磁处理白酒对小鼠4种脏器中NO含量的影响

目的：探讨磁处理白对小鼠脑、肝脏、心脏和肾脏中ＮＯ含量的影响。方法：采用重氮化反应法。结论磁酒组小鼠脑奖浆中ＮＯ含量明显低于白酒组,白酒组脑匀浆ＮＯ含量明显高于对照组,磁酒组和白酒组小鼠肝匀浆ＮＯ含量明显低于对照组,小鼠心匀浆和肾匀浆ＮＯ含量三绷间差异均无统计意义。结论：磁酒对小鼠脑和肝脏的ＮＯ含量有一定影响。     

仙附,芪地强心口服液治疗老年人慢性心功能不全

目的：寻求老年人心功能不全有效、安全的治法方药。方法：用仙附、芪地强心口服液与巯甲丙脯酸对照治疗老年心功能不全,观察心脏功能和血浆血管活性肽、临床症状、体征及药物安全性。结果：仙附、芪地强心口服液和巯甲丙脯酸治疗心功能不全总有效率分别为８７．５％（２８／３２）、９０．３％（２８／３１）、９０．６％（２９／３２）,三者差别无显著性（Ｐ＞０．０５）;在临床近期治愈率方面,分别为４３．８％（１４／３２）、５１．６（１６／３１）、２５．０％（８／３２）,芪地组优于巯甲丙脯酸对照组;对改善患者临床症状、体征、心脏功能和血浆血管活性肽指标等方面都显示明显效果。结论：老年人心功能不全可以益气养阴、温阳治本、活血利水治标为基本大法,仙附、芪地强心口服液是治疗本病的安全有效方药     

元首口服液对家兔血清磷脂酰胆碱∶胆固醇酰基转移酶活性的影响

用元首口服液喂养家兔１个月，测定其前后血清总胆固醇、游离胆固醇、高密度脂蛋白胆固醇（ＨＤＬ－Ｃ）的含量，结果表明，元首口服液有明显提高家兔血清中的磷脂酰胆碱∶胆固醇酰基转移酶（ＬＣＡＴ）活性（Ｐ＜０．００１），提高血清ＨＤＬ－Ｃ含量（Ｐ＜０．００１）。     

水蛭地龙提取液治疗急性脑梗死的作用机制及疗效

目的探讨水蛭地龙提取液(extractliquorfromhirudoandearthworm,ELHE)治疗急性脑梗死的作用机制及疗效。方法78例急性脑梗死患者被随机分为2组:对照组38例,进行基础治疗;治疗组40例,在基础治疗的同时静脉给予ELHE(20ml+等渗盐水250ml,静脉滴注,1次/d,连续2周)。观察2组脑梗死患者治疗前、后神经功能评分、Barthel指数及活化部分凝血活酶时间(APTT)、血浆凝血酶原时间(PT)、组织型纤溶酶原激活物(tPA)、纤溶酶原激活物的抑制剂(PAI1),以及血栓烷B2(TXB2)、6酮前列腺素(6KetoPG)Flα的变化。结果ELHE组患者经过14d治疗,其神经功能缺失评分由9.4±4.0下降为3.3±1.2,Barthel指数由25.9±4.6升高为67.4±2.8,APTT、PT分别由(28.2±3.8)s、(12.2±3.5)s延长为(42.0±5.2)s、(19.5±2.1)s,血浆tPA含量及活性分别由(10.1±1.2)μg/L、(0.27±0.03)KIU/L升高为(15.3±2.1)μg/L、(0.57±0.12)KIU/L,血浆PAI1含量及活性由(47.8±4.6)μg/L和(0.77±0.12)KAU/L下降为(44.2±3.0)μg/L和(0.68±0.11)KAU/L,血栓烷B2由(228.4±48.9)ng/L降低为(152.7±44.4)ng/L,6KetoPGF1a由(21.9±6.3)ng/L升高为(33.8±6.4)ng/L,与对照组比较差异均有显著意义(P<0.05)。结论ELHE具有明显抗凝、促纤溶、抑制血小板聚集,改善血液循     

New Mexico's 1998 drive-up liquor window closure. Study I: effect on alcohol-involved crashes

Aims To determine the spatial relationship between drive‐up liquor window locations and alcohol‐related traffic crashes for 2 years before and after New Mexico banned drive‐through alcohol sales. Design Current liquor licenses, crash data, roadway information and US Census data were used in this analysis. Cross‐sectional and longitudinal regression analyses were applied to the entire state, and to Albuquerque only. Findings Of all NM liquor licenses, 189 (9%) included drive‐up sales, which co‐occurred with on‐ or off‐premise licenses (94%). The rate of non‐pedestrian alcohol‐related crashes relative to non‐pedestrian total crashes showed an increasing trend prior to closure and a decreasing trend after the closure. Cross‐sectional analyses in Albuquerque revealed that the percentage of alcohol‐involved crashes was not related to densities of on‐ or off‐premise outlets per kilometer of roadway, or to percentage of drive‐up outlets. Statewide, the percentage of drive‐up outlets was not significantly related to the percentage of alcohol‐related crashes within census tracts but was associated positively with the percentage of alcohol‐related crashes in surrounding census tracts. There was no statistically significant relationship between number of drive‐ups and percentage of alcohol‐related crashes in either longitudinal model. Conclusions Despite the declining rate of alcohol‐related crashes following closure of drive‐up liquor windows, both in Albuquerque and statewide, regression models using spatial data do not demonstrate definitively an association between the decline and the closure of the drive‐up liquor windows.     

仙人掌汁外用对变应性接触性皮炎的影响

目的 了解仙人掌对皮炎湿疹类疾病的作用及其机制。方法 以豚鼠变应性接触性皮炎(ACD)作为动物模型，仙人掌汁外用，观察其皮肤反应强度、病理变化及真皮有核细胞浸润数。结果 皮肤反应强度比较，实验组与地塞米松组无显著性差异(P＞0．05)，而与对照组比较，有极显著性差异(P＜0．01)；真皮有核细胞浸润数，实验组与另两组比较其值均有极显著性差异(P＜0．01)，地塞米松组作用更强。结论 仙人掌汁外用对豚鼠ACD有显著的抑制作用，能减轻炎症反应强度，减少有核细胞浸润的数目。     

Alcohol and cardiovascular diseases

With respect to cardiovascular disorders, epidemiologic studies support the hypothesis of increased risks among heavy alcohol drinkers and indicate a lower risk among lighter drinkers. Increased cardiovascular risks of heavy drinking include cardiomyopathy, systemic hypertension, supraventricular arrhythmias, hemorrhagic stroke and heart failure that is not associated with coronary artery disease (CAD). Light-to-moderate drinking is probably unrelated to increased risk of any cardiovascular condition and is related to lower risks of CAD, ischemic stroke and CAD-related heart failure. A protective alcohol–CAD hypothesis is supported by plausible biological mechanisms attributable to ethyl alcohol. Possible nonalcohol beneficial components in wine (especially red) could explain the extra protection of wine, but a healthier pattern of drinking or more favorable risk traits in wine drinkers may also be involved. Advice regarding the advisability of alcohol drinking for health needs to be individualized according to specific risks and benefits.     

复方黄芪口服液的实验研究

研究了由黄芪、党参、当归、枸杞子等组成的复方口服液的制备工艺及质量标准，对某些药理作用进行了初步探讨，结果表明该口服液能显著提高小鼠耐缺氧能力，可延长小鼠游泳时间、有抗疲劳作用。     

磁处理酒对血清高密度脂蛋白亚组分胆固醇的影响

目的　探讨经特定磁场强度处理的白酒 ,对人体血清总胆固醇 (TC)和高密度脂蛋白 (HDL)亚组分胆固醇含量的影响。方法　 4 0名健康成年男性饮磁处理酒 30d ,分别测定饮酒前后血清TC和HDL亚组分胆固醇 ,并进行前后比较分析。结果　饮酒 30d后与饮酒前比较血清TC显著降低 (P <0 .0 5 ) ,HDL CH、HDL2 CH含量显著升高 (P <0 .0 5 ) ,HDL3 CH含量无明显差异 (P >0 .0 5 )。结论　磁处理酒具有降低血清TC ,升高血清HDL CH、HDL2 CH的作用。     

术前补液预防术中低血压的效果观察

目的观察术前补液预防术中低血压发生的效果。方法选择择期手术患者128例。随机分成2组,观察组术前1h开始补充乳酸钠林格氏液500ml,根据患者情况适量补充电解质,观察组患者手术前、手术中30min、60min血压的变化及低血压发生情况。结果2组患者收缩压和舒张压手术中30min、60min与手术前比较有统计学意义(P<0.01)。结论手术前1h开始补液能有效地降低术中低血压的发生率。