全文获取类型
收费全文 | 295366篇 |
免费 | 34779篇 |
国内免费 | 8914篇 |
专业分类
耳鼻咽喉 | 2451篇 |
儿科学 | 3551篇 |
妇产科学 | 6280篇 |
基础医学 | 18414篇 |
口腔科学 | 6675篇 |
临床医学 | 25036篇 |
内科学 | 31424篇 |
皮肤病学 | 2880篇 |
神经病学 | 5980篇 |
特种医学 | 8651篇 |
外国民族医学 | 273篇 |
外科学 | 39394篇 |
综合类 | 41764篇 |
现状与发展 | 46篇 |
一般理论 | 7篇 |
预防医学 | 16459篇 |
眼科学 | 1717篇 |
药学 | 23011篇 |
291篇 | |
中国医学 | 14061篇 |
肿瘤学 | 90694篇 |
出版年
2024年 | 1009篇 |
2023年 | 5856篇 |
2022年 | 11358篇 |
2021年 | 14851篇 |
2020年 | 14336篇 |
2019年 | 12403篇 |
2018年 | 11873篇 |
2017年 | 12548篇 |
2016年 | 13643篇 |
2015年 | 14994篇 |
2014年 | 23218篇 |
2013年 | 24883篇 |
2012年 | 19457篇 |
2011年 | 19996篇 |
2010年 | 15251篇 |
2009年 | 14838篇 |
2008年 | 14459篇 |
2007年 | 14019篇 |
2006年 | 12430篇 |
2005年 | 10290篇 |
2004年 | 8529篇 |
2003年 | 7171篇 |
2002年 | 6055篇 |
2001年 | 5337篇 |
2000年 | 4436篇 |
1999年 | 3695篇 |
1998年 | 3072篇 |
1997年 | 2757篇 |
1996年 | 2247篇 |
1995年 | 2050篇 |
1994年 | 1748篇 |
1993年 | 1387篇 |
1992年 | 1220篇 |
1991年 | 1086篇 |
1990年 | 813篇 |
1989年 | 767篇 |
1988年 | 655篇 |
1987年 | 593篇 |
1986年 | 486篇 |
1985年 | 633篇 |
1984年 | 509篇 |
1983年 | 333篇 |
1982年 | 375篇 |
1981年 | 322篇 |
1980年 | 282篇 |
1979年 | 240篇 |
1978年 | 142篇 |
1977年 | 120篇 |
1976年 | 102篇 |
1975年 | 62篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
51.
B. A. Stoll 《Annals of oncology》1997,8(3):223-225
Background: The study reviews the anticancer properties of naturalisoflavones which occur in especially high concentration in soybeans. Itconsiders the suitability of soybean products for clinical trials aiming toreduce the progression of breast cancer.Methods: Evidence is reviewed that plant isoflavones such asgenistein show cytostatic activity against human mammary cancer cell linesin vitro and can also suppress carcinogen-induced mammary cancer inyoung and mature rats.Results: Plant isoflavones are converted in the bowel to compoundswith potential antioestrogenic and antioxidative properties. These compoundsshow cytostatic activity for both oestrogen receptor-positive and negativehuman mammary cancer cell lines, and also inhibit growth and progress of therat mammary cancer model. The high content of soybean products in the diet ofAsian women has been postulated as one reason for their relatively low breastcancer incidence.Conclusion: Preclinical studies suggest that soybean products begiven priority for clinical trials in breast cancer protection. A pilot studycould test soy protein supplements as long-term adjuvant dietary treatmentafter primary surgery for early breast cancer, looking for a decrease in therisk of recurrence or of second primary tumours. 相似文献
52.
ANDREW BOTTOMLEY 《European journal of cancer care》1997,6(1):11-17
Cancer causes significatlt emotional distress to a considerable majority of patients. Many of these patients typically receive little formal psychological intervention. Support groups, however, have provided one forum from which patients can attempt to gain help and can use to overcome some psychological trauma that accompanies the cancer hagnosis, subsequent treatment and relapse. This article reviews past studies of professionally run cancer support groups as opposed to psychological intervention groups. These studies are considered in light of the proposed benefits and the methodological limitations frequently inherent in such studies. 相似文献
53.
A. Heinig S. H. Heywang-Köbrunner P. Viehweg D. Lampe J. Buchmann R. P. Spielmann 《Der Radiologe》1997,37(9):710-717
Summary
Early recognition of recurrence and work-up of clinically indeterminate lesions may be impaired after reconstruction with
silicone implants due to superimposition of the implant or to scarring. This study was undertaken to evaluate the use of contrast-enhanced
MRI in patients with silicone implant after breast cancer. Contrast-enhanded MRI was offered to 169 patients. Comparative
two- to three-view mammography was also performed in 169 patients, as well as comparative sonography in 144 patients. Conventional
imaging and clinical examination detected only 8/13 recurrences, whereas 12/13 were detected by MRI. One recurrence had been
visible as a strongly enhancing 2-mm dot in a previous examination (2 years before), but was not called. It was therefore
counted as false negative. In addition, multicentricity was detected by MRI alone in two of three cases. MRI correctly diagnosed
scar tissue in all cases with indeterminate findings. However, due to false-positive calls caused by enhancing granulomas
specificity could not be improved. Contrast-enhanded MRI allowed decisive additional information in our study group and improved
the sensitivity significantly (concerning all diagnoses). Contrast-enhanded MRI is recommended in patients with diagnostic
problems or high risk of recurrence after silicone implants.
相似文献
54.
Background: The bariatric patient exists in dynamic relationship with family members and friends who have considerable influence
upon the patient and his or her surgical outcome. When family members and friends behave as intimate saboteurs, they attempt
to hamper, hurt, or subvert the bariatric patient's goal of achieving and maintaining a healthy body weight. Successful or
not, intimate saboteurs provide significant treatment challenges for the patient and the treatment team. Methods and Patients:
Patient profiles provide examples of intimate sabotage. The psychological construct of Family Systems Theory is used as a
plausible explanation for the sabotage of friends and family. Conclusions: Multidisciplinary professionals treating the bariatric
patient must be aware of the critical influence of intimate saboteurs and the tactics they use to sabotage. Treatment guidelines
recommended by Family Systems Theory are presented as strategies to mitigate the influence of intimate saboteurs. 相似文献
55.
A. G. D. Maran J. A. Wilson M. N. Gaze 《European archives of oto-rhino-laryngology》1993,250(3):127-132
Summary Squamous cell carcinoma of the head and neck is a disease predominantly of males and is due to a variety of known environmental irritants, notably cigarette smoke. Dietary, viral and immunological factors may also be relevant. Head and neck squamous cancers express epidermal growth factor receptors and some show weak levels of oestrogen receptor activity, but a reliable serum marker of tumour burden remains to be identified. The prognosis is found to be less favourable in females, in those with advanced T stage, in association with multiple node involvement, especially where extracapsular spread is present and where the T4/T8 ratio is elevated. Administration of heterologous blood during therapy may also have an adverse effect on prognosis. Interested clinicians must remember that most cases are preventable.
Correspondence to: A.G.D. Maran 相似文献
56.
57.
38例非小细胞癌脑转移的综合治疗分析 总被引:1,自引:1,他引:0
目的探讨非小细胞肺癌脑转移的有效治疗方案.方法对38例非小细胞肺癌脑转移患者进行头部、胸部放疗并结合全身化疗的综合治疗.结果近期疗效的有效率为76.3%(29/38).神经精神症状缓解率73.7%(28/38),肺部症状缓解率60.5%(23/38).1年生存率31.5%(12/38),2 a生存率10.5%(4/38).结论合理采用综合治疗可有效提高非小细胞肺癌脑转移患者的生存率. 相似文献
58.
Anorectal function in the solitary rectal ulcer syndrome 总被引:8,自引:6,他引:2
Nigel R. Womack F.R.C.S. Professor Norman S. Williams M.S. John H. Holmfield Mist John F. Morrison Ph.d. 《Diseases of the colon and rectum》1987,30(5):319-323
The anorectal function of nine patients with solitary rectal ulcer syndrome (SRUS) (5 F: 4 M, median age, 27 (range, 19–41
years) and nine control subjects (5 F: 4 M, median age, 47 (35–66)P<0.01) has been investigated by a new technique that radiologically visualizes the anorectum during voiding of a semisolid
contrast medium, while simultaneously measuring intrarectal pressure and anal sphincter EMG activity. A degree of rectal prolapse
was demonstrated in eight of the SRUS patients; six of these lesions were clinically occult. Abnormal failure of the anal
sphincter to relax on voiding was present in seven of the SRUS patients. These abnormalities resulted in the SRUS patients
requiring a greater increase in intrarectal pressure (median, 100 cm water) to void than the control subjects (median, 65
cm water,P<0.01). This combination of high intrarectal pressure and rectal prolapse during straining seems to be the cause of SRUS
This work was supported by a grant from the Medical Research Council. 相似文献
59.
H. Draper 《Journal of Renal Care》2002,28(Z2):39-42
The majority of patients being treated for acute renal failure in intensive care units have multiple medical problems. Accordingly, the withdrawal of renal replacement therapies should be considered as part of a general decision about whether to initiate or continue with treatment per se. Several guidelines on withdrawing and withholding therapy have been produced and some common themes emerge: concerns to avoid euthanasia, potential for benefit, patient consent (shared decision‐making), team consensus/decision‐making, and the provision of appropriate palliative care and resource implications. Each of these is considered in turn, although the word limit for this paper does not permit detailed exposition. 相似文献
60.
本文报道了气管切开术各种并发症的发病率,并对术中或术后并发症的病的病因、发病机理、治疗和预防进行了讨论。 相似文献