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91.
ThedynamicdistributionofnitricoxidesynthaseinthesmallintestineofmicewithintestinalradiationsicknessWeiLichun(魏丽春);GuoYao(郭鹞)(... 相似文献
92.
SRY基因诊断在临床中的应用 总被引:1,自引:0,他引:1
应用聚合酶链式反应(PCR)扩增技术,对10例染色体核型为46,XY和1例为46,XX/46,XY的性反转、睾丸女性化、两性畸形及男性生殖器发育不良的患者进行了性别决定区(SRY)基因检测。结果表明9例46,XY和1例46,XX/46,XY患者的SRY基因存在,1例46,XY女性患者的SRY基因缺失。该结果表明能够用分子生物学技术对性反转、性发育异常的病因进行分析 相似文献
93.
本研究主要对El Tor型霍乱弧菌(Vibrio cholerae biotvpe eltor,EVC)L型的某些生物学特性如生化反应、抗生素敏感性及超微结构等进行了探讨.研究发现EVC不稳定L型的生化性状与EVC流行株的非常相似,而稳定L型则变化很大.抗生素敏感性试验显示EVC稳定L型对某些作用于细胞壁的抗生素的敏感性减弱,而对大多数作用于蛋白质合成的抗生素的敏感性增强.与流行株相比,EVC稳定L型和不稳定L型的超微结构的改变很明显.此外,本文还讨论了产生这些改变的可能机制. 相似文献
94.
膀胱肿瘤组织中端粒酶催化亚基和c-myc的表达 总被引:1,自引:0,他引:1
目的 研究膀胱肿瘤组织中端粒酶催化亚基(hTERT)和c-myc间的表达及关系。方法 采用逆转录-聚合酶链反应(RT-PCR)法对27例膀胱肿瘤组织、16例癌旁组织和16例正常膀胱粘膜同时测定hTERT和c-myc表达,分析两指标在3种组织的表达差异和相关性。结果 TCC组织hTERT和c-myc的表达阳性率分别为100.0%(27/27)和66.7%(18/27);癌旁组织两指标的阳性率均为 37.5%,而正常膀胱粘膜分别为 0和 25.0%;hTERT和c-myc两指标在膀胱肿瘤组织中的阳性表达有相关性(P<0.01)。结论 hTERT较c-myc作为TCC的诊断指标更灵敏和特异;两指标在TCC中的阳性表达具有相关性。 相似文献
95.
Akira Fukushima 《Psychiatry and clinical neurosciences》1994,48(Z1):1-4
Abstract: Historical changes in forensic psychiatric evaluation on criminal responsibility and proceedings in psychopathological findings of amphetamine psychosis are reviewed at first. The classification of amphetamine related mental disorders are proposed in 6 types. Among them, the clinical characteristics and psychopathological features of “Anxiety-situational reaction type” (Fukushima) are described. According to some reasonable grounds, offenders diagnosed as anxiety-situational reaction type should be evaluated as diminished responsibility in place of irresponsibility. Finally, two cases of murder committed under the influence of amphetamine, are reported in detail. 相似文献
96.
Chelyabinsk Medical Institute. (Presented by Academician of the Academy of Medical Sciences of the USSR A. D. Ado.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 113, No. 3, pp. 299–301, March, 1992. 相似文献
97.
98.
T. E. CEDERHOLM A. B. BERG E. K. JOHANSSON K. H. HELLSTRÖM J. E. W. PALMBLAD 《European journal of clinical investigation》1994,24(9):615-620
Abstract Essential fatty acid (FA) deficiency, which may accompany protein-energy malnutrition (PEM), has been associated with impaired inflammatory reactions. We evaluated this relationship by analysing FA profiles and delayed cutaneous hypersensitivity in 20 malnourished elderly non-cancer patients and in 20 age-matched control patients. As indicated by serum cholesterol and serum triglycerides, the lipid levels were decreased by about one-third in the subjects with PEM. In comparison with the controls, there was a reduction in the ω 3 FA (e.g. eicosapentanoate) in total serum lipids (mgl-1 ) and serum phospholipids (%) of 40% and 47%, respectively. Reductions in serum ω 6 FA (e.g. linoleate and arachidonate) levels corresponded to the drop in total FA concentrations (30%). The cutaneous hypersensitivity was impaired in 14 of the malnourished patients. The magnitude of the skin reaction was positively correlated ( P < 0·05) to the concentrations of eicosapentanoate in serum lipids and serum phospholipids, as well as to the linoleate concentration in total serum lipids. Six of the malnourished patients took part in a nutritional intervention programme for 3 months. In parallel with an improvement in the nutritional status there was a 35% increase ( P < 0·05) in the total ω 3 FA serum concentration. Negative skin tests became positive and the median skin induration enlarged threefold ( P < 0·05). Thus, deficiency of ω 3 FA might be one factor contributing to cutaneous anergy in elderly malnourished patients. 相似文献
99.
N. J. Friedman S. E. Shiff F. E. Ward R. I. Schiff R. H. Buckley 《Pediatric allergy and immunology》1991,2(3):111-116
We describe a patient with severe combined immunodeficiency and transplacental transfer of maternal T cells who received an unfractionated HLA-identical sibling bone marrow transplant without prior conditioning. He presented prior to transplantation with a dermatitis later diagnosed as mild graft versus host disease. He had a normal absolute lymphocyte count, but proliferative responses to mitogens were very low. Antigens of the noninherited maternal HLA haplotype were detected on his blood lymphocytes. After transplantation, he developed a severe reaction including fever, cutaneous erythema and hepatosplenomegaly. Lymphocytes carrying the noninherited maternal HLA haplotype disappeared from his circulation, and his unprimed mononuclear cells became spontaneously cytotoxic to maternal lymphoblasts. He subsequently developed a lymphocytosis of 69,000/mm3 , diarrhea, elevated transaminases and a worsening rash, necessitating treatment with immunosuppressive agents. Full T-cell engraftment and evidence of B-cell function later ensued and spontaneously cytotoxic lymphocytes against maternal cells disappeared by 47 days post-transplantation. We postulate that the patient's constellation of signs and symptoms after transplantation represented a combination of severe graft versus graft and mild graft versus host reactions. 相似文献
100.