Combined Therapy with Transarterial Chemoembolization and Radiofrequency Ablation for Hepatocellular Carcinoma: Does the Degree of Ethiodized Oil Accumulation within the Tumor Affect the Therapeutic Efficacy?

Purpose

To evaluate the effects of the degree of ethiodized oil accumulation achieved by transarterial chemoembolization followed by radiofrequency (RF) ablation on the treatment efficacy for a single intermediate-sized hepatocellular carcinoma (HCC).

Expression of Pituitary Tumor Transforming Gene 1 is an Independent Factor of Poor Prognosis in Localized or Locally Advanced Prostate Cancer Cases Receiving Hormone Therapy

We investigated the prognostic value of pituitary tumor transforming gene 1 (PTTG1) expression according toclinicopathological features among localized or locally advanced prostate cancer cases receiving hormone therapy.A retrospective study involved 64 patients receiving combined androgen blockade treatment was performed.PTTG1 expression was determined by immunohistochemical staining using initial needle biopsy specimensfor diagnosis. Associations of PTTG1 with various clinicopathological features and disease-free survival wereexamined via uni- and multivariate analyses. No association between PTTG1 expression and clinical T stage,Gleason score, pretreatment PSA levels, risk groups was found (p =0.682, 0.184, 0.487, 0.571, respectively).Univariate analysis revealed that increased PTTG1 expression, T3 stage and high risk group were associatedwith increased risk of disease progression (p =0.000, 0.042, and 0.001), and high PSA level had a tendency topredict disease progression (p =0.056). Cox hazard ratio analysis showed that PTTG1 low expression (p =0.002),PTTG1 high expression (p =0.000) and high risk group (p =0.0147) were significantly related to decreased diseasefreesurvival. In conclusion, PTTG1 expression determined by immunohistochemical staining in needle biopsyspecimens for diagnosis is a negative prognostic factor for progression in localized or locally advanced prostatecancer receiving hormone therapy.     

Prognostic impact of neoadjuvant chemotherapy induced neutropenia on operable breast cancer

Objective To evaluate the relationship between neoadjuvant chemotherapy (combination of taxanes and anthracyclines) induced-neutropenia and the efficacy of neoadjuvant chemotherapy and longterm survival in operable breast cancer patients. Methods Two hundred and eleven patients received 4 cycles of neoadjuvant chemotherapy     

Simultaneous measurement of the viability,aggregation, and live and dead adherence of Streptococcus crista,Streptococcus mutans and Actinobacillus actinomycetemcomitans in human saliva in relation to indices of caries,dental plaque and periodontal disease

Salivary proteins have multiple functions and many share similar functions, which may be why it has been difficult to relate variations in their concentrations to oral health and ecology. An alternative is to focus on variations in the major functions of saliva. An hydroxyapatite-coated microplate model has been developed that simultaneously measures saliva-promoted bacterial viability, bacterial aggregation, and live and dead bacterial adherence, while simulating oral temperature and shearing forces from swallowing. That model was applied to resting whole and stimulated parotid saliva from 149 individuals, using representative strains of Streptococcus crista, S. mutans, and Actinobacillus actinomycetemcomitans. Two major factors were defined by multivariate analysis (this was successful only for whole-saliva). One factor was correlated with aggregation, live adherence and dead adherence for all three strains; the other was correlated with total viability of all three strains. Participants were grouped <25th percentile and >75th percentile for each factor. Those groups were compared for clinical indices of oral health. Caries scores were significantly lower in those with high scores for aggregation-adherence, regardless of whether total viability scores were low or high. Live bacteria always predominated on surfaces when live and dead adherence scores were expressed as ratios. However, participants with high scores for aggregation-adherence showed significantly more dead adherent bacteria than those with low scores (these ratios were uncorrelated with total viability). This finding may indicate that extreme differences in the ability to kill bacteria on surfaces can influence caries risk.     

Does the Increased Rate of Serous Component (≤25% vs. >25%) Increase Recurrence in Endometrial Cancer With Serous Plus Endometrioid Histology?

Objective

The aim of the study is to investigate the effect of increasing serous component ratio on survival in endometrium cancer patients with serous plus endometrioid histology.

HLA-inferred extended haplotype disparity level is more relevant than the level of HLA mismatch alone for the patients survival and GvHD in T cell-replate hematopoietic stem cell transplantation from unrelated donor

Serious risks in unrelated hematopoietic stem cell transplantation (HSCT) including graft versus host disease (GvHD) and mortality are associated with HLA disparity between donor and recipient. The increased risks might be dependent on disparity in not-routinely-tested multiple polymorphisms in genetically dense MHC region, being organized in combinations of two extended MHC haplotypes (Ehp). We assessed the clinical role of donor-recipient Ehp disparity levels in N?=?889 patients by the population-based detection of HLA allele phase mismatch. We found increased GvHD incidences and mortality rates with increasing Ehp mismatch level even with the same HLA mismatch level. In multivariate analysis HLA mismatch levels were excluded from models and Ehp disparity level remained independent prognostic factor for high grade acute GvHD (p?=?0.000037, HR?=?10.68, 95%CI 5.50–32.5) and extended chronic GvHD (p?<?0.000001, HR?=?15.51, CI95% 5.36–44.8). In group with single HLA mismatch, patients with double Ehp disparity had worse 5-year overall survival (45% vs. 56%, p?=?0.00065, HR?=?4.05, CI95% 1.69–9.71) and non-relapse mortality (40% vs. 31%, p?=?0.00037, HR?=?5.63, CI95% 2.04–15.5) than patients with single Ehp disparity. We conclude that Ehp-linked factors contribute to the high morbidity and mortality in recipients given HLA-mismatched unrelated transplant and Ehp matching should be considered in clinical HSCT.     

胃癌HER-2表达与术后辅助化疗疗效的相关性分析

目的 通过总结胃癌术后辅助化疗病例及HER-2表达情况,探讨HER-2表达与胃癌术后辅助化疗疗效之间的相关性.方法 回顾性分析185例胃癌术后辅助化疗患者资料,总结其病理特点、HER-2表达状况及无疾病进展生存(DFS)、总生存(OS),分析HER-2与临床病理特点及DFS、OS的关系.结果 185例胃癌患者中,HER-2阴性141例,阳性44例,阳性率24％.HER-2基因的扩增与肿瘤部位、肿瘤的分化程度及远处转移部位相关,与年龄、性别、分期无关;HER-2阳性组中位DFS为9.1个月,中位OS为15.1个月,HER-2阴性组中位DFS为15.2个月,中位OS为25.5个月,HER-2阴性的患者较HER-2阳性的患者更能从术后辅助化疗中获益(P=0.046),并且生存期更长(P=0.01).结论 HER-2无扩增的患者可从术后辅助治疗中获益,DFS与OS均有延长.