应用活络油预防压疮的观察与护理

目的为卧床病人寻找一种方便、经济、有效的方法预防压疮。方法使用活络油与传统的50%酒精按摩,将146例卧床病人随机分为观察组(活络油预防压疮)78例,对照组(50%酒精预防压疮)68例,2组均按摩卧床病人受压部位,每日3~6次,按制定标准进行观察。结果活络油和50%酒精预防压疮的效果经2χ检验,P<0.01有显著性差异;活络油和50%酒精预防压疮的不良反应经统计学处理,P<0.01,有显著性差异。结论活络油用于预防压疮效果显著,操作简便,成本较低,不良反应少。     

海豹油对家兔血脂、肝脂和心脂的影响

为研究海豹油对脂类代谢的影响，采用喂饲高胆固醇和猪油的方法建立家兔高脂模型，实验组加喂海豹油，每天2g／kg，喂养8周。结果发现，海豹油可明显降低血清总胆固醇和甘油三酯，升高高密度脂蛋白胆固醇，减少胆固醇在肝脏和心脏的蓄积。提示海豹油对心血管疾病和脂肪肝具有一定的防治作用。     

The effect of isolated soy protein adjunctive with flaxseed oil on markers of inflammation,oxidative stress,acute phase proteins,and wound healing of burn patients; a randomized clinical trial

Introduction

The objective was to determine the effect of isolated soy protein (ISP) and flaxseed oil (FO) on inflammatory and oxidative stress indices, acute phase proteins, and wound healing of burn patients.

Evaluating the efficacy of extracted squalene from seed oil in the form of microemulsion for the treatment of COVID-19: A clinical study

This study investigates the effect of the nanostructure of squalene in the form of microemulsion on COVID-19 patients. In this blinded clinical trial, a comparison was made between the efficacy of squalene treatment and controls. A total of 30 COVID-19 patients admitted to the emergency department, and the infection ward was equally allocated to case (n = 15) and control (n = 15) groups according to their age and underlying diseases. The baseline characteristics of subjects, including age, gender, time of treatment onset, underlying condition, white blood cells count, and lymphocyte count were similar (p < 0.05). Baseline laboratory tests and computed tomography (CT) scans were performed for the study groups. The treatment group received 5 mg of intravenous squalene twice a day and standard treatment for 6 days, while controls received only standard treatment. After 6 days of treatment, clinical and CT scan changes were evaluated and compared in intervention and control groups. The need for oxygen therapy (p = 0.020), 2 days of no fever (p = 0.025), cough alleviation (p = 0.010), and lung high-resolution computed tomography improvement (p = 0.033) were significantly different between cases and controls within 7 days of admission. No adverse effects were observed in the treatment group. Our data suggest that squalene could be considered as a potential treatment for COVID-19, and further studies are required to confirm the results.     

口服碘油丸对甲状腺自身抗体的影响

观察了山东省重度缺碘病区人群服用４００ｍｇ碘油前后的甲状腺自身抗体水平。服药前甲状腺自身抗体ＴｍＡｂ和ＴｇＡｂ均阴性，而服药一年、一年半和二年后分别出现５、６、１０例抗体阳性患者；服药后的ＴｍＡｂ、ＴｇＡｂ水平均明显高于服药前。提示服用碘油丸很可能会影响甲状腺自身抗体而诱发甲状腺自身免疫性疾病，应引起重视。     

Targeted GC-MS analysis of firefighters’ exhaled breath: Exploring biomarker response at the individual level

Biomarker measurements can provide unambiguous evidence of environmental exposures as well as the resultant biological responses. Firefighters have a high rate of occupational cancer incidence, which has been proposed to be linked in part to their increased environmental exposure to byproducts of combustion and contaminants produced during fire responses. In this article, the uptake and elimination of targeted volatile organic compounds were investigated by collecting the exhaled breath of firefighters on sorbent tubes before and after controlled structure burns and analyzing samples using automated thermal desorption-gas chromatography (ATD-GC/MS). Volatile organic compounds exposure was assessed by grouping the data according to firefighting job positions as well as visualizing the data at the level of the individual firefighter to determine which individuals had expected exposure responses. When data were assessed at the group level, benzene concentrations were found to be elevated post-exposure in both fire attack, victim search, and outside ventilation firefighting positions. However, the results of the data analysis at the individual level indicate that certain firefighters may be more susceptible to post-exposure volatile organic compounds increases than others, and this should be considered when assessing the effectiveness of firefighting protective gear. Although this work focuses on firefighting activity, the results can be translated to potential human health and ecological effects from building and forest fires.     

Fish oil prevents colon cancer by modulation of structure and function of mitochondria

Cancer cells are more susceptible to metabolic perturbations due to impaired electron transport chain (ETC) that promote uncontrolled proliferation. Mitochondria play a pivotal role in bioenergetics and apoptosis, hence are considered as a promising target in tumor cell eradication. Therefore, the present study is designed to elucidate chemopreventive action of fish oil (FO) in combination with corn oil (CO) on mitochondria in colorectal cancer (CRC). Male Wistar rats were divided into groups depending on dietary regimen—Control group, FO + CO(1:1) and FO + CO(2.5:1). These groups were further subdivided depending on whether these received a weekly intraperitoneal injection of ethylenediamine tetra-acetic acid (EDTA) or N,N-dimethylhydrazine dihydrochloride (DMH) for a period of 4 weeks. The animals sacrificed 48 h and 16 weeks after EDTA/DMH treatment constituted initiation and post-initiation phase respectively. The structural and functional alterations in mitochondria were evaluated using transmission electron microscopy (TEM) and by assaying electron transport chain (ETC) enzymes. Mitochondrial lipid composition and cholesterol levels were also assessed. DMH treatment led to mitochondrial degeneration, disrupted cristae and a significant decrease in ETC complexes suggestive of metabolic reprogramming. Moreover, an increase in cholesterol and cardiolipin (CL) levels in post-initiation phase led to evasion of apoptosis. FO in both the ratios resulted in stabilization and increase in number of mitochondria, however, FO + CO(2.5:1) + DMH group also exhibited mitophagy and crystolysis alongwith altered dynamics in ETC which facilitated apoptosis. It also decreased cholesterol and CL levels to increase apoptosis. Fish oil targets mitochondria in a dose dependent manner that augments apoptosis and hence attenuates carcinogenesis.     

构造油气藏与特低—超低渗岩性油藏测井评价饱和度多学科结合方法与应用

20世纪90年代以来在构造油藏砂岩含油气层的测井饱和度综合评价及分布等方面研究取得重要成果,它也是多学科结合评价油气层的关键技术之一。文章简要阐述了压汞资料与半渗透隔板毛细管压力—岩电联测实验法计算饱和度方法,在系统研究钻井液侵入各类油层对电测井影响基础上开展的“岩石物理研究经验模型”,特别是咸水钻井液侵入校正方法,介绍了2000年以来在特低—超低渗岩性油藏油层测井饱和度综合评价方法的研究进展。     

塔里木盆地西部鸟山—古董山地区断裂构造特征分析

鸟山—古董山地区位于塔里木盆地西部,巴楚隆起与麦盖提斜坡之间,鸟山—玛南、玛扎塔格、古董山和罗斯塔格构造带在此交汇,附近还发育与之密切相关的沙陇断裂。鸟山—古董山地区的主干断裂形成于白垩纪末—古近纪初,包括鸟山、罗斯塔格和玛扎塔格白垩纪末—古近纪初冲断构造带和玛南白垩纪末—古近纪初走滑断裂带,玛南断裂是玛扎塔格构造带与鸟山和罗斯塔格构造带之间的调节断层。该期构造变形受控于拉萨地块与亚洲大陆之间的碰撞造山作用。鸟山—古董山地区的断裂构造于中新世末基本定型。因帕米尔突刺楔入于塔里木地块和卡拉库姆地块之间,在塔西南地区形成一系列走滑断裂,包括玛扎塔格—罗斯塔格中新世末走滑断裂,古董山断裂是其派生断层。白垩纪末—古近纪初是研究区构造和圈闭的关键形成期,上新世晚期—全新世早期以古近系底部膏盐层为主滑脱面的滑脱—冲断构造保护早期形成的圈闭和油气藏。鸟山和玛扎塔格构造带是研究区最有利的油气勘探区带,玛南构造带是重要的油气运移通道。     

具有重力分异现象凝析气藏地质储量计算方法——以英买力地区玉东A 凝析气藏为例

由于重力分异作用, 流体密度在构造差异较大的油气藏中, 将表现出明显的上轻下重现象, 特别在凝析气 藏中表现尤为明显。通过对塔里木英买力地区一个岩性凝析气藏不同构造部位单井气油比统计发现, 构造顶部气油比比 底部高1 倍左右, 如果按照常规储量的取值方法, 取某口井的稳定生产气油比或者多口井算术平均生产气油比代表整个 气藏, 那么凝析油储量计算结果将出现较大偏差。通过气油比与海拔埋深研究发现, 两者具有明显的线性关系。结合精 细地质模型, 利用“含烃体积权衡法” 可以较为准确计算气藏平均气油比, 从而解决以上问题。