全文获取类型
收费全文 | 4480篇 |
免费 | 444篇 |
国内免费 | 117篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 421篇 |
妇产科学 | 144篇 |
基础医学 | 428篇 |
口腔科学 | 5篇 |
临床医学 | 1002篇 |
内科学 | 623篇 |
皮肤病学 | 19篇 |
神经病学 | 46篇 |
特种医学 | 121篇 |
外国民族医学 | 1篇 |
外科学 | 629篇 |
综合类 | 748篇 |
现状与发展 | 1篇 |
预防医学 | 270篇 |
眼科学 | 5篇 |
药学 | 389篇 |
3篇 | |
中国医学 | 148篇 |
肿瘤学 | 37篇 |
出版年
2024年 | 29篇 |
2023年 | 118篇 |
2022年 | 186篇 |
2021年 | 269篇 |
2020年 | 248篇 |
2019年 | 211篇 |
2018年 | 202篇 |
2017年 | 226篇 |
2016年 | 268篇 |
2015年 | 241篇 |
2014年 | 303篇 |
2013年 | 444篇 |
2012年 | 232篇 |
2011年 | 273篇 |
2010年 | 196篇 |
2009年 | 215篇 |
2008年 | 173篇 |
2007年 | 173篇 |
2006年 | 160篇 |
2005年 | 125篇 |
2004年 | 134篇 |
2003年 | 76篇 |
2002年 | 69篇 |
2001年 | 68篇 |
2000年 | 52篇 |
1999年 | 48篇 |
1998年 | 28篇 |
1997年 | 46篇 |
1996年 | 38篇 |
1995年 | 44篇 |
1994年 | 24篇 |
1993年 | 11篇 |
1992年 | 12篇 |
1991年 | 22篇 |
1990年 | 8篇 |
1989年 | 4篇 |
1988年 | 8篇 |
1987年 | 4篇 |
1986年 | 4篇 |
1985年 | 12篇 |
1984年 | 10篇 |
1983年 | 4篇 |
1982年 | 3篇 |
1981年 | 4篇 |
1980年 | 3篇 |
1979年 | 6篇 |
1978年 | 3篇 |
1977年 | 2篇 |
1975年 | 2篇 |
排序方式: 共有5041条查询结果,搜索用时 15 毫秒
81.
Temporal changes in physiological parameters of systemic inflammatory response syndrome during the three days prior to a diagnosis of sepsis: a case–control study
下载免费PDF全文
![点击此处可从《Journal of clinical nursing》网站下载免费的PDF全文](/ch/ext_images/free.gif)
HyunSoo Oh PhD RN EunKyoung Bae BSN RN SeonYoung Lim BSN RN JiHye Oh BSN RN SunYoung Han BSN RN WhaSook Seo PhD RN 《Journal of clinical nursing》2016,25(21-22):3176-3188
82.
Alberto Berardi Cecilia Rossi Maria Letizia Bacchi Reggiani Annalisa Bastelli Maria Grazia Capretti Claudio Chiossi 《The journal of maternal-fetal & neonatal medicine》2017,30(14):1739-1744
Introduction: The prevalence of maternal group-B-streptococcus (GBS) colonization and risk factors (RFs) for neonatal early-onset disease (EOD) in Europe are poorly defined. Large-scale information concerning adherence to recommendations for preventing GBS-EOD are lacking.Materials and methods: This was a 3-month retrospective area-based study including all regional deliveries ≥35 weeks' gestation (in 2012). The sensitivity, specificity, positive and negative predictive values, odds ratio and receiver operating characteristic (ROC) curve for intrapartum antibiotic prophylaxis (IAP) among full-term and preterm deliveries and prolonged membrane rupture (PROM) were calculated.Results: Among 7133 women, 259 (3.6%) were preterm (35–36 weeks' gestation). Full-term women were 6874, and 876 (12.7%) had at least 1?RF. Most women (6495) had prenatal screening and 21.4% (1390) were GBS positive.IAP was given to 2369 (33.2%) women (preterm, n?=?166; full term, n?=?2203). Compared to full-term, preterm women were less likely to receive IAP when indicated (73.2% versus 90.3%, p?0.01). Full-term women represented the largest area under the curve (AUC, 0.87). PROM showed the highest sensitivity (98.6%), but the lowest specificity (6.9%) and AUC (0.53).Conclusions: Large-scale prenatal screening and IAP are feasible. Women delivering preterm are less likely to receive IAP when indicated. Most unnecessary antibiotics are given in cases of PROM. 相似文献
83.
84.
For more than 60 years the Confidential Enquiries into Maternal Deaths triennial reports have helped build a picture of maternity care within the UK, highlighting not only our successes but failures in caring for women within the puerperal period. Despite most obstetric emergencies being well described and having clear management strategies and guidance, there continues to be substandard management with poor outcomes recorded and this has been highlighted within the latest triennium report. This article describes some common obstetric emergencies with which the anaesthetist will become involved. It emphasizes management related to some deficiencies identified in the Centre for Maternal and Child Enquiries report as well as highlighting a multidisciplinary approach throughout. Good communication between team members is paramount in all aspects of medical care, but this approach should be fostered routinely to ensure that rapid and appropriate decisions are made in a safe and timely manner. 相似文献
85.
《Expert opinion on investigational drugs》2013,22(2):159-167
Innate immune mechanisms respond rapidly to bacterial infection. A key cellular component of the innate immune response is the neutrophil, whose cytoplasmic granules contain a variety of antimicrobial proteins and peptides. Among these is the bactericidal/permeability-increasing protein (BPI), a cationic 55 kDa protein whose selective anti-infective action against Gram-negative bacteria is based on its high (nM) affinity for lipopolysaccharide (LPS, or “endotoxin”). Binding of BPI to Gram-negative bacteria results in growth inhibition, serves as an opsonin that enhances phagocytosis of bacteria and inhibits bacteria-induced inflammatory responses by blocking the interaction of LPS with host pro-inflammatory pathways. Expression of BPI appears to be developmentally regulated as human newborns apparently have lower neutrophil BPI levels than adults. BPI expression has also recently been demonstrated in human epithelial cells where it appears to be inducible by endogenous anti-inflammatory lipids (lipoxins). BPI’s potent anti-endotoxic activity against a broad range of Gram-negative bacterial pathogens is manifest in biological fluids and renders it an attractive template for pharmaceutical development. Indeed, rBPI21, an active recombinant protein derived from human BPI, has proven safe in Phase I human trials, shown promise in Phase II trials and has recently completed a Phase III trial for severe meningococcaemia with apparent benefit. Identification and evaluation of additional disease entities characterised by Gram-negative bacteraemia and/or endotoxaemia as possible targets for BPI therapy continues. 相似文献
86.
《Scandinavian cardiovascular journal : SCJ》2013,47(3):289-291
A case of infected aortic graft after abdominal aorta aneurysm resection is reported and a short review of this potential lethal complication is given. 相似文献
87.
Nelesh P. Govender Jim Todd Jeremy Nel Mervyn Mer Alan Karstaedt Cheryl Cohen for GERMS-SA 《Emerging infectious diseases》2021,27(6):1607
We determined the effect of HIV infection on deaths among persons >18 months of age with culture-confirmed candidemia at 29 sentinel hospitals in South Africa during 2012–2017. Of 1,040 case-patients with documented HIV status and in-hospital survival data, 426 (41%) were HIV-seropositive. The in-hospital case-fatality rate was 54% (228/426) for HIV-seropositive participants and 37% (230/614) for HIV-seronegative participants (crude odds ratio [OR] 1.92, 95% CI 1.50–2.47; p<0.001). After adjusting for relevant confounders (n = 907), mortality rates were 1.89 (95% CI 1.38–2.60) times higher among HIV-seropositive participants than HIV-seronegative participants (p<0.001). Compared with HIV-seronegative persons, the stratum-specific adjusted mortality OR was higher among HIV-seropositive persons not managed in intensive care units (OR 2.27, 95% CI 1.47–3.52; p<0.001) than among persons who were (OR 1.56, 95% CI 1.00–2.43; p = 0.05). Outcomes among HIV-seropositive persons with candidemia might be improved with intensive care. 相似文献
88.
89.
90.