庚辰年运气初析

运用五运六气学说分析庚辰年的气候特点为金运太过,全年气候干燥少雨,凡阴虚,血虚体质者应注意保养津液。     

女性抗精神病药物源性内分泌紊乱的中药治疗

目的:观察中药二陈汤加减对女性患者抗精神病药物(AP)源性脂质代谢及内分泌紊乱的疗效及安全性,并探讨女性抗精神病药物源性内分泌紊乱的机制。方法:对44例符合入组标准的女性精神分裂症患者进行治疗,总疗程30天。所有患者在服用中药治疗前后检测血清催乳素(PRL)、雌二醇(E2)、睾酮(T)。并于治疗前后分别做心电图、血常规及尿常规检查。结果:治疗后患者血清催乳素、睾酮水平均下降,且与治疗前有显著性差异(P<0.01);雌二醇水平较治疗前显著上升(P<0.01)。治疗前后的心电图及血、尿常规检查亦未发现明显改变。结论:中药二陈汤加减有显著降低血清催乳素及睾酮水平以及提高血清雌二醇水平的作用,改善AP源性内分泌紊乱;且安全性较好,是一种治疗抗精神病药物源性内分泌紊乱的较为理想的方药。     

云南血竭中的三个配糖体

从云南‘雨林牌’血竭Ｄｒａｃａｅｎａ ｃｏｃｈｉｎｃｈｉｎｅｎｂｓｉｓ （Ｌｏｕｒ．）Ｓ．Ｃ．Ｃｈｅｎ中分离鉴定了一个新的酚苷：３,４－二羟基烯丙基苯４－Ｏ－「α－Ｌ－鼠李吡喃糖基（１→６）」－β－Ｄ葡萄吡喃糖苷,２个已知的甾体皂苷：２６－Ｏ－β－Ｄ－葡萄吡喃糖夫甾烷－５,２０（２２）,２５（２７）－三烯－１β,３β,２６－三醇－１－Ｏ－「α－Ｌ－鼠李吡喃糖基（１→２）－α－Ｌ－葡萄吡喃糖基－呋甾     

温热联合细胞周期特异性药物对恶性胸膜间皮瘤细胞的影响

通过体外实验研究温热联合细胞周期特异性药物羟基喜树碱（ＯＰＴ）对ＳＭＣ１ 恶性胸膜间皮瘤细胞株的影响。结果显示：经０１ μｇ／ｍ ｌ、１０ μｇ／ｍ ｌ、１００ μｇ／ｍ ｌＯＰＴ 处理４８ ｈ 对ＳＭＣ１ 细胞增殖有抑制作用,其抑制作用具有药物浓度依赖性,流式细胞仪测定显示经ＯＰＴ处理后细胞周期出现改变,Ｓ期细胞下降,Ｇ２＋ Ｍ 期细胞增加（Ｐ＜ ００５ 或Ｐ＜ ００１）;单独加温３９℃、４１℃、４３℃６０ ｍ ｉｎ 对ＳＭＣ１ 细胞增殖同样具有抑制作用,并有温度依赖性;温热联合ＯＰＴ 对ＳＭＣ１ 细胞增殖具有最佳抑制效果,该效果显现出温度药物浓度依赖性。该实验为临床应用提供了一定的理论依据     

二陈汤在妇科肿瘤手术后的应用

目的 :观察二陈汤在妇科恶性肿瘤手术后的辅助治疗效果。方法 :36例患者 ,随机分为治疗组 (2 4例 )和对照组 (12例 ) ,对肿瘤病灶、临床症状、生活质量和实验室检查等进行了治疗和对比。结果 :在获得相同肿瘤疗效的情况下 ,治疗组的症候改善明显优于对照组 (P≤ 0 0 1或 0 0 5 ) ,且无明显的不良反应。结论 :二陈汤在妇科恶性肿瘤手术后的辅助治疗中具有较好的疗效。     

Brain evoked potentials are functional correlates of induced pain in man.

Electrical potentials evoked by 5 intensities of painful dental stimulation were recorded at the scalp. During testing, volunteers indicated subjective painfulness by verbal pain ratings and visual analogue scales. Evoked potentials (EPs) to each intensity, observed between 50 and 400 msec, were characterized by 4 waveform components. The peak-to-peak amplitudes, but not the peak latencies, of all 4 EP components systematically increased with increased stimulation. The amplitudes of the two earlier components correlated with stimulus intensity when the effect of subjective painfulness was controlled, but this was not the case for the later components. In contrast, the amplitudes of the two later components were associated with subjective painfulness but not with stimulus intensity. A strong linear relationship was observed between subjective painfulness and peak-to-peak amplitude for the EP component observed between 175 and 260 msec. The data suggest that the earlier EP components may reflect sensory transmission processes while the later components indicate brain activity when pain is perceived.     

Inhibitory effect of Panax notoginseng on nitric oxide synthase, cyclo-oxygenase-2 and neutrophil functions

A water extract of Panax notoginseng Buck F.H. Chen. (Arialiaceae) root (PN) is being used as a therapeutic agent to stop haemorrhages and as a tonic to promote health in Korean and Chinese medicine. The pharmacokinetic profiles of PN have not been accurately investigated. The preliminary aim was to elucidate the pharmacokinetic features of PN. First, the prevention of neutrophil functions was assessed. PN inhibited neutrophil functions, including degranulation, superoxide generation and leukotriene B4 production, without any effect on 5-lipoxygenase activity. PN reduced nitric oxide (NO) and prostaglandin (PG)E2 production in mouse peritoneal macrophages stimulated with lipopolysaccharide (LPS) while no influence on the activity of inducible NO synthase (iNOS), cyclo-oxygenase-2 (COX-2) or cyclo-oxygenase-1 (COX-1) was observed. PN significantly reduced mouse paw oedema induced by carrageenan. The results indicate that PN exerts antiinflammatory effects related to the inhibition of neutrophil functions and NO and PGE2 production, which could be due to a decreased expression of iNOS and COX-2.     

二陈汤配方颗粒与传统煎剂的化学成分比较

目的：采用色谱法对二陈汤配方颗粒剂与传统煎剂中的化学成分进行比较，建立配方颗粒剂的定性鉴别方法。方法：用不同溶剂提取的部位，采用TLC、GC、HPLC及氨基酸分析仪对其配方颗粒与传统煎剂中化学成分进行定性鉴别比较。结果：配方颗粒剂与传统煎剂的色谱图基本一致。结论：此法准确、简便，可作为配方颗粒剂与传统煎剂的鉴别。     

陈亦人教授运用芍药甘草汤的经验

芍药甘草汤具有养阴血、柔筋脉、舒挛缓急的功效，主治筋脉挛急之证。介绍陈亦人教授运用芍药甘草汤的经验，并附验案分析。