妥泰治疗具有中央颞区棘波的儿童良性癫痫的疗效观察

我们从2001～2004年对32例诊断为具有中央颞区棘波的小儿良性癫癎的患儿进行了妥泰治疗，对其疗效、脑电图变化及不良反应等方面进行了总结。     

SPM5软件分析癫痫患者脑PET图像的应用研究

Objective To investigate the value of statistical parametric mapping 5 (SPM5) and its parameter settings in analysis of PET imaging for epilepsy patients. Methods Seventeen epilepsy patients and seventeen controls were scanned with PET. The datns were analyzed using PET and SPM5 with qualitative and semiquantitative analysis, statistical analysis of the percentage (numbers of agent distribution decreasing in focus to brain) for different parameters combinations, which were value adjustment to contral-p and voxels-k. Results There was decreasing of agent distribution at temporal lobe in epilepsy patients detecting with PET; the T/NT of focus to cerebellum was 1.07±0.24, the T/NT of normal tissue in opposite side to cerebellum was 1.27±0.18, there was a significant difference (t=1.87, P<0.05). Dealing with SPM5, there was more significant decreasing of agent in regions 19, 21, 39 of temporal lobe, regions 7, 19, 31, 40, 47 of parietal lobe and occipital lobe in epilepsy patients. With different value of k, the percentage was (27±22)%, (29±24)%, (32±23)%, (35±27)%, (39±31)%respectively, there was not significant difference (F=0.59, P>0.05) ; for different value of p, the percentage was (42±30) %, (29±25) %, (26±21) % respectively, with a significant difference (F=3.60, P<0.05); there was linear regression in value adjustment to contral-p and the percentage(b=-18.24, t=2.57, P<0.05). Conclusions Semiquantitative analysis by SPM5, the setting of value adjustment to contral-p would affect the results, the smaller of value adjustment to contral-p, the better of the result. SPM5 would be more objective and accurate to locate the focuses.     

立体定向开放显微手术治疗脑内致痫小病灶

目的脑内致癫痫小病灶术前、术中的精确定位和病灶切除,是手术治疗效果的关键。探讨立体定向开放微创手术,皮层电极监测下切除脑内致痫小病灶的手术方法。方法53例症状性癫痫病例,CT、MR I检查有脑内小病灶(直径在0.5~3.0 cm),24 h视频脑电图确认致痫灶为脑内单发病灶。ASA 601S型立体定向仪CT引导辅助全麻环钻开颅,导针穿刺放置导管引导,显微镜下手术分离、切除病灶,皮层脑电图确认将致痫灶切除。结果病灶全切率达96.2%,术后50例得到随访,随访时间5~12个月,平均6.3个月,癫痫消失45例,脑电图检查记录到癫痫波11例,临床癫痫发作5例。因肺癌死亡3例。结论CT立体定向引导,显微手术切除颅内致痫小病灶,术中皮层电极确认将致痫灶切除,是一种定位精确、微创、安全、有效的治疗方法。     

上班路上的一次『羊癫风』现场急救

正是上班高峰,马路上人来车往,汽车站台前更是人头攒动。突然,人群中有人惊叫起来“有人晕倒了”。 说来也巧,我和同事正拎着急救箱出诊。见到这种情形,怎能袖手旁观呢? 我用力推开众人,挤到倒地者的跟前。蜷曲着倒在地上的是一个中年男子,他面色苍白,两眼上翻,呼吸很急促,牙关紧咬着,嘴角有些许呕吐物,手     

儿童24 h脑电Holter 3 026例分析及检查方法

目的:分析3 026例儿童患者24 h脑电Holter资料及检查方法.方法:采用24 h脑电Holter监测.结果:儿童癫痫用此方法阳性率高.结论:24 h脑电Holter对儿童癫痫的诊断具有独特的应用价值.     

复杂部分性癫痫状态四例

复杂部分性癫痫状态四例赵康仁韩泰然例１男，２５岁。反复发作意识不清伴咀嚼、解钮扣等动作２年。一般持续３～５分钟，诊断颞叶癫痫。２年中有５次发作持续１小时以上，其中１次持续１２小时，表现乱语、外出乱跑、冲动行为，事后患者不能回忆。就诊时发作已２小时，意...     

L—NAME促进大鼠红藻氨酸诱导性发作

为证明癫痫发作早期一氧化氮（ＮＯ）抗发作效应，用ＮＯ合酶（ＮＯＳ）抑制剂Ｌ－硝基精氨酸甲酯（Ｌ－ＮＡＭＥ）对大鼠红藻氨酸（ＫＡ）诱导性发作进行干预，同时用分光光度法检测海马结构中ＮＯＳ活性的早期变化。发现ＫＡ发作１０ｍｉｎ、３０ｍｉｎ组海马结构中ＮＯＳ活性明显升高，而ＫＡ注射前３０ｍｉｎ给予Ｌ－ＮＡＭＥ可显著抑制ＮＯＳ活性的升高，这种抑制效应与大鼠ＫＡ发作中湿狗样摇动（ＷＤＳ）的提早出现和发生次数增多显著相关。结果提示在ＫＡ诱导大鼠发作早期内源性ＮＯ具有明显的抗发作效用。     

剥夺睡眠诱发试验对提高癫痫脑电图阳性率的作用(附60例分析)

对60例癫痛患者常规脑电图检查:异常2例,异常率3.33％,正常48例,界限10例;剥夺睡眠诱发试验异常27例,异常率45％,正常33例,经卡方（X~2=26.19）检验,差异性非常显著（P<0.01）。表明,剥夺睡眠诱发试验的阳性率明显提高。     

定痫丸治疗癫痫27例疗效观察

癫痫是一种发作性脑功能短暂异常的疾病,属难治之病。我们用自拟定痫丸治疗癫痫27例,疗效满意,现将治疗观察结果。报道如下: 一、临床资料本组27例均为门诊病人,临床具备典型的癫痫发作症状,结合病史和脑电图情况,均符合《实用内科学》所提示的诊断标准和发作类型。27例中,大发作5例,局限性发作3例,