion substitution techniques. Micropressure-ejected rhTNF caused a marked hyperpolarization in the unclamped neuron. Clamping the same neuron at it resting potential level (-60 mV) and reejecting rhTNF-alpha with the same dose produced a slow outward current [Io (TNF)] associated with a decrease in input membrane conductance. Io (TNF) was decreased by depolarization and increased by hyperpolarization. The extrapolated reversal potential of Io (TNF) was approximately +10 mV. Ion substitution and pharmacological experiments suggest that Io (TNF) in identified neurons R9 and R10 of A. kurodai is due to a decreased Na+ conductance but not due to an activation of the Na(+)-K+ pump. Our results demonstrate that the immunomodulator TNF can act directly on the nervous system as well as on the immune system. 相似文献
65.
一种新型人TNFα对人肝癌裸鼠移植瘤的抗瘤作用 总被引:1,自引:1,他引:0
用人肝癌Bel7402瘤株建立了人肝癌裸鼠移植瘤模型,探讨新型重组人TNFa对这种移植瘤的抗瘤作用,结果表明,rhTFaD11a和原型重组人TNFa的抑瘤率在30%左右时,后者后用的活性产闰数是前者的2倍;两者用量相同时,前者的抑产经比后者提高23个百分 相似文献
66.
Nigel Wynne RGN/Dip BSc Stuart Brand BSc PhD Roy Smith BA PhD 《Journal of advanced nursing》1997,26(3):470-474
There is an ongoing debate in nurse education concerning the role and delivery of the biological sciences in the nursing curriculum. One of the fundamental questions raised by this debate asks how best can teachers impart biological knowledge in a manner that can be readily applied by students and qualified nurses to inform their clinical practice. This paper will include a discussion of some of the features of pre-registration education that may have influenced the manner in which biological sciences are perceived, taught and used by nurses. It will be argued that nursing may have developed a form of incomplete holism and that this may be in part responsible for the challenges that remain to be met within this area of the nursing curriculum. As a response to incomplete holism an innovative approach within pre-registration education will be introduced. This development involves the use of linked teaching sessions which aim to develop the analytical skills necessary to apply physiological knowledge to nursing practice. 相似文献
67.
模糊数学方法用于职业危害因素的综合评价徐新云(湖南省劳动卫生职业病研究所,长沙410007)用模糊数学方法进行综合评价时,首先要确定评判等级,各评判因素在不同等级中的取值,以及各评判因素的权重系数三方面内容。本文将评判等级定为优、良、一般、差、很差5... 相似文献
68.
Multiplex PCR analysis of in vivo-arising deletion mutations in the hprt gene of human T-lymphocytes
James C. Fuscoe Lisa J. Zimmerman Karen Harrington-Brock Martha M. Moore 《Environmental and molecular mutagenesis》1994,23(2):89-95
A multiplex polymerase chain reaction (PCR) procedure was adapted for the rapid and efficient evaluation of deletions of the hypoxanthine guanine phosphoribosyltransferase (hprt) gene in human T-lymphocytes. The hprt clonal assay was used to isolate in vivo-arising hprt-deficient T-cells from six healthy males. Mutant frequencies ranged from 9-27 × 10?6. Simple crude cellular extracts from 223 mutants were analyzed for hprt gene deletion. Sixteen (7.2%) were found to be due to total gene deletion and 22 (9.9%) were due to partial gene deletion. The relatively high frequency of total gene deletions was caused by replicate isolates of a single mutational event as shown by single-strand conformation polymorphism (SSCP) analysis of rearranged T-cell receptor (TCR)-γ genes. Eighteen of the 22 partial hprt gene deletion mutants were determined to be of independent origin based on a unique hprt mutation or SSCP-TCR-γ pattern. One-half (9/18) of the partial deletion mutants involved all or part of exon 4 alone, suggesting that this region of the hprt gene is prone to deletion. The small deletions effecting exon 1 (1 mutant), exon 2 (2 mutants), and exon 4 (6 mutants) would not have been detected by conventional Southern blot analysis and may represent a new, previously unrecognized class of mutations. The ready isolation of such intragenic deletions will allow the characterization of breakpoint junctions and may provide insights into the important processes of DNA breakage and rejoining. © 1994 Wiley-Liss, Inc. 相似文献
69.
目的 评价血清肿瘤标志物甲胎蛋白(AFP)、癌胚抗原(CEA)、糖类抗原50(CA50)、糖类抗原19—9(CA19—9)、铁蛋白(SF)、神经元特异性烯醇化酶(NSE)、细胞角蛋白19片段(CYFlRA21—1)水平对肺癌诊断的临床价值。方法 测定72例肺癌患者和40例良性肺病患者的血清AFP、CEA、CA50、CA19—9、SF、NSE、CYFRA21—1水平,比较两组的差异。结果 肺癌组患者CEA、CA50、CA19—9、SF、NSE、CY—FRA21—1水平高于良性肺病组,AFP对肺癌的诊断价值不大。NSE CYF、RA21—1的联合检测具有良好的阳性和阴性预测值。六项联合检测的敏感性和准确性最高,但与两项联合检测的敏感性和准确性差异无统计学意义。结论 NSE CYFRA21—1的联合检测具有良好的临床应用前景。 相似文献
70.
精神分裂症患者心理防御机制与人格特征的相关性分析 总被引:7,自引:1,他引:6
目的 探讨精神分裂症患者心理防御方式和人格特片的特点及二者的相关性。方法 分别运用防御方式问卷 (DSQ)和艾森克个性问卷 (EPQ)对 10 1名精神分裂症患者和 30例正常人群进行防御方式评定和人格测定。结果 与正常对照组相比 ,精神分裂症患者更多采用不成熟和中间型防御方式 (P <0 0 5 )。防御方式与人格特征存在着一定的关联性 (P <0 0 5 )。不成熟型防御方式和中间型防御机制与EPQ的精神质 (P)得分和神经质 (N)得分呈显著正相关 (P <0 0 1) ,成熟防御机制与内外向(E)得分呈显著正相关 (P <0 0 5 )。结论 精神分裂症患者更多地使用不成熟防御机制 ,存在病态人格 ,且者之间存在明显相关性 ,有关结果 ,对于探讨精神分裂症患者的病理心理机制和开展心理治疗有指导意义。 相似文献