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81.
目的:比较不同化疗疗程对早期卵巢上皮癌患者生存率和无瘤生存率的影响。方法180例患者按预后风险因素及化疗疗程分组,无瘤生存率及生存率采用Kaplan-Meier法估算,采用Log-Rank检验进行比较。结果≤4疗程(Ⅰ组)及﹥4疗程(Ⅱ组)5年总生存率(5-OS)、2年无瘤生存率(2-DFS)及5年无瘤生存率(5-DFS)分别为54.1%、51.6%、47.8%,48.3%、41.8%、40.0%;两组5-OS、2-DFS 及5-DFS 的差异均无统计学意义(P=0.926,P=0.713)。高危组和低危组患者5-OS、2-DFS 及5-DFS 分别为45.6%、84.7%,38.5%、93.5%,32.9%、77.5%;两组5-OS、2-DFS及5-DFS差异有统计学意义(P均=0.000)。高危组中≤4疗程(A1组)及﹥4疗程(A2组)5-OS、2-DFS及5-DFS分别为39.6%、48.5%,26.8%、43.7%,26.8%、36.0%;两组5-OS差异无统计学意义(P=0.314),A1组2-DFS及5-DFS均低于A2组(P=0.011)。低危组中≤4疗程化疗及﹥4疗程5-OS、2-DFS及5-DFS分别为85.1%、83.3%,95.0%、90.9%,77.7%、77.9%;两组5-OS、2-DFS及5-DFS差异无统计学意义(P>0.5)。结论高危组早期上皮性卵巢癌患者术后予大于4疗程化疗可提高其无瘤生存率。 相似文献
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Jong Eun Lee Jin Woong Kim Hyoung Ook Kim Byung Chan Lee Young Hoe Hur Sung Bum Cho Yong Soo Cho Hyun Ju Seon DongHun Kim 《Journal of vascular and interventional radiology : JVIR》2019,30(3):370-379.e4
Purpose
To evaluate the effects of the degree of ethiodized oil accumulation achieved by transarterial chemoembolization followed by radiofrequency (RF) ablation on the treatment efficacy for a single intermediate-sized hepatocellular carcinoma (HCC).Materials and Methods
A total of 153 consecutive patients who underwent chemoembolization and RF ablation for a single intermediate-sized HCC (2–5 cm) were included. On the basis of the degree of ethiodized oil accumulation in HCC on cone-beam CT images, patients who underwent chemoembolization and RF ablation were classified into 2 groups: compact accumulation (≥ 75%) and noncompact accumulation (< 75%). The rates of cumulative local tumor progression (LTP), disease-free survival (DFS), and overall survival (OS) were compared between groups.Results
Of the 153 patients, 89 were classified into the compact ethiodized oil accumulation group and 64 in the noncompact ethiodized oil accumulation group. There were no significant differences in patient demographic or HCC characteristics between groups except for the incidence of liver cirrhosis (P = .038) and the tumor margin morphology (P = .008). The cumulative LTP rate was significantly lower in the compact accumulation group than in the noncompact accumulation group (P = .013). There were no significant differences in the incidences of complications, DFS rates (P = .055), or OS rates (P = .184).Conclusions
The degree of ethiodized oil accumulation does not play a role in decreasing the OS or DFS rate after chemoembolization and RF ablation for intermediate-sized HCC; however, it may contribute to reducing the rate of LTP. 相似文献85.
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Expression of Pituitary Tumor Transforming Gene 1 is an Independent Factor of Poor Prognosis in Localized or Locally Advanced Prostate Cancer Cases Receiving Hormone Therapy
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《Asian Pacific journal of cancer prevention》2012,13(7):3083-3088
We investigated the prognostic value of pituitary tumor transforming gene 1 (PTTG1) expression according toclinicopathological features among localized or locally advanced prostate cancer cases receiving hormone therapy.A retrospective study involved 64 patients receiving combined androgen blockade treatment was performed.PTTG1 expression was determined by immunohistochemical staining using initial needle biopsy specimensfor diagnosis. Associations of PTTG1 with various clinicopathological features and disease-free survival wereexamined via uni- and multivariate analyses. No association between PTTG1 expression and clinical T stage,Gleason score, pretreatment PSA levels, risk groups was found (p =0.682, 0.184, 0.487, 0.571, respectively).Univariate analysis revealed that increased PTTG1 expression, T3 stage and high risk group were associatedwith increased risk of disease progression (p =0.000, 0.042, and 0.001), and high PSA level had a tendency topredict disease progression (p =0.056). Cox hazard ratio analysis showed that PTTG1 low expression (p =0.002),PTTG1 high expression (p =0.000) and high risk group (p =0.0147) were significantly related to decreased diseasefreesurvival. In conclusion, PTTG1 expression determined by immunohistochemical staining in needle biopsyspecimens for diagnosis is a negative prognostic factor for progression in localized or locally advanced prostatecancer receiving hormone therapy. 相似文献
87.
韩芸蔚 《外科研究与新技术》2012,(1):6-6
Objective To evaluate the relationship between neoadjuvant chemotherapy (combination of taxanes and anthracyclines) induced-neutropenia and the efficacy of neoadjuvant chemotherapy and longterm survival in operable breast cancer patients. Methods Two hundred and eleven patients received 4 cycles of neoadjuvant chemotherapy 相似文献
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Salivary proteins have multiple functions and many share similar functions, which may be why it has been difficult to relate variations in their concentrations to oral health and ecology. An alternative is to focus on variations in the major functions of saliva. An hydroxyapatite-coated microplate model has been developed that simultaneously measures saliva-promoted bacterial viability, bacterial aggregation, and live and dead bacterial adherence, while simulating oral temperature and shearing forces from swallowing. That model was applied to resting whole and stimulated parotid saliva from 149 individuals, using representative strains of Streptococcus crista, S. mutans, and Actinobacillus actinomycetemcomitans. Two major factors were defined by multivariate analysis (this was successful only for whole-saliva). One factor was correlated with aggregation, live adherence and dead adherence for all three strains; the other was correlated with total viability of all three strains. Participants were grouped <25th percentile and >75th percentile for each factor. Those groups were compared for clinical indices of oral health. Caries scores were significantly lower in those with high scores for aggregation-adherence, regardless of whether total viability scores were low or high. Live bacteria always predominated on surfaces when live and dead adherence scores were expressed as ratios. However, participants with high scores for aggregation-adherence showed significantly more dead adherent bacteria than those with low scores (these ratios were uncorrelated with total viability). This finding may indicate that extreme differences in the ability to kill bacteria on surfaces can influence caries risk. 相似文献
90.
Alpaslan Kaban Samet Topuz Hamdullah Sozen Yavuz Salihoglu 《Journal d'obstetrique et gynecologie du Canada》2019,41(2):160-165