LDPE／CPE／炭黑三相复合导电体系的电学性能

研究了ＬＤＰＥ／ＣＰＥ／炭黑三相复合导电体系的导性能和电流－电压特性。实验结果表明复合体系具有明显的导电渗滤效应，在共混比ＬＤＰＥ／ＣＰＥ＞５０／５０时，导电性能随ＣＰＥ含量增加而显著提高，这主要是由于炭黑粒子在ＬＤＰＥ和ＣＰＥ两组分分中的分布不均匀性所致。     

二甲苯胺基噻唑的燐光分析法及其吸收分布排泄和动力学研究

二甲苯胺基噻唑与金莲橙OO在pH2.0生成复合物可用氯仿抽提,分离的复合物在盐酸中用锌还原.还原金莲橙有强的燐光,激发波峰302nm,发射波峰442nm,燐光强度与二甲苯胺基噻唑量成正比.用此法研究其在小鼠体内的吸收、分布、排泄及作药物动力学研究.小鼠im二甲苯胺基噻唑10mg/kg后5min,在血、脑、膈、肺、心、肝、脾、肾、尿及胆中都有药物存在.高峰在给药后30min,6h后各组织中还有不少量药物存在,24h内二甲苯胺基噻唑在小鼠尿中排泄25μg,粪便中排泄1.63μg,共计排泄26.6μg,占给药量的9.67%.兔、大鼠、小鼠im二甲苯胺基噻唑10mg/kg后不同时间测血药浓度,作药物动力学分析,其为二室开放模型药物.三种动物的主要动力学参数为:t_(1/2) 126.2,165.4,207.5min;高峰时间35.1,23.5,17.1min;AUC为416.1,298.3,385.2μg-min/ml;廓清率为24,33.7,26ml/min保定宁吸收速率比它快一倍,半吸收期为2.45min,高峰时间为11.7min.     

阿克拉霉素A毫微囊在大鼠体内的组织分布研究＿（1））

本文利用反相高效液相色谱法测定了阿克拉霉素Ａ毫微囊（ＡＣＭ－Ａ－ＮＣ）在大鼠体内各组织的分布．结果表明：阿克拉霉素Ａ在肺、脾、小肠和胸腺分布较多，而心、肝、肾中分布较少．与ＡＣＭ－Ａ水溶液对比研究表明：ＡＣＭ－Ａ－ＮＣ在肺内分布量较其水溶液提高３．６倍，在脾中提高１．４倍，肝中２．２倍，肾中１．６倍，胸脾中１．２倍，大肠１．２倍，小肠１．１倍，心中约１．２倍．     

人体内镭-226含量及分布

本文分析了101例成人骨灰样品和5例成人尸解样品中镭-226和钙的含量。实验范围内,人骨中镭-226含量与年龄及骨中钙含量呈二元线性相关关系。用苏州市人口相应的年龄构成计权的人骨中镭-226含量为(5.99+0.08)×10^-4Bq／g灰。所测各部位骨的骨灰中镭-226含量的差异无显著性意义;不同部位骨的灰化率差异甚大,由尸解样品中镭-226含量估算的人体软组织中镭-226负荷量约占全身负荷量的20%。此外,本文还根据所测骨、肺、肝,胃,小肠、大肠、骨胳肌和皮肤中镭-226含量,对相应受辐射危险的组织进行了剂量估算,并估算了接受镭-226及其短寿命子体所致年剂量后随机性健康效应发生的几率,将随机性建康效应发生的几率与世界癌症发病率最低的国家或地区的相应组织或器官的癌症发病率相比较,发现前者比后者至少低约二个数量级。     

Autopsy findings in two siblings with infantile Refsum disease

Summary Recognition of adrenal atrophy during a review of autopsy findings in two sisters who died at 8 months and 3 1/2 years prompted estimation of very long chain fatty acids, phytanic acid and pristanic acid on wet liver fixed in formalin for 12 years. These were shown to be markedly increased and defects in multiple peroxisomal functions and decrease in particulate catalase were shown in cultured fibroblasts, confirming an abnormality of peroxisomal biogenesis. The patients had presented with failure to thrive, recurrent diarrohea and vomiting, poor mental development, retinal pigmentation, blindness and in the older patient deafness, with only mild dysmorphic features. Autopsy in the older patient showed adrenal atrophy, cirrhosis, and foamy histiocytes in multiple organs. The brain showed no demyelination, little cytoarchitectural abnormality, occasional perivascular histiocytes in the grey matter and meninges and prominent Purkinje cells in the molecular layer of the cerebellum. In the younger patient the changes were very subtle in spite of the marked clinical similarity. Despite the young age at death the clinicopathological features are most suggestive of infantile Refsum disease. In many situations anatomical pathology can be very useful in the recognition and study of peroxisomal disorders.     

CGRP免疫反应神经纤维在大鼠胆总管与十二指肠连接处的分布

用免疫组织化学ＡＢＣ法，研究了降钙素基因相关肽（ＣＧＲＰ）免疫反应神经纤维在大鼠胆总管末端与十二指肠连接处的分布。大鼠的胆总管末端有较丰富的ＣＧＲＰ免疫反应神经纤维，它们多呈串珠（膨体）状，少数为无膨体的细长纤维。ＣＧＲＰ－ＩＲ纤维主要分布肌层及血管周围，在神经纤维的附近可见到含ＣＧＲＰ－ＩＲ阳性颗粒的肥大细胞。本实验为神经免疫调节机制的研究提供了形态学依据。     

避孕措施与细菌性阴道病关系的研究

目的：探讨避孕措施与细菌性阴道病（BV）的关系，为预防BV、指导选择避孕措施提供依据。方法：对某医院妇科门诊接受计划生育服务的育龄妇女非选择性地进行BV筛检。以筛检出的267例BV患者为病例组，其余478例未患BV且无BV史的妇女为对照组进行病例对照研究。结果：与未采用避孕措施者比较，单因素logistic回归分析显示：BV与IUD有正关联，而与避孕套、口服避孕药（OC）无关联。经婚姻状况、性卫生、性行为习惯调整后，BV与IUD的关联仍有统计学意义（OR=2．364，95％C1：1．216～3．620），但与OC及避孕套使用无关。同IUD使用者比较，BV与避孕套使用呈负关联，调整后的OR=0．299（95％C1：0．158～0．566）；BV与OC使用间无关联。结论：使用IUD与未采用避孕措施者比较可能增加BV发生的危险，而避孕套使用者发生BV危险低于IUD使用者。无论从避孕还是预防BV角度，避孕套均是一种较好的选择。     

Patterns of asbestosis in New Jersey.

Hospital discharge data from New Jersey were used to identify cases of asbestosis for the 8 years 1979-1986. Multiple admissions were deleted so that each individual was counted once at the time of his/her first hospitalization with an asbestosis diagnosis. White males had the highest age-adjusted average annual discharge rate of 19.3 cases/100,000 population, followed by black males (12.3 cases/100,000) and white females (1.2 cases/100,000). The discharge rate was positively associated with age in each race/sex category. The relationship between rates for black males and white males depended on age: under 65 years, the rates were almost equal, and at 65 years and older, the white rates were nearly twice the black rates. There were two areas of the state where the rates were highest: the north-central and southwest regions. These two areas represent manufacturing and shipbuilding applications of asbestos, respectively. During the years 1979-1986, the annual percentage increase in asbestosis rates was 20% for white males, 17% for black males, and 8% for white females. Continued surveillance will reveal when the rates for asbestosis stop increasing.     

交链孢酚单甲醚在大鼠小鼠体内的分布

对食管癌高发区粮食中分离的互隔交链孢霉的毒素交链孢酚单甲醚(AME)在大鼠、小鼠体内的分布进行研究。给动物腹腔内注射氚标记的交链孢酚单甲醚(~3H-AME),然后在不同时间测各脏器的放射性。结果表明:在所测9个脏器中,2h肝脏含量最高,食管下段在大小鼠分别居第四和第三。但大小鼠分别在72、24h则以食管下段最高,说明AME及其代谢物在此清除较慢,即对其有较高的亲和力。     

学龄儿童掌指骨发育某些正常变异的观察

１９８０年和１９９０年对１２５９名城乡７～１２岁学龄儿童掌指骨发育的正常变异进行了观察。结果证实，小指中节骨发育变异的检出率最高（总检出率１４．７％），且男女儿童１９９０年此率均高于１９８０年（Ｐ＜０．０５），反映城市儿童该变异近１０年有增高的趋势；１９９０年男女学龄儿童小指中节骨变异检出率城市明显高于农村（Ｐ＜０．０１）；Ⅱ掌骨副骨骺总检出率３．８％，指骨骺核硬化总检出率２．２％，这两种变异男性明显高于女性．且无城乡差异。本观察各年龄组小指中节骨的变异同骨龄无规律性联系。