流式细胞光度术在鼻咽癌上皮样细胞株细胞周期动力学研究中的应用

本实验应用流式细胞光度术研究鼻咽癌上皮样细胞株（ＣＮＥ）的细胞周期动力学。结果发现ＣＮＥ细胞仍保持原代细胞的ＤＮＡ含量水平（超三倍体和亚四倍体），随着细胞接种时间的延长细胞周期中Ｇ０／Ｇ１时相细胞的百分数逐渐升高，而Ｓ％和Ｇ２＋Ｍ％则逐渐降低。该项研究还发现随着孵育时间的延长，细胞周期中各时相细胞的运动均逐渐延缓，其中以Ｇ０／Ｇ１和Ｇ２＋Ｍ时相细胞的运动减慢较为明显。     

中国人与白种人鼻咽癌的发病和治疗

对1971—1990年间加拿大不列颠哥伦比亚癌症中心收治的428例鼻咽癌病人的发病和治疗情况进行分析。其中,中国人占303例(71％),白种人116例(27％)。中国人在该省鼻咽癌的年发病率是白种人的64倍,其中又以在中国出生的发病率最高,分别为白种人的104倍和北美出生的中国人的16倍。本组总的5年和10年生存率分别为51％和39％,颈淋巴结阴性的病人5年生存率达64％;而阳性的病人只有44％。鼻咽癌的预后与它的临床分期、病理类型、治疗前有无做颈淋巴结活检,以及性别有关,而与病人的人种和出生地无关。     

两组不同放化疗方案治疗中晚期鼻咽部鳞癌的比较

目的:比较两组不同化疗方案对鼻咽部鳞癌的疗效和毒性.方法:统计分析用FCS(氟脲嘧啶、卡铂、新福菌素)方案和FP(氟脲嘧啶、顺铂)方案治疗的122例中晚期鼻咽部鳞癌的临床资料.结果:FCS组有效率为93.3%,其中完全缓解率为40.0%;FP组有效率为45.2%,其中完全缓解率为3.2%,两组疗效有显著性差异(P＜0.001).毒副反应主要为脱发、胃肠道反应.结论:FCS方案为治疗中晚期鼻咽癌的有效而安全的化疗方案.     

以动眼神经麻痹为首发症状的鼻咽癌2例

病例1,男,36岁,因左眼半固定只能向外移动4个月余,于1994年4月到我院门诊诊治。1994年1月,患者无明显诱因而出现左眼处于半固定状态,只能向外移动,同时同侧上睑下垂,瞳孔散大,对光及节反射消失,在外院眼科多次就诊无效。患者1个月前出现左侧头痛、左耳闷胀,听力下降,在外院耳鼻咽喉科就诊,并行鼻咽部活检2次,均未见癌细     

46例首诊伴远处转移鼻咽癌的预后分析

Objective To retrospectively analyze the therapeutic results of patients with initially di-agnosed metastatic nasopharyngeal carcinoma (NPC). Methods From January 1995 to December 1998, 46 NPC patients with distant metastases were treated in Fujian provincial cancer hospital. Among these pa-tients, 43 were single site metastasis and 3 were multiple sites metastases;The site of metastasis were 19 pa-tients in the liver, 11 in the bone, 7 in the lung, 1 in the brain, 6 in mediastinal nodes and 6 in axillary lymph nodes. All patients received standard radiotherapy to the primary site and cervical node region with a median dose of 72 Gy. Forty-one patients (89%) received 1-5 cycles chemotherapy (cisplatin and 5-flu-orouracil), and 23 (50%) received palliative irradiation to the metastatic site. Results The median surviv-al time was 20 months. The 1-, 2-, 3-year and 5-year overall survival rates were 66%, 47%, 30% and 19%, respectively. Irradiation to the metastatic sites and KPS were the significant prognostic factors. Pa-tients with palliative irradiation to the metastatic site had longer survival than those without (39 months vs. 13 months, X2=8.63, P=0.012). Patients with good performance status (KPS≥80) had better outcomes thanthose with poor performance status (26 months vs. 12 months, X2= 3.95, P=0.035) . Conclusions Active therapy may prolong the survival of patients with initially diagnosed metastatic NPC, especially for those who have good performance status. Under systematic chemotherapy, radiotherapy to the primary site and supportive care, the palliative irradiation to the metastatic site may also yield a good result.     

晚期鼻咽癌放射后药物治疗观察

晚期鼻咽癌放射后药物治疗观察泉州市国专医院陈忠户，侯晋国，苏桂治为探讨降低晚期鼻咽癌远处转移、提高存活率的方法，１９８９年１月～１９９１年１月我们对一组Ⅲ、Ⅳ期鼻咽癌放射后进行药物治疗，现将结果报道如下。一、资料和方法（一）病例选择：按长沙会议制定的...     

鼻咽癌12例误诊分析

报告了鼻咽癌误诊病例12例,对其误诊原因进行了分析。认为误诊原因与鼻咽癌的部位隐匿、症状各异、无特殊性有关,还与对鼻咽癌警惕性不高、对鼻咽癌的头痛认识不足、偏重辅助检查以及对颈部淋巴结肿大掉以轻心有关。另外,对鼻咽癌早期诊断进行了讨论。     

两个鼻咽癌家族聚集现象观察

两个鼻咽癌家族聚集现象观察王安宇，王绍丰，钟伟宏广西医科大学肿瘤医院（南宁５３００２７）广西玉林县王氏家族王氏家族两代２１人中，有７人（４农、１工、１教师、１不明）先后患鼻咽低分化鳞癌，其中４人为同胞兄弟，患者年龄为４１～５２岁，５例接受过放疗，６例...