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991.
Federico Iori Alessio Bruni Salvatore Cozzi Patrizia Ciammella Francesca Di Pressa Luca Boldrini Carlo Greco Valerio Nardone Viola Salvestrini Isacco Desideri Francesca De Felice Cinzia Iotti 《Current oncology (Toronto, Ont.)》2022,29(7):4612
Despite the rising evidence in favor of immunotherapy (IT), the treatment of oncological patients affected by so-called “cold tumors” still represents an open issue. Cold tumors are characterized by an immunosuppressive (so-called cold) tumor microenvironment (TME), which favors host immune system suppression, cancer immune-escape, and a worse response to IT. However, the TME is not a static element, but dynamically mutates and can be changed. Radiotherapy (RT) can modulate a cold microenvironment, rendering it better at tumor killing by priming the quiescent host immune system, with a consequent increase in immunotherapy response. The combination of TME radiomodulation and IT could therefore be a strategy for those patients affected by cold tumors, with limited or no response to IT. Thus, this review aims to provide an easy, rapid, and practical overview of how RT could convert the cold TME and why cold tumor radiomodulation could represent an interesting strategy in combination with IT. 相似文献
992.
Mihajlo Djokic Benjamin Hadzialjevic Branislava Rankovic Rok Dezman Ales Tomazic 《Current oncology (Toronto, Ont.)》2022,29(7):4717
Cystic teratomas are germ cell tumors most commonly found in the ovaries and testes. The pancreas, however, is very rare as a site of occurrence. Moreover, only two cases of cystic teratoma with concomitant neuroendocrine tumor have been reported to date. We report the case of a 33-year-old female who presented with abdominal pain. Computed tomography and magnetic resonance imaging of the upper abdomen revealed an 85 mm cystic tumor in the head of the pancreas. Cystic teratoma and mucinous cystadenoma were suggested as differential diagnoses. Cytopathologic analysis of endoscopic ultrasound-guided fine needle aspiration was consistent with mucinous cystadenoma. Therefore, the patient underwent surgical resection. Histologic analysis revealed a mature cystic teratoma of the pancreas with a concomitant neuroendocrine tumor. The patient is in great condition at 8 months follow-up. Cystic teratoma of the pancreas with a concomitant neuroendocrine tumor is an extremely rare condition. Surgical resection remains the mainstay of treatment as it provides a definitive diagnosis and no recurrences have been reported to date. 相似文献
993.
Tongxia Wang Yan Gao Xi Wang Junrui Tian Yuan Li Bo Yu Cuiyu Huang Hui Li Huamao Liang David M.Irwin Huanran Tan Hongyan Guo 《中国癌症研究》2022,34(2):95-113
Objective: Emerging studies have demonstrated the promising clinical value of circulating tumor cells(CTCs)for diagnosis, disease assessment, treatment monitoring and prognosis in epithelial ovarian cancer. However, the clinical application of CTC remains restricted due to diverse detection techniques with variable sensitivity and specificity and a lack of common standards.Methods: We enrolled 160 patients with epithelial ovarian cancer as the experimental group, and 90 patients including 50 pat... 相似文献
994.
目的 探讨大型桥小脑角肿瘤经乳突后小骨窗开颅、骨片复位的手术方法 及其治疗效果.方法 18例大型桥小脑角肿瘤(听神经鞘瘤13例,脑膜瘤3例,胆脂瘤2例)均采用单侧乳突后小骨窗开颅,应用显微神经外科技术进行肿瘤切除,必要时磨开内听道,术中行脑干听觉诱发电位(BAEP)、体感诱发电位(SEP)和面神经功能监测,肿瘤切除后严密缝合硬脑膜,骨片复位.结果 肿瘤全切除17例、次全切除1例.全组患者的面神经均得到了解剖保留.无手术死亡.术后复查MRI示17例肿瘤全切除者未见有肿瘤残留,1例听神经鞘瘤行次全切除者于内听道内可见少许肿瘤组织残留,术后3个月行伽玛刀治疗.术后有10例遗留轻度面瘫(口角稍有歪斜,眼睑闭合良好),均为大型听神经鞘瘤患者,余患者无脑神经功能障碍,恢复良好.结论乳突后小骨窗开颅术适用于不同大小的桥小脑角肿瘤,严格按显微神经外科技术操作,结合术中BAEP,SEP和面神经功能监测,均可做到肿瘤全切除,并能有效地保护肿瘤周围的重要神经结构及其功能.严密缝合硬脑膜和骨片复位可消除局部皮下积液. 相似文献
995.
目的 借助癌症基因组图谱(TCGA)数据库研究低级别胶质瘤(LGG)组织中补体C3a受体1(C3AR1)的表达水平及其与LGG患者预后及肿瘤免疫细胞浸润的关系.方法 从TCGA数据库下载514例LGG患者的基因表达谱数据和临床信息.比较C3AR1基因在LGG组织和正常组织中的表达水平,分析不同WHO分级LGG组织样本中... 相似文献
996.
997.
Carnot Ntafam Adam T. Miller Bryce D. Beutler Judith Bamporiki Ara B. Sahakian Phillip M. Cheng 《Radiology Case Reports》2022,17(10):3504
Schwannomas are common peripheral nerve sheath tumors that typically occur on the head, neck, trunk, or extremities. Intra-abdominal schwannomas, however, are rare. We describe a young woman who presented for imaging evaluation of suspected nephrolithiasis and was incidentally found to have a schwannoma centered within the pancreatic parenchyma. In addition, we detail the clinical, imaging, and histopathologic features of pancreatic schwannoma and summarize diagnosis and management of this rare clinical entity. 相似文献
998.
999.
目的 探讨高分辨磁共振血管壁成像(magnetic resonance vascular wall imaging,MR-VWI)对颅内动脉瘤(intracranial aneurysm,IA)的诊断价值。方法 选取2020年1月—2021年2月本院收治的动脉瘤患者共58例(70个瘤体),依据动脉瘤破裂与否将其分为A组(破裂,10个瘤体)及B组(未破裂,60个瘤体),同时再将B组依据患者是否存在症状分为B1(有症状12个)及B2(无症状48个)。所有入组患者均经MR-VWI进行检查,对比观察各组间MR检查结果。结果 B组瘤体大小、瘤径宽度、子囊比例、高宽比及瘤径强化分级均明显低于A组患者,差异有统计学意义(P <0.05);B1组患者高宽比及瘤壁强化分级明显高于B2组患者,差异有统计学意义(P <0.05)。结论 使用高分辨MR血管壁成像可有效评估颅内动脉瘤破裂风险,具有无创,高效的优势,值得在临床中进一步推广使用。 相似文献
1000.
Nguyen Duy Hung Le Thanh Dung Dang Khanh Huyen Ngo Quang Duy Dong-Van He Nguyen Minh Duc 《International journal of medical sciences》2022,19(7):1110
Background: Prior studies have suggested a number of the subjective visual characteristics that help distinguish between spinal meningiomas and schwannomas on magnetic resonance imaging and computed tomography; however, objective quantification of the signal intensity can be useful information. This study assessed whether quantitative magnetic resonance imaging (MRI) signal intensity (SI) measurements could distinguish intradural-extramedullary schwannomas from meningiomas.Methods: From July 2019 to September 2021, 54 patients with intradural-extramedullary tumors (37 meningiomas and 17 schwannomas) underwent surgery, and tumors were verified pathologically. Defined regions of interest were used to quantify SI values on T1- (T1W) and T2-weighted images (T2W). Receiver operating characteristic curve analysis was used to obtain cutoff values and calculate the area under the curve (AUC), sensitivity (SE), specificity (SP), positive predictive value (PPV), and negative predictive value (NPV).Results: Both Maximum (T2max) and mean (T2mean) T2W SI values demonstrated outstanding (AUC: 0.91) abilities to differentiate meningiomas from schwannomas with Se, Sp, PPV, and NPV values of 94.6%, 70.6%, 87.5%, and 85.7%, respectively, for T2max and 81.1%, 88.2%, 93.8%, and 68.2% for T2mean. The maximum SI value on contrast-enhanced T1W (T1CEmax) and the T2W tumor: fat SI ratio (rTF) demonstrated acceptable abilities (AUC: 0.73 and 0.79, respectively) to differentiate meningiomas from schwannomas with Se, Sp, PPV, and NPV values of 94.6%, 70.6%, 87.5%, and 85.7%, respectively, for T1CEmax and 81.1%, 88.2%, 93.8%, and 68.2% for rTF.Conclusions: Quantitative SI values (T2max, T2mean, T2min, T1CEmax, rTF) can be used to differentiate intradural-extramedullary schwannomas from meningiomas. 相似文献