天麻二至方治疗肝肾阴虚型中老年高血压病101例临床观察

目的:观察天麻二至方对中老年高血压病辨证为阴虚阳亢证者的临床疗效。方法:采用随机分组阳性药物(天麻首乌片)平行对照、双盲观察临床试验设计方案,观察受试病例135例,其中治疗组101例,对照组34例。治疗组用天麻二至方治疗,对照组用天麻首乌片治疗,疗程30d。结果:对照组证候疗效总有效率79.4%,治疗组证候疗效总有效率89.1%;降压疗效方面:对照组总有效率67.6%,治疗组总有效率82.2%,两组比较,差异均有统计学意义。结论:天麻二至方能显著改善患者证候和降低血压。     

杨森主任医师治疗脑梗塞经验拾零

杨森主任医师认为脑梗塞的发生、发展与饮食、情志关系密切,气虚血瘀为其病本,故治宜益气活血,同时应重视饮食及情志的调护。     

Apoptosis induced by chemotherapeutic agents involves c-Jun N-terminal kinase activation in sarcoma cell lines.

Molecular mechanisms underlying chemotherapeutic agent-induced apoptosis in sarcoma cells are not well known. Induction of apoptosis is regulated by several components including mitogen-activated protein kinases (MAPKs) comprising ERK, p38MAPKs, and c-Jun N-terminal kinase (JNK). In the present study, we examined whether activation of JNK is induced by the chemotherapeutic agents cis-diaminedichloroplatinum (cisplatin, CDDP) or doxorubicin (DXR), and whether the ectopic expression of constitutively active (MKK7-JNK1) or dominant-negative form of JNK (dnJNK) influenced apoptosis in response to the CDDP or DXR in sarcoma cell lines MG-63 and SaOS-2. The CDDP or DXR induced JNK activation in the both cell lines, as assessed by Western blotting using phosphospecific antibodies. A transient expression of the activated form of JNK sensitized the MG-63 and SaOS-2 cells to the drug-induced apoptosis, while dnJNK1 reduced the proportion of apoptotic cell death. Apoptosis was determined by flow cytometry using annexin-V Cy5. Collectively, our results indicate that JNK activation is involved in apoptotic cell death in sarcoma cell lines following stimulation with CDDP or DXR.     

十二指肠球部溃疡脾虚证与组胺及胃酸关系初探

本文检测了十二指肠球部溃疡患者及正常人球、胃粘膜内组胺含量及胃酸分泌量变化,结果显示:部分脾虚患者球部粘膜内局部组胺释放功能较非脾虚低下(P<0.05);在溃疡活动期,脾虚和非脾虚患者泌酸功能均增高,而非脾虚患者泌酸功能更高。非活动期阶段,中医证型及病理基础发生质的变化,此时脾虚患者表现为泌酸功能低下。     

杨培君教授治疗心绞痛

杨培君教授认为,冠心病多发于老年前期及老年期,绝经后妇女随着年龄增长发病率也呈逐年增加趋势,表明该病发病与衰老关系密切.并提出:肾虚是冠心痛心绞痛发病的始动病机.其内在机制为肾精亏损日久,致心血不充,心脉失养,不荣则痛;肾阳虚衰可进一步导致心阳不足,行血无力,导致他脏功能亦虚,共同作用于机体形成痰浊、血瘀、寒凝、气滞等病理产物和病理过程,最终导致心脉不通,不通则痛.在临证遣方用药时,注重在化痰、活血、行气等祛邪治标的基础上配伍补肾固本之品.     

香砂六君丸抗十二指肠溃疡复发66例

将 1 2 7例确诊为十二指肠溃疡 ,且内镜下溃疡愈合为红色或白色瘢痕期的患者按接受治疗的先后分为治疗组 66例和对照组 61例。治疗组用香砂六君丸进行抗复发治疗 6个月 ,对照组继续服用雷尼替丁或法莫替丁维持治疗 6个月。结果 ,停药后 1年内 ,治疗组的复发率为 2 5.6% ,对照组的复发率为 62 .3% ,两组复发率经X2 检验 ,差异有非常显著性 ,P <0 .0 1。表明香砂六君丸具有很好的抗十二指肠溃疡复发的作用。同时发现 ,香砂六君丸对脾胃虚寒型的抗复发作用明显优于脾虚胃热型 ,P <0 .0 5,对幽门螺杆菌(HP) 亦有较好的根除作用。     

Change in Proteinuria or Albuminuria as a Surrogate for Cardiovascular and Other Major Clinical Outcomes: A Systematic Review and Meta-analysis

Background

There is ongoing controversy around the surrogacy of proteinuria or albuminuria, particularly for cardiovascular (CV) outcomes, which remain the leading cause of morbidity and mortality among patients with chronic kidney disease. We performed a systematic review and meta-analysis of the literature to assess the surrogacy of changing proteinuria or albuminuria for CV events, end-stage renal disease (ESRD), and all-cause mortality.