传染病研究40年（1955～1995年）

本文综述本校传染病学教研室１９５５～１９９５年间所取得的科研成果。内容包括１０余种传染病与寄生虫病的临床和基础研究，其中以华支睾吸虫病、恙虫病等有广东特色的传染病以及伤寒、痢疾、病毒性肝炎等影响人民健康最普遍的传染病为重点。反映了建国以来各个时期本教研室对防治这些传染病所作的贡献。所取得的成果，相当一部分通过多年来的验证，已获得广大传染病工作者所认同或列为常规，部分已获得部委级奖励。现在重温这些成果，可能起承前启后的意义。     

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目的 探讨乳腺导管内乳头状瘤(intraductal papillomas，IP)癌变的临床表现、生物学行为、诊断、治疗及预后。方法 对1980年1月至2001年12月间7例IP癌变病人临床资料进行回顾性分析。结果 7例IP癌变占同期113例IP的5．19％，术前均未能确诊，5例术中冰冻考虑IP癌变。结论 IP有癌变潜能，其癌变者术前确诊困难，术中冰冻对诊断治疗意义重大，应重视术后随访。     

聚合酶链反应单链构象多态性检测乳腺癌中P53基因突变

应用聚合酶链反应单链构象多态性方法，对２４例原发性乳腺癌肿瘤组织基因组ＤＮＡ进行了分析，结果表明：其中７例存在Ｐ５３基因的突变，突变频率约为３０％。同时对其中１０例进行Ｓｏｕｔｅｒｎｂｌｏｔ分析，有２例在ｃｈｒ１７Ｐ上存在等位基因的缺失，而其另一等位基因上均存在基因突变。     

沈阳口岸入出境人员传染病监测工作报告

本文阐述了1990年-1993年间沈阳口岸入境人员传染病监测工作的基本情况，在对6503名归国人员和2146名外籍人员进行传染病监测体检中，发现HIV感染者41人、隐性梅毒患者1人、开放性肺结核患者1人。     

男性乳腺癌研究进展

男性乳腺癌是一种少见的恶性肿瘤。本文综述与男性乳腺癌相关的分子生物学特征(BRCA-1、BRCA-2、HER-2/new、p53 Bcl-2 p21waf1、p27kip1)、诊断、治疗。诊断主要依靠病理学;淋巴结转移是主要预后因素。治疗以手术为主,综合治疗有利于提高生存率。     

女性乳头湿疹样癌与乳腺癌浸润乳头之间区别的探讨

本文对１９８０～１９８２年间．天津肿瘤医院收治可手术原发女性乳腺癌７１５侧重新复习。根据镜下在乳头皮肤见到ｐａｇｅｔ细胞以及癌直接浸润（或累及）乳头，确定乳头湿疹样癌２０例，乳腺癌浸润乳头６９例。比较两组在临床表现、病理形态和预后的差异。结果发现，乳头湿疹样癌的临床表现以乳头糜烂，结痂为主，而乳腺癌浸润乳头则以乳头凹陷、皮肤粘连、桔皮样变和乳头抬高为主；镜下形态，乳头湿疹样癌主要是在乳头表皮内见到Ｐａｇｅｔ细胞，晚期亦可浸及乳头基质。乳腺癌浸润乳头主要特点是癌细胞浸润乳腺导管，管壁可完整或被浸破，癌亦可直接浸润乳头基质，绝大多数皮肤正常，直接累及皮肤少见，均无Ｐａｇｅｔ细胞。通过本文研究，作者认为乳头湿疹样癌为乳腺癌的独立类型，其在临床表现、病理形态及预后等方面，均与乳腺癌浸润乳头有显著区别。     

血清唾液酸对血液病临床价值的初步报告

报道64例各类血液病患血清唾液酸（SA）值的测定，并与84例健康对照组进行比较。结果经统计学分析：病例组（631．5±130．3μg/ml），病例组中的ANLL（672．6±98．38μg/ml），ALL（630．8±29．3μg/ml），CML－A（617．5±122．7μg/ml），MM（606．0±138．7μg/ml四组与对照组比较，差异有极显意义（P＜0．01）；各病型组SA阳性率明显高于健康对照组，表明SA值的测定对恶性血液病的诊断有一定的临床意义。     

纤维结合素角膜上皮愈合作用的研究

人血浆纤维结合素对家兔刮除和板层切除后的角膜上皮愈合均有一定促进作用，角膜上皮裸区明显缩小，优于对照眼。临床治疗５类角膜上皮障碍５９例６１眼，均获得显著疗效。     

Post-treatment sarcoma in breast cancer patients

Background: Many patients treated for breast cancer with radiotherapy will survive their disease and be at risk for treatment-related sarcoma for many years. Methods: In order to identify patients with post-treatment sarcoma and define this disease, we examined the records of 99 patients treated for sarcoma with a history of antecedent breast carcinoma. Of these patients, 51 were felt to have a sarcoma unrelated to breast cancer treatment and 48 were felt to have a treatment-related sarcoma (secondary to lymphedema and/or radiation). Results: Lymphangiosarcoma of the extremity was the most common histologic subtype of post-treatment sarcoma, accounting for 22 of 48 cases (46%). Twenty-six patients (54%) developed nonlymphangiosarcoma post-treatment sarcoma; all of these were radiation-associated sarcomas. The median latency interval between the diagnosis of breast cancer and the development of sarcoma was 11 years (range 4–44) and was not different between the two groups. However, patients with nonlymphangiosarcoma were significantly younger when diagnosed with breast cancer than were those with lymphangiosarcoma of the extremity (median 43 vs. 51 years, p<0.001). The survival of all 48 patients was poor: 5-year survival was 29%. Five-year survival of patients with other types of post-treatment sarcoma was just as poor as those with lymphangiosarcoma of the extremity (30% vs. 28%, p=0.98). Conclusions: Patients who develop sarcoma after treatment for breast cancer have a poor prognosis whether it occurs as Stewart-Treves syndrome or other types of post-treatment sarcoma. Younger patients may be at higher risk than are older patients for the development of nonlymphangiosarcoma post-treatment sarcoma.Presented at the 46th Annual Cancer Symposium of the Society of Surgical Oncology, Los Angeles, March 18–21, 1993.