全文获取类型
收费全文 | 58299篇 |
免费 | 3440篇 |
国内免费 | 1502篇 |
专业分类
耳鼻咽喉 | 429篇 |
儿科学 | 1020篇 |
妇产科学 | 759篇 |
基础医学 | 4628篇 |
口腔科学 | 1133篇 |
临床医学 | 5398篇 |
内科学 | 6262篇 |
皮肤病学 | 509篇 |
神经病学 | 3205篇 |
特种医学 | 1329篇 |
外国民族医学 | 6篇 |
外科学 | 5944篇 |
综合类 | 10436篇 |
现状与发展 | 1篇 |
一般理论 | 18篇 |
预防医学 | 6285篇 |
眼科学 | 1012篇 |
药学 | 4890篇 |
112篇 | |
中国医学 | 7925篇 |
肿瘤学 | 1940篇 |
出版年
2024年 | 177篇 |
2023年 | 1045篇 |
2022年 | 1822篇 |
2021年 | 2559篇 |
2020年 | 2227篇 |
2019年 | 2817篇 |
2018年 | 2300篇 |
2017年 | 1964篇 |
2016年 | 1753篇 |
2015年 | 1536篇 |
2014年 | 3625篇 |
2013年 | 3267篇 |
2012年 | 3212篇 |
2011年 | 3986篇 |
2010年 | 3593篇 |
2009年 | 2645篇 |
2008年 | 2440篇 |
2007年 | 2628篇 |
2006年 | 2440篇 |
2005年 | 2035篇 |
2004年 | 1650篇 |
2003年 | 1542篇 |
2002年 | 1052篇 |
2001年 | 942篇 |
2000年 | 775篇 |
1999年 | 707篇 |
1998年 | 575篇 |
1997年 | 552篇 |
1996年 | 441篇 |
1995年 | 507篇 |
1994年 | 473篇 |
1993年 | 360篇 |
1992年 | 350篇 |
1991年 | 305篇 |
1990年 | 252篇 |
1989年 | 250篇 |
1988年 | 250篇 |
1987年 | 205篇 |
1986年 | 200篇 |
1985年 | 432篇 |
1984年 | 426篇 |
1983年 | 347篇 |
1982年 | 369篇 |
1981年 | 366篇 |
1980年 | 356篇 |
1979年 | 315篇 |
1978年 | 279篇 |
1977年 | 250篇 |
1976年 | 198篇 |
1975年 | 122篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
111.
17β-雌二醇对子宫内膜异位症患者在位子宫内膜间质细胞β-catenin mRNA和蛋白表达的影响 总被引:2,自引:0,他引:2
目的研究17β-雌二醇(17β-E2)对子宫内膜异位症(内异症)患者在位子宫内膜间质细胞β-catenin mRNA和蛋白表达的影响,探讨Wnt/β-catenin信号通路在介导雌激素促进内异症发生发展的作用。方法体外分离培养内异症患者在位子宫内膜间质细胞。用不同浓度17β-E2处理子宫内膜间质细胞48 h;此后选用10-10mol/L 17β-E2处理子宫内膜间质细胞12、24和48 h,逆转录聚合酶链反应(RT-PCR)和免疫印迹法(Western blotting)检测17β-E2处理前后子宫内膜间质细胞β-catenin mRNA和蛋白的表达水平。同法分析雌激素受体拮抗剂ICI182,780(10-6mol/L)对17β-E2促进β-catenin mRNA和蛋白表达的影响。免疫组织化学染色观察17β-E2作用后β-catenin在子宫内膜间质细胞中的定位。结果17β-E2能明显促进内异症患者在位子宫内膜间质细胞β-catenin mRNA和蛋白的表达,并呈剂量和时间依赖性,于10-10mol/L作用48 h最明显。雌激素受体拮抗剂ICI182,780能明显抑制17β-E2对子宫内膜间质细胞β-catenin mRNA和蛋白的表达。免疫组织化学染色发现17β-E2能促进β-catenin在子宫内膜间质细胞核内的表达。结论雌激素可能通过激活Wnt/β-catenin信号通路促进内异症在位子宫内膜的异位种植。 相似文献
112.
Rehan Gul Eric Masterson 《European journal of orthopaedic surgery & traumatology : orthopedie traumatologie》2005,15(2):101-104
We present our experience over 6 years with the use of uncemented total hip arthroplasty (THA) for developmental dysplasia of the hip (DDH) with a mean follow-up of 3 years. In a 6-year period, 26 THAs were performed in 19 patients with Hartofilakidis grades 2 and 3 dislocation of the hips. Out of 19 patients, seven had bilateral dislocations. Uncemented acetabular and femoral components were used in all patients. Patients with a minimum follow-up of 1 year were included in the study. The average age at the time of surgery was 38 (range 20–69) years. Approaches used include trochanteric osteotomy in 14 (54%) patients and a lateral approach in 12 (46%) patients. In addition, subtrochanteric osteotomy was performed in four (15%) patients. A Mallory-head femoral stem was used in 15 (58%) patients; a DDH femoral stem was in nine (35%), and the S-ROM femoral prosthesis in two (8%). A Mallory head acetabular shell was used in all cases, a 22.2-mm chrome cobalt head was used in 18 (69%), and a 28-mm chrome cobalt head was used in eight (31%). The average follow-up was 3 (range 1–6) years. The Harris hip score (HHS) improved in the cohort from a mean preoperative score of 51 to a mean postoperative score of 86 (p<0.05). The mean preoperative SF36v2 score was 42 compared to postoperatively of 67(p<0.05). The complication rate was 11% with nonunion of a subtrochanteric osteotomy in one patient, dislocation in one, and trochanteric bursitis due to fracture of Dall-Miles cables in one. THA for DDH is a technically demanding procedure. This short-term follow-up of THA for DDH using uncemented implants is encouraging for arthrosis secondary to DDH. It provides better function compared to arthrodesis or excision arthroplasty, especially in young individuals. A long-term follow-up is required in order to establish the role of this management strategy. 相似文献
113.
114.
Hui-Ju Wen Ying-Chu Lin Yung-Ling Lee Yueliang Leon Guo 《Pediatric allergy and immunology》2006,17(7):489-494
High cord blood immunoglobulin E (cbIgE) is known to be associated with increased risks of atopic diseases in childhood. The relationship between genetic polymorphisms and high cbIgE has not been well documented. A cross-sectional study was conducted to assess the association between cbIgE and genetic polymorphisms of interleukin (IL)-4 -590C/T, the beta-subunit of the high-affinity receptor for IgE (FcepsilonRI-beta) E237G, lymphotoxin (LT)-alphaNcoI alleles, and tumor necrosis factor (TNF)-alpha -308G/A. A total of 320 mother-neonate pairs were recruited from four maternity hospitals from different locations of Taiwan. Cord blood was obtained and assayed for cbIgE. Polymerase chain reaction followed by restriction fragment length polymorphism was used to assess the genotypes. Three hundred pairs of mothers and neonates were included in the final analysis. Infants with IL-4 -590 C allele were found to have higher risk of elevated cbIgE (> or =0.35 IU/ml, 24.3%) (p = 0.004). After adjusting for gender, birth order, maternal age, and history of allergic disease in maternal and paternal families, odds ratios for CC and CT genotypes were 4.41 and 3.16 (95% confidence interval 0.78-22.67, and 1.66-6.13), respectively, using TT genotype as reference. The genotypes of FcepsilonRI-beta, LT-alpha, and TNF-alpha were not associated with cbIgE before or after the adjustment. Our finding suggested a significant association of cbIgE with genetic polymorphism of IL-4 -590C/T, but not with the genotypes of FcepsilonRI-beta, LT-alpha, and TNF-alpha. 相似文献
115.
腹腔镜治疗精索静脉曲张235例 总被引:14,自引:3,他引:11
目的探讨腹腔镜治疗精索静脉曲张的疗效. 方法回顾分析1993年9月~2003年7月235例经腹腔镜精索静脉高位结扎术的临床资料. 结果 235例手术均获成功,手术时间5~20 min,平均12 min.术后住院2~5 d,平均3 d.210例随访6~18个月,9例复发,复发率4.3%(9/210),不育11例术后6~12个月后其妻受孕. 结论腹腔镜精索静脉高位结扎术微创、美观、疗效好,对双侧精索静脉曲张、开放性手术后复发和有腹股沟区手术史者尤为适用. 相似文献
116.
117.
目的 探讨老年人急性阑尾炎的临床特点,更好地把握腹腔镜阑尾切除(LA)术的方法和特点。方法 回顾分析50例老年人急性阑尾炎LA的临床资料。结果 LA均获成功,患者全部治愈,无严重的并发症发生,肠功能恢复时间及住院时间均缩短。结论 老年人反应迟钝,阑尾炎进展快,易发生坏疽及穿孔,合并症多,手术风险较高,LA是安全、可行的,除个别腹膜后阑尾炎外,其余均可施行LA。 相似文献
118.
Background: Retinal pigment epithelium (RPE)lesions are predictive congenital phenotypic markersfor familial adenomatous polyposis (FAP). Thisprospective screening study aims at assessing theincidence and significance of these lesions in FAPpatients and their family members.Methods: Sixty-two members from three familiesincluding five patients with the diagnosis of FAP havebeen ophthalmologically surveyed. All RPE lesions weredocumented with fundus photography and fluoresceinangiography was performed in 13 subjects.Sigmoidoscopy and/or radiological examination wereperformed annually in 9 family members with typicalRPE lesions during 4 years to allow early diagnosis ofFAP.Results: Typical RPE lesions were present infive FAP patients and 15 family members.Telangiectatic dilatations in the retinal peripherywith small dot-like hemorrhages were detected in 6subjects from 3 families These lesions wereparticularly evident on fluorescein angiography.Annual colon analysis showed polyps in 3 out of 9subjects who were positive for RPE lesions.Conclusion: RPE lesions are valuable as aclinical marker in predicting FAP. The co-existingperipheral vascular alterations which have not beenreported before, are probably related to FAP. 相似文献
119.
A 50 year old man with a two month history of upper abdominal pain and a one month history of anorexia and weight loss, presented
with icterus and evidence of peritonitis. Laparotomy revealed biliary peritonitis which had been caused by a rupture of the
fundus of the gallbladder. The common bile duct was dilated and there was a large growth in the head of the pancreas with
multiple hepatic metastases. A cholecysto-jejunostomy and gastrojejunostomy were done and the patient had an uneventful recovery. 相似文献
120.
本文报告了10例慢性泪囊炎患者,行泪囊鼻腔吻合术后,发生吻合口阻塞,再次行泪囊鼻腔吻合术,手术治愈率100%。并就其阻塞的原因、防止方法、治疗方法进行了讨论 相似文献