突发性耳聋甲皱微循环改变及针刺的影响

目的：观察突发性耳聋患甲皱微循环改变及针刺的影响。方法：采用自身前后对照的方法。对突发性耳聋患针刺前后甲皱微循环进行记录。结果：突聋患甲皱微循环明显异常，针刺后患甲皱微循环加权积分值明显改善（P＜0．05）。结论：针刺可改善突聋甲皱微循环状态，提示针刺治疗突聋的机制可能与患外周血液循环得到改善有关。     

Histopathological findings in the inner ear of cats following stapes operation

Summary This paper presents the histopathological findings in the inner ear of cats following the stapes surgery. With the surgical technique modified by us, it is possible to diminish the chance of operative failures and offer more chances of success What is more, the suggested modification of making a small hole before perforating footplate seems to be favorable to preventing sudden decompression of the labyrinth and avoiding floating fragment of stapes footplate     

特发性突聋风险预测中关联规则的应用

目的 对特发性突聋的风险预测进行数据挖掘,并形成关联规则。方法 收集517例特发性突聋患者的临床资料,包括19项特征属性,分别为性别、年龄、季节、高血压、糖尿病、心脏病、高胆固醇血症、动脉粥样硬化、长期抽烟、酗酒、精神紧张、失眠、体质弱、长期卧床、感染、先天性畸形、创伤、肿瘤和自身免疫性疾病。将源数据库进行数据清洗后,映射为挖掘数据库;设置最小支持度为0.1,最小置信度为0.9,进行关联规则分析。结果 共形成106个强关联规则,这些强关联规则中蕴含特发性突聋与19项特征属性之间的关联关系。结论 本方法有利于将抽象的数理统计理论转变为实用的关联规则来指导疾病预防控制实践。     

听性脑干反应对突发性耳聋临床疗效及预后的评估

目的：通过回顾性分析突发性耳聋（突聋）患者听性脑干反应（ABR）的测试结果,对突聋的临床疗效和预后进行判断。方法：对300例突聋患者治疗前后进行ABR及纯音测听检查。结果：Ⅴ波异常（包括波的缺失及潜伏期延长）与ABR各波均异常者预后相同且最差,其次是Ⅰ波缺失与Ⅰ、Ⅲ波均缺失者,第三为Ⅰ波潜伏期延长与Ⅰ、Ⅲ波潜伏期均延长者,Ⅲ波异常或各波间期延长者预后相对较好。结论：ABR能够为突聋患者临床疗效及预后评价提供客观依据。     

前房穿刺减压术处理急性闭角型青光眼急性发作

目的 探讨前房穿刺减压术对处理急性闭角型青光眼急性发作的疗效。方法 对7例7眼急性闭角型青光眼急性发作患者(术前眼压平均65mmHg)在应用常规药物治疗未能有效降低眼压后,于1％丁卡因表麻下,在裂隙灯下用一次性无菌5号针头于角膜周边6°处穿刺前房,放出房水至眼球变软后退针。结果 所有病例经穿刺减压后眼压即刻降下,术后平均眼压25mmHg,角膜迅速变透明,病人症状缓解。术中病人无痛苦,未发现并发症。5例5眼穿刺后约5-8小时眼压再次升高,遂再次放液。结论 前房穿刺减压术是一种有效、安全、简单的紧急处理急性闭角型青光眼急性发作的手段,避免了大量应用常规降眼压药物可能引起的副作用,为后续治疗创造了有利的条件。房水产生过多,可能是一些患者眼压控制不良的重要原因之一。     

心脏性猝死病人心肌组织CX43和CX40的表达

目的观察心脏性猝死病人左、右心室肌及室间隔肌缝隙连接蛋白43(CX43)及缝隙连接蛋白40(CX40)的表达,探讨CX43、CX40表达与心脏性猝死的关系。方法应用免疫组化及Simple PCI图像分析系统,分析比较心脏性猝死与非心脏性猝死病人心室肌及室间隔肌CX43、CX40的表达,并用SPSS 13.0统计软件对数据进行统计分析。结果非心脏性猝死病人CX43、CX40主要表达于心肌细胞闰盘处,少数表达于细胞侧面连接及胞浆中。心脏性猝死病人CX43、CX40多数弥散于胞浆及细胞侧面连接处,表达于闰盘的数量减少。心脏性猝死病人CX43在左心室、室间隔及右心室的表达明显低于对照组(t=2.09~8.01,P均<0.05);心脏性猝死病人CX40在左心室、室间隔及右心室的表达也明显低于对照组(t=3.24~9.40,P均<0.05)。结论CX43、CX40表达部位的改变与表达数量的减少,可能与心脏性猝死有一定关系。     

New Electrocardiographic Features in Brugada Syndrome

Brugada syndrome is a genetically determined familial disease with autosomal dominant transmission and variable penetrance, conferring a predisposition to sudden cardiac death due to ventricular arrhythmias. The syndrome is characterized by a typical electrocardiographic pattern in the right precordial leads. This article will focus on the new electrocardiographic features recently agreed on by expert consensus helping to identify this infequent electrocardiographic pattern.     

The turmoil around the drug-eluting stents

Of 141 hospital survivors after intracardiac repair of tetralogy of Fallot, eight died suddenly 6–23 years later. Compared with the other 133 patients, these eight were older at operation, with higher post-repair systolic right ventricular pressure and more often complete atrioventricular block; ventricular arrhythmia was diagnosed before death in three cases. In follow-up totalling 2255 patient years, the linearized rate of sudden death was 0.35%/year. The instantaneous risk of sudden death showed continuous increase with the length of follow-up. Of 80 survivors electrocardiographically evaluated 13–26 (median 20) years postoperatively, none had complete block, but 79 had complete right bundle branch block, including seven with left anterior hemiblock. Ventricular extrasystoles were recorded in 1% at rest, in 34% during exercise and in 83% during 24-hour ambulatory monitoring, with Lown Grade ≥II in 27%. Old age and possibly presence of fibrosis and/or fibroelastosis in right ventricular outflow tract muscle correlated independently with high Lown Grade. A patient with Lown grade III died suddenly 2 years after our follow-up. Old age at repair thus was associated with increased risk of late sudden death and with frequent ventricular arrhythmia in long-term survivors.     

The prognostic value of polycomb group protein B‐cell‐specific moloney murine leukemia virus insertion site 1 in stage II colon cancer patients

The aim of this study was to investigate the prognostic value of B‐cell‐specific moloney murine leukemia virus insertion site 1 (BMI1) protein expression in primary tumors of stage II colon cancer patients. BMI1 protein expression was assessed by immunohistochemistry in a retrospective patient cohort consisting of 144 stage II colon cancer patients. BMI1 expression at the invasive front of the primary tumors correlated with mismatch repair status of the tumors. Furthermore, BMI1 expression at the luminal surface correlated with T‐stage, tumor location, and the histological subtypes of the tumors. In a univariate Cox proportional hazard analysis, no statistical significant association between risk of relapse and BMI1 protein expression at the invasive front (HR: 1.12; 95% CI 0.78–1.60; p = 0.53) or at the luminal surface of the tumor (HR: 1.06; 95% CI 0.75–1.48; p = 0.70) was found. Likewise, there was no association between 5‐year overall survival and BMI1 expression at the invasive front (HR: 1.12; 95% CI 0.80–1.56; p = 0.46) or at the luminal surface of the tumor (HR: 1.16; 95% CI 0.86–1.60; p = 0.33). In conclusion, BMI1 expression in primary tumors of stage II colon cancer patients could not predict relapse or overall survival of the patients, thus having a limited prognostic value in stage II colon cancer patients.