High NUSAP1 expression predicts poor prognosis in colon cancer

Background and aim

Nucleolar and spindle-associated protein 1 (NUSAP1) is an indispensable mitotic regulator. Aberrant NUSAP1 expression is associated with perturbed mitosis and tumorigenesis. In this study, we investigated the clinical significance of NUSAP1 expression in colon cancer.

Predicting anxiety during dental treatment using patients'self-reports: less is more

BACKGROUND: Self-reported dental fear measures seldom are used in clinical practice to assess patients' fears. This study examined how well dental fear measures predicted anxious behaviors displayed during dental treatment. METHODS: One hundred eight adult patients (54 percent female) in a periodontology clinic completed several paper-and-pencil demographic, dental fear and general anxiety measures before treatment. Dental practitioners, blinded to their patients' responses, rated their patients' anxiety during treatment on a series of 100-millimeter visual analog scales. RESULTS: Higher Dental Fear Survey scores, younger age, more invasive treatment type and previous avoidance of dental care because of a bad experience all were predictive of greater observed anxiety. Neither self-reported nor observed anxiety was affected by previous experience with a particular practitioner or treatment. CONCLUSIONS: Dentists may assess patients' anxiety quickly and accurately with the Dental Fear Survey or a similar measure, as well as by asking patients about their current dental attendance and previous dental experiences.     

针刺疗法配合康复训练治疗脑梗塞后吞咽障碍(DFS)的疗效观察

目的:观察针刺疗法配合康复训练治疗脑梗塞后吞咽障碍(DFS)的疗效。方法:从2011年2月到2013年2月,于我院共有96例病患被诊断为脑梗塞后吞咽障碍,以数字法随机分成观察组(48例)和对照组(48例),两组病患均进行康复训练。对照组不进行针刺治疗;观察组在此基础上进行针刺治疗。对比两组疗效及拔管率及拔管时间。结果:观察组效果为优的病患占37.50%(18/48),改善率为89.58%(43/48),均优于对照组的18.75%(9/48),58.33%(28/48),差异均有统计学意义(均P0.05)。观察组治疗后拔管时间为13.02±6.55天,明显少于对照组治疗后拔管时间,差异均有统计学意义(均P0.05)。治疗后,观察组拔管的病患占100%(48/48),明显高于对照组的58.33%(28/48),差异均有统计学意义(均P0.05)。结论:针刺疗法配合康复训练治疗脑梗塞后DFS,不仅可明显改善吞咽障碍,还可以减少拔管所需时间,提高拔管率,安全性好,值得临床推荐。     

Metastatic Axillary Lymph Node Ratio (LNR) is Prognostically Superior to pN Staging in Patients with Breast Cancer - Results for 804 Chinese Patients from a Single Institution

The number of axillary lymph nodes involved and retrieved are important prognostic factors in breast cancer.The purpose of our study was to investigate whether the lymph node ratio (LNR) is a better prognostic factor inpredicting disease-free survival (DFS) for breast cancer patients as compared with pN staging. The analysis wasbased on 804 breast cancer patients who had underwent axillary lymph node dissection between 1999 and 2008in Sun Yat-Sen University Cancer Center. Optimal cutoff points of LNR were calculated using X-tile softwareand validated by bootstrapping. Patients were then divided into three groups (low-, intermediate-, and high-risk)according to the cutoff points. Predicting risk factors for relapse were performed according to Cox proportionalhazards analysis. DFS was estimated using the Kaplan-Meier method and compared by the log-rank test. The5-year DFS rate decreased significantly with increasing LNRs and pN. Univariate analysis found that the pT ,pN, LNR, molecule type, HER2, pTNM stage and radiotherapy well classified patients with significantly differentprognosis. By multivariate analysis, only LNR classification was retained as an independent prognostic factor.Furthermore, there was a significant prognostic difference among different LNR categories for pN2 category,but no apparent prognostic difference was seen between different pN categories in any LNR category. Therefore,LNR rather than pN staging is preferable in predicting DFS in node positive breast cancer patients, and routineclinical decision-making should take the LNR into consideration.     

飞利浦64排螺旋CT数据采集系统故障维修

本文介绍了CT数据采集系统的组成以及其功能,并通过其各个组成部分的功能分析,解决其运行中遇到的故障。     

Survival outcome of weak estrogen/progesterone receptor expression in HER2 negative breast cancer is similar to triple negative breast cancer

Background

Recent publications have suggested that human epidermal growth factor receptor 2 (HER2)-negative breast cancers with “weak” estrogen receptor (ER)/progesterone receptor (PR) expression levels by immunohistochemical (IHC) analysis were considered as the triple-negative (TN) subtype. This study aimed to evaluate the overall survival (OS), disease-free survival rates (DFS), and disease-specific survival (DSS) based on ER and PR expression levels into one of three groups, ER and PR <1%, ER and PR 1%–20%, and ER or PR >20% by hormone therapy.

Loss of Secreted Frizzled-Related Protein-1 expression is associated with poor prognosis in intrahepatic cholangiocarcinoma

Aims

Secreted Frizzled-Related Protein-1 (SFRP1) is a well-known negative regulator of the wingless type (Wnt)-β-catenin pathway and its inactivation plays an important role in the development and progression of many cancers. In this study, we aimed to determine the clinical significance of SFRP1 expression in intrahepatic cholangiocarcinoma (IHCC) and to define the relationship to Wnt-β-catenin pathway.