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971.
Shibata H  Naito J 《Brain research》2005,1059(1):93-103
The anterior and laterodorsal thalamic nuclei provide massive projections to the anterior cingulate and frontal cortices in the rat. However, the organization of reciprocal corticothalamic projections has not yet been studied comprehensively. In the present study, we clarified the organization of anterior cingulate and frontal cortical projections to the anterior and laterodorsal thalamic nuclei, using retrograde and anterograde axonal transport methods. The anteromedial nucleus (AM) receives mainly ipsilateral projections from the prelimbic and medial orbital cortices and bilateral projections from the anterior cingulate and secondary motor cortices. The projections from the anterior cingulate cortex are organized such that the rostrocaudal axis of the AM corresponds to the rostrocaudal axis of the cortex, whereas those from the secondary motor cortex are organized such that the rostrocaudal axis of the AM corresponds to the caudorostral axis of the cortex. The ventromedial part of the anteroventral nucleus receives ipsilateral projections from the anterior cingulate cortex and bilateral projections from the secondary motor cortex, in a topographic manner similar to the projections to the AM. The ventromedial part of the laterodorsal nucleus (LD) receives ipsilateral projections from the anterior cingulate and secondary motor cortices. The projections are roughly organized such that more dorsal and ventral regions within the ventromedial LD receive projections preferentially from the anterior cingulate cortex. The difference in anterior cingulate and frontal cortical projections to the anterior and laterodorsal nuclei may suggest that each thalamic nucleus plays a different functional role in spatial memory processing.  相似文献   
972.
Prior work has demonstrated that spinal cord neurons, isolated from the brain through a spinal transection, can support learning. Spinally transected rats given legshock whenever one hindlimb is extended learn to maintain the shocked leg in a flexed position, minimizing net shock exposure. This capacity for learning is inhibited by prior exposure to an uncontrollable stimulus (e.g., intermittent tailshock). The present experiments examined whether spinal cord neurons are more vulnerable to the adverse effects of uncontrollable stimulation after spinal cord injury. Experiment 1 confirmed that uncontrollable shock inhibits subsequent learning in transected rats. Rats that received uncontrollable stimulation prior to transection did not exhibit this effect, suggesting that brain systems exert a protective effect. Experiment 2 showed that this protective effect was removed if subjects received a dorsolateral funiculus lesion prior to shock exposure. Subsequent experiments were designed to determine the identity of the neurochemical systems that protect spinal plasticity. Intrathecal application of serotonin (5-HT) or a 5-HT 1A/7 agonist (8-OH DPAT) in transected rats had a protective effect that blocked the adverse effect of uncontrollable stimulation (Experiment 3). The alpha-2 noradrenergic agonist, clonidine, also protected plasticity (Experiment 4), but this effect was linked to cross-reactivity at the 5-HT 1A receptor (Experiment 5). Microinjection of a 5HT 1A antagonist (WAY 100635) into the spinal cord before intact rats received uncontrollable stimulation blocked the brain-dependent protection of spinal cord neurons. The findings indicate that serotonergic systems normally protect spinal cord plasticity from the deleterious effects of uncontrollable stimulation.  相似文献   
973.
The present study analyzed the anatomical plasticity of serotonergic immunoreactive projections to external anal sphincter (EAS) motoneurons, and the behavioral plasticity of EAS reflexes, penile erection, and locomotion in rats with spinal contusion injury (SCI) or complete spinal cord transection (TX). Electromyographic activity of the EAS, penile erection latency, and BBB locomotor score exhibited parallel recovery over the 6-week recovery period after contusion SCI. This pattern of recovery was not observed in TX animals. While locomotor scores demonstrated a small increase after TX, erectile and anorectal function remained at abnormal levels established immediately after injury. Serotonergic immunofluorescent (5-HT-IF) staining at the lesion site identified a small number of fibers spared after SCI that may provide a substrate for functional recovery. Pixel density measurements of 5-HT-IF in the vicinity of retrogradely labeled EAS and unlabeled pudendal motoneurons necessary for penile erection provide indirect evidence of serotonergic sprouting that parallels the observed functional recovery in animals with SCI. No 5-HT-IF was detected caudal to the injury site in TX animals. These studies indicate: (1) lumbosacral eliminative and reproductive reflexes provide a valid means of studying the mechanisms of post-SCI plasticity; (2) the similar recovery curves suggest similar return of descending control, perhaps through sprouting of descending serotonergic fibers; (3) the observed deficits after TX likely represent the permanent removal of descending inhibition and reflect reorganization of segmental circuitry.  相似文献   
974.
In this paper, we argue that no valid comparison between visual representations can arise unless provision is made for three critical properties: their direction of fit, their direction of causation and the level of their conceptual content. The conceptual content in turn is a function of the level of processing. Representations arising from earlier stages of processing of visual input have very little or no conceptual content. Higher order representations get their conceptual content from the connections between visual cognition and other parts of the human cognitive system. The two other critical properties of visual representations are their mind/world direction of fit and their mind/world direction of causation. The output of the semantic processing of visual input has a full mind-to-world direction of fit and a full world-to-mind direction of causation: it visually registers the way the world is and is caused by what it represents. The output of the pragmatic processing yields information for the benefit of intentions, which clearly have a world-to-mind direction of fit and a mind-to-world direction of causation. An intention is both the representation of a goal and a cause of the transformation of a goal into a fact. These properties segregate representations specialized for perception from those specialized for action. Perception implies comparison between simultaneously represented and analyzed objects: hence, object perception presupposes the representation of spatial relationships among objects in a coordinate system independent from the perceiver. Spatial relationships carry cues for attributing meaning to an object, so that their processing is actually part of semantic processing of visual information. These considerations lead to a re-evaluation of the role of the two classical pathways of the human visual system: the ventral and the dorsal cortical pathways. The parietal lobe, which has been identified with the dorsal pathway, cannot be considered as a unitary entity with a single function. The superior parietal lobule carries visuomotor processing, a non-lateralized process. The right inferior parietal lobule contributes to the perception of spatial relationships, a process with a mind-to-world direction of fit and a world-to-mind direction of causation. Finally, the left inferior parietal lobule contributes to still another type of representation, related to visually goal-directed action, i.e., with both a world-to-mind direction of fit and a mind-to-world direction of causation.  相似文献   
975.
During locomotion we routinely make voluntary head movements, similar to those made during steering tasks, in order to scan our environment and obtain information about objects in the environment and our proximity to these objects. Given the importance that head segment orientation during locomotion has received in the recent literature, two studies were designed to investigate responses following a voluntarily generated and an unexpected, externally applied head turn. During a voluntary head turn, an efferent copy of the head movement could cancel the sensory effects of the head turn, effectively isolating the movement response to that segment. Alternatively, if the steering synergy is a part of our motor repertoire, as has been suggested, movement of the head could automatically release a steering synergy of segmental control and coordination. A unique head mounted air-jet apparatus, designed and developed at the University of Waterloo, was used for both studies to ensure that auditory stimuli and the physical presence of the apparatus on the head were similar for participants of the two experiments. During certain points in the gait cycle, this device was triggered and a short burst of compressed air (350 ms) was released to cue participants to make a voluntary head turn (Experiment 1). The same device was triggered in Experiment 2; however, in this experiment compressed air was released for a longer duration (1,500 ms) which resulted in an unexpected and quick turn of the participants head to either the left or right. In these experiments, vision was also manipulated in certain trials with liquid crystal display glasses that occluded vision for the duration of the head turn. Data from the first experiment indicates that a subset of the steering synergy previously observed is released following the voluntary head movement; however, the travel trajectory path is preserved, suggesting that sensory input resulting from the head movement is partially nullified by the central nervous system. Overall safety is ensured by maintaining the same travel path. In the second experiment, an unexpected perturbation was applied to the head during locomotion to determine how the absence of an efferent copy of the movement pattern influences the level of control over body segments during locomotion. Whole body responses similar to those observed during steering tasks were observed following application of this unexpected head perturbation. It is proposed that the CNS interprets an unexpected yaw movement of the head as a change in the frame of reference, and global modifications of the walking trajectory, similar to that observed during steering tasks, are made in the perceived new direction of travel. Collectively this work extends our understanding of how the CNS establishes a head based orientation frame for locomotion. The CNS interprets and integrates anticipated and unexpected changes in sensory information from the head segment and subsequently modifies locomotion patterns according to the perceived whole body orientation in space. The sequence of control following these head movements appears to be part of a movement repertoire that is not immutable; maintaining whole body stability during locomotion is paramount.  相似文献   
976.
In addition to the trisynaptic perforant pathway from entorhinal cortex to CA1, there are multiple direct parallel pathways between several cortical regions and CA1. These may be supposed to function cooperatively, in conjunction with the perforant pathway; but neither the functional nor anatomical organization of the extended network is well understood. In this report, we further investigate the connections between anterior inferotemporal cortex (area TE) and CA1. Injections of tracer substances demonstrate that part of the dorsal subdivision of TE sends projections to CA1, but does not receive reciprocating projections back. This contrasts with the bi-directional connections between the more ventral subdivision, TEav, and CA1, as reported by previous studies (and corroborated by tracer injections in this report). The corticohippocampal projections from dorsal TE are likely to be unimodal visual. They partially converge in the posterior portion of CA1 with connections from posterior TE and from the inferior parietal lobule, perhaps constituting a network related to visual or visuospatial processes.  相似文献   
977.
Nursing informatics is a 21st century science with great potential for improving the quality, safety, and efficiency of health care. Perinatal, neonatal, and women's health nurses have an opportunity to contribute and lead in informatics. Leaders must learn about current informatics issues from essential resources, including the literature, professional organizations, and education programs, to develop successful strategies for innovation, collaboration, and implementation. Most important, nurses must be accountable for humanizing the use of technology using a nursing model.  相似文献   
978.
Miller DM  Adams AP  Light D 《Anaesthesia》2004,59(6):600-606
Untested assumptions have been made with regard to functional dead space in facemasks, filters and breathing systems used in children for the administration of inhalation anaesthesia. Total functional dead space was measured in various combinations of this equipment applied to a spontaneous ventilation lung model with parameter settings appropriate for infants of 7-8 kg. We found that functional dead space was too large to allow for spontaneous ventilation of the lungs when a breathing filter was fitted. There was minimal relationship between size of the facemask and functional dead space; however, the provision of 22-mm female inlets to facemasks achieved proportionately less functional dead space than with 15-mm male inlets. Regardless of the apparatus used and the magnitude of the dead space, the leak induced when a poorly fitting facemask was used dramatically reduced the dead space of the breathing system - to near optimal conditions - by moving the alveolar gas elimination point to within the facemask itself.  相似文献   
979.
PURPOSE: To compare the magnetic resonance imaging (MRI)-related heating per unit of whole body averaged specific absorption rate (SAR) of a conductive implant exposed to two different 1.5-Tesla/64 MHz MR systems. MATERIALS AND METHODS: Temperature changes at the electrode contacts of a deep brain stimulation lead were measured using fluoroptic thermometry. The leads were placed in a typical surgical implant configuration within a gel-filled phantom of the human head and torso. MRI was performed using two different transmit/receive body coils on two different generation 1.5-Tesla MR systems from the same manufacturer. Temperature changes were normalized to whole body averaged SAR values and compared between the two scanners. RESULTS: Depending on the landmark location, the normalized temperature change for the implant was significantly higher on one MR system compared to the other (P < 0.001). CONCLUSION: The findings revealed marked differences across two MR systems in the level of radiofrequency (RF)-induced temperature changes per unit of whole body SAR for a conductive implant. Thus, these data suggest that using SAR to guide MR safety recommendations for neurostimulation systems or other similar implants across different MR systems is unreliable and, therefore, potentially dangerous. Better, more universal, measures are required in order to ensure patient safety.  相似文献   
980.
RATIONALE AND OBJECTIVES: To show the impact of the introduction of multi-detector computed tomography (CT) on radiologic workflow and to demonstrate how this reflects on picture archiving and communications systems (PACS) requirements. MATERIALS AND METHODS: Production measurements were obtained from different CT scanners (first two single-slice CT scanners; from December 2001 single and 4-slice CT; from April 2002 single and 16-slice CT) in number of patients from the radiologic information system. Implications on our PACS were recorded in terms of images and studies stored. Furthermore, our PACS design was made so that optimal use of 3-dimensional imaging within the radiologic workflow was possible. Finally, the number of non-diagnosed studies were recorded every day since the start of the transition to a filmless radiology department. RESULTS: This PACS design achieved a high level of integration between simple viewing and advanced 3-dimensional imaging and is optimized for handling large amounts of data. Overall increase of patients scanned with CT from January 2002-December 2003 was 54%. The number of series increased by 286% from December 2001-April 2003 and by 130% from April 2002-December 2003. From January 2002-February 2003, the number of images per patient increased from 175 to 450 (157%). Non-diagnosed studies decreased from about 100-120 before to practically zero after PACS implementation. CONCLUSION: PACS significantly increases productivity because of availability of the images and elimination of certain manual tasks. These results show that although the amount of examinations increases significantly with the introduction of MDCT, simultaneous introduction of PACS and filmless operation allows radiologists to handle the growth in workload.  相似文献   
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