药品检验专业图书馆特色馆藏建设

目的 满足药检专业人员及其他专业读者的各种需求,办好药检特色专业图书馆.方法 阐述药检专业图书馆特色馆藏建设过程,介绍药检专业图书馆特色馆藏资源.结果与结论 应切实加强和完善药检图书馆特色文献资源建设,及时收藏完整的、最新的药检工作文献资料,最大限度地满足药检工作的需要.     

打造良好生态系统，提高药物创新效率

过去数十年间,生命科学与疾病基础研究取得了巨大成就,但并未有效转化为临床治疗急需的药物,药物研发的产出反而在不断下降.为了有效填补基础研究与新药研发间的知识鸿沟,更好的提升药物创新效率,急需医药科研人员、生物医药企业、政府管理部门群策群力,构建更为有序的药物创新生态系统.为实现未来10～15年创新药物产出翻番的目标,需要着重做好以下方面的工作:推动药物研发相关科学研究和应用技术的进展,建设临床研究网络、提升临床试验的效率,改善药品监管部门的管理、创新药物审评方式,加强各方沟通、降低药品审评的不确定性.     

精神专科医院职工抑郁症发病率的调查分析

目的调查近10年精神专科医院职工抑郁症发病状况,以期为今后抑郁症防控管理工作提供参考依据。方法采用回顾性病例调查,对868名被调查对象逐一查阅职工保健室职工病历记录登记,应用SPSS13.0统计软件,将结果进行分析。结果 868名精神专科医院职工近10年抑郁症发病率为0.23%。结论精神专科医院职工抑郁症发病率均低于国外和国内的抑郁症发病率。     

医生、护士、患者对PICC专项护理服务的满意度调查分析

目的调查医生、护士、患者对PICC专项护理服务的满意度。方法采用PICC专项护理服务满意度问卷分别对98名医生、149名护士、182例患者进行满意度调查。结果医生、护士、患者对PICC专项护理服务的满意度得分分别为（90．40±1．79）分、（83．20±2．17）分、（86．00±2．39）分;医生对PICC专项护理服务的满意度高于护士（P〈0．05）。结论医生、护士、患者对PICC专项护理服务的满意度均较高,说明该专项护理服务具有重要的临床实用价值。     

C-21 steroidal glycosides from Dregea sinensis

Two new C-21 steroidal glycosides, dregeosides D (1) and E (2), were isolated from the roots of Dregea sinensis. The structures of the isolated compounds were elucidated on the basis of 1D and 2D NMR spectra and HR-ESI-MS analysis. Finally, the inhibited effects of the isolated compounds on interleukin 2 receptor were evaluated by enzyme-linked immunosorbent assay.     

Two new flavone glycosides from the seeds of Impatiens balsamina L.

Two new flavone glycosides were isolated from the seeds of Impatiens balsamina L. and their structures were determined as quercetin-3-O-[α-l-rhamnose-(1 → 2)-β-d-glucopyranosyl]-5-O-β-d-glucopyranoside (1), and quercetin-3-O-[(6?-O-caffeoyl)-α-l-rhamnose-(1 → 2)-β-d-glucopyranosyl]-5-O-β-d-glucopyranoside (2) on the basis of various spectral and chemical studies.     

New flavonol glycosides and new xanthone from Polygala japonica

Three new flavonol glycosides and a new xanthone were isolated from Polygala japonica HOUTT. with eight known compounds. Their structures were identified as 1,7-dihydroxy-3,4-dimethoxy-xanthone (1), kaempferol-7,4′-dimethyl ether (2), physcion (3), guazijinxanthone (4), rhamnetin (5), polygalin A (6), 3,5,7-trihydroxy-4′-methoxy-flavone-3-O-β-d-galactopyranoside (7), 3,5,3′-trihydoxy-7,4′-dimethoxy-flavone-3-O-β-d-galactopyranoside (8), 3,5,3′,4′-tetrahydroxy-7-methoxy-flavone-3-O-β-d-galactopyranoside (9), 3,5,3′,4′-tetrahydroxy-7-methoxy-flavone-3-O-β-d-glucopyranoside (10), polygalin B (11), polygalin C (12). Among them, compound 4 is a new xanthone, and 6, 11 and 12 are new flavonol glycosides. Compounds 1, 4, 7 and 8 were tested for cytotoxic activity with MTT assays on five human tumor cell lines, K562, A549, PC-3M, HCT-8 and SHG-44. Compound 4 showed cytotoxic activity against all the five cell lines.     

Two new glycosides from the fruits of Forsythia suspense

Two new glycosides suspensaside C (1) and 2,3,5,6-tetrahydro-jacaranone-4-O-β-d-glucopyranoside (2), together with four known compounds suspensaside A (3), rengynic acid-1′-O-β-d-glucopyranoside (4), forsythoside A (5), and rengynic acid (6), were isolated from the fruits of Forsythia suspense (Thunb.) Vahl. The structures of 1 and 2 were elucidated on the basis of chemical and spectral analysis, including 1D, 2D NMR analyses and HR-ESI-MS. All isolates were tested for their cytotoxicities against five human cancer cell lines (A549, Colo-205, Hep-3B, HL60, and KB). Compound 3 exhibited cytotoxicity against HL-60, Hep-3B, and A549 cancer cell lines.