黄芪建中汤联合西药治疗消化性溃疡随机平行对照研究

[目的]观察黄芪建中汤联合西药治疗消化性溃疡疗效。[方法]使用随机平行对照方法,将200例门诊患者按随机数字表法分为两组。对照组100例雷尼替丁,150mg/次,2次/d。阿莫西林,1g/次,3次/d。吗叮啉,20mg/次,3次/d,餐前30min口服。治疗组100例黄芪建中汤(黄芪20g,炒白芍18g,桂枝、生姜各9g,炙甘草6g,大枣5枚,饴糖30g),1剂/d,水煎200mL,早晚口服。泛吐清水加干姜、吴茱萸、法半夏、茯苓;寒盛合附子理中汤;脾虚湿盛加陈皮、半夏;肾阳虚加巴戟天、仙茅;胃阴虚加石斛、沙参、玉竹;淤血合失笑散;肝气郁积合柴胡疏肝散;饮食停滞合保和丸;西药治疗同对照组。连续治疗28d为1疗程。观测临床症状、不良反应。治疗1疗程,判定疗效。[结果]治疗组痊愈60例,显效37例,有效2例,无效1例,总有效率99.00%。对照组痊愈47例,显效33例,有效11例,无效9例,总有效率89.00%。治疗组疗效优于对照组(P0.05)。[结论]黄芪建中汤联合西药治疗消化性溃疡效果显著,值得推广。     

Epidermal Neural Crest Stem Cells (EPI-NCSC) and Pluripotency

This article serves three purposes. We summarize current knowledge of the origin and characteristics of EPI-NCSC, review their application in a mouse model of spinal cord injury, and we present new data that highlight aspects of pluripotency of EPI-NCSC. EPI-NCSC are multipotent stem cells, which are derived from the embryonic neural crest and are located in the bulge of hair follicles. EPI-NCSC can undergo self-renewal and they are able to generate all major neural crest derivatives, including neurons, nerve supporting cells, smooth muscle cells, bone/cartilage cells and melanocytes. Despite their ectodermal origin, neural crest cells can also generate cell types that typically are derived from mesoderm. We were therefore interested in exploring aspects of EPI-NCSC pluripotency. We here show that EPI-NCSC can fuse with adult skeletal muscle fibers and that incorporated EPI-NCSC nuclei are functional. Furthermore, we show that adult skeletal muscle represents an environment conducive to long-term survival of neurogenic EPI-NCSC. Genes used to create induced pluripotent stem (iPS) cells are present in our EPI-NCSC longSAGE gene expression library. Here we have corroborated this notion by real-time PCR. Our results show similarities in the expression of Myc, Klf4, Sox2 and Lin28 genes between EPI-NCSC and embryonic stem cells (ESC). In contrast there were major differences in Nanog and Pou5f1 (Oct-4) expression levels between EPI-NCSC and ESC, possibly explaining why EPI-NCSC are not tumorigenic. Overall, as embryonic remnants in an adult location EPI-NCSC show several attractive characteristics for future cell replacement therapy and/or biomedical engineering: Due to their ability to migrate, EPI-NCSC can be isolated as a highly pure population of multipotent stem cells by minimally-invasive procedures. The cells can be expanded in vitro into millions of stem cells/progenitors and they share some characteristics with pluripotent stem cells without being tumorigenic. Since the patients’ own EPI-NCSC could be used for autologous transplantation, this would avoid graft rejection.     

热必宁治疗外感高热急症的临床研究

本文采用以清、解、和、下四法联用而设计的热必宁治疗外感高热急症３００例，并与西药对照组１１２例及单用清热解毒法治疗组６４例进行比较。结果治疗组退热时间短，明显优于西药对照组及单用清热解毒法组，经统计学处理，有显著性差异，并且其症状、体征改善迅速。文中还对治法、服药方法及疗效机理等进行了探讨。     

林毅治疗乳腺增生病的经验

从病因病机、治法方药、生活调养三方面论述了林毅教授治疗乳腺增生病的经验,强调中西相参、辨证辨病、中医药周期治疗、内外合治、重视调护的学术特点     

铅的肾细胞毒性及锌的保护作用

铅的肾细胞毒性及锌的保护作用陈卫平，刘世杰（北京医科大学公共卫生学院，１０００８３）本实验采用由猪肾脏起源建株并具有肾近曲小管功能的ＬＬＣ－ＰＫ１细胞系，从细胞水平上研究了铅对肾细胞的毒性及锌的保护作用。所选用的指标为细胞存活率和上清液中的乳酸脱氢酶...     

功能性消化不良的中西联合治疗方法探究

现代医学多根据其临床表现,采用抑酸剂、胃肠动力药进行相应的对症治疗,近年来随着精神心理因素对胃肠动力影响的研究成为热点,较多的研究证实了长期情志不畅、抑郁可导致．FD,这与中医肝主疏泄,主调情志的观点不谋而和。本文对功能性消化不良的甲西联合治疗方法进行了探讨。     

Cauliflower-like Neoplasm of Duodenal Papilla in a Liver Transplant Recipient: What Should We Think and Do? A Case Report

Background

With the continuous improvement of liver transplantation technology, the survival rate of liver transplantation has been improved, but recurrent or de novo malignancy remains one of the major factors affecting the long-term survival of liver transplant recipients.

临潼温泉水漂浮疗法对老年原发性高血压病的疗效观察

目的 观察以解放军临潼第一疗养院温泉水作为漂浮液的漂浮疗法对老年原发性高血压病的治疗效果。方法 以随机抽样的方式将我院1998年3月至2001年3月收住院的患有原发性高血压病的疗养员分为漂浮组和对照组。两组疗养员均继续服用医嘱降血压药,并且均进行基础疗养措施,但漂浮组增加应用温泉水为漂浮液的漂浮治疗,治疗前后分别填写SCL－90症状自评量表,对照观察两组疗效。结果 经1个月疗养后,漂浮组病人的收缩压与舒张压均明显下降,有效率为67％;而对照组有效率仅为13％。两组疗养员的精神症状均有改善,以漂浮组改善更为明显。结论：临潼温泉水漂浮疗法是治疗原发性高血压病的有效辅助治疗方法。     

林洁从“阳化气,阴成形”论治多囊卵巢综合征

多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者的卵泡发育异常与阳化气,阴成形功能失衡密切相关。在PCOS患者的月经周期变化中,阳化气与阴成形的功能失调常见两种阴阳失衡表现。其一是阴成形不足,阳化气相对过盛;其二是阴成形太过,阳化气乏力。林洁教授将PCOS患者从胖、瘦两种体型辨证施治,瘦型PCOS患者的发病之本为阳化气太过,其标为阴成形不足,多辨为心肝火旺证,采用以丹栀逍遥散为基础方化裁的多囊Ⅰ号方治疗;胖型PCOS患者发病之本为阳化气乏力,其标为阴成形太过,采用以导痰汤为基础化裁的多囊Ⅱ号方治疗。另外,属患者养成健康的饮食习惯和良好的生活习惯,选择适合的运动方式,病情严重者进行必要的心理疏导。