全文获取类型
收费全文 | 2961篇 |
免费 | 208篇 |
国内免费 | 99篇 |
专业分类
耳鼻咽喉 | 190篇 |
儿科学 | 27篇 |
妇产科学 | 16篇 |
基础医学 | 176篇 |
口腔科学 | 49篇 |
临床医学 | 220篇 |
内科学 | 394篇 |
皮肤病学 | 72篇 |
神经病学 | 88篇 |
特种医学 | 136篇 |
外科学 | 167篇 |
综合类 | 265篇 |
预防医学 | 389篇 |
眼科学 | 15篇 |
药学 | 749篇 |
1篇 | |
中国医学 | 244篇 |
肿瘤学 | 70篇 |
出版年
2024年 | 9篇 |
2023年 | 60篇 |
2022年 | 122篇 |
2021年 | 171篇 |
2020年 | 140篇 |
2019年 | 119篇 |
2018年 | 129篇 |
2017年 | 105篇 |
2016年 | 96篇 |
2015年 | 108篇 |
2014年 | 186篇 |
2013年 | 233篇 |
2012年 | 155篇 |
2011年 | 159篇 |
2010年 | 130篇 |
2009年 | 121篇 |
2008年 | 136篇 |
2007年 | 114篇 |
2006年 | 122篇 |
2005年 | 104篇 |
2004年 | 86篇 |
2003年 | 59篇 |
2002年 | 66篇 |
2001年 | 73篇 |
2000年 | 62篇 |
1999年 | 46篇 |
1998年 | 57篇 |
1997年 | 39篇 |
1996年 | 33篇 |
1995年 | 28篇 |
1994年 | 24篇 |
1993年 | 25篇 |
1992年 | 27篇 |
1991年 | 14篇 |
1990年 | 18篇 |
1989年 | 11篇 |
1988年 | 10篇 |
1987年 | 7篇 |
1986年 | 5篇 |
1985年 | 13篇 |
1984年 | 7篇 |
1983年 | 5篇 |
1982年 | 11篇 |
1981年 | 1篇 |
1980年 | 3篇 |
1979年 | 7篇 |
1978年 | 2篇 |
1977年 | 4篇 |
1976年 | 4篇 |
1973年 | 2篇 |
排序方式: 共有3268条查询结果,搜索用时 31 毫秒
91.
Athanasios I. Zavras Gregory E. Rosenberg Jared D. Danielson Vassiliki M. Cartsos 《Journal of the American Dental Association (1939)》2013,144(9):1014-1021
BackgroundAccording to the U.S. Centers for Disease Control and Prevention, 48 percent of Americans (roughly 144 million people) used at least one prescribed medication in the preceding month; 11 percent used five or more. The authors describe the U.S. Food and Drug Administration's (FDA's) MedWatch program, the safety surveillance system for drugs and devices in the United States, and the dentist's role with regard to voluntary reporting of adverse effects (AEs). They also identify the most frequent AEs in the oral cavity as reported in the FDA Adverse Event Reporting System (FAERS).MethodsThe authors reviewed the literature regarding MedWatch, and they mined data in the FAERS public database for the 100 most commonly prescribed medications and their associated AEs.ResultsPharyngitis was the most common AE. Cough, dysgeusia and dysphagia also were common.ConclusionThe MedWatch program and its related databases contain useful information about AEs of pharmaceuticals and devices manifested in the oral cavity. Increased participation in the reporting of suspected adverse reactions will improve the national surveillance system and ultimately will protect patients' safety.Practical ImplicationsAs pharmaceutical consumption increases exponentially for a growing segment of the population, and as innovation in dental technology and devices flourishes, dentists have a distinct role in safeguarding patients' well-being. Promptly reporting AEs in the oral cavity improves quality of care and protects patients' well-being. 相似文献
92.
Tomoyuki Kono Toshiho Ohtsuki Naohisa Hosomi Ikuko Takeda Shiro Aoki Yoshimasa Sueda Kayoko Ishihara Takeshi Nakamura Takemori Yamawaki Masayasu Matsumoto 《Geriatrics & Gerontology International》2012,12(3):468-474
Aim: Although several studies have reported various causes of ischemic stroke in patients with cancer, only a few have evaluated the clinical relevance of ischemic stroke pathogenesis to cancer. The aim of the present study was to elucidate the clinical characteristics of cancer‐associated ischemic stroke. Methods: We evaluated 154 ischemic stroke patients without cancer and 57 ischemic stroke patients with cancer who had either received continuous treatment for cancer within 5 years before to the onset of ischemic stroke, or who had been diagnosed with cancer within 1 year after the onset of ischemic stroke. Cancer patients were grouped into “cancer‐associated ischemic stroke,” the “conventional ischemic stroke,” or “other.” Results: A total of 15 patients (26%) were classified into the cancer‐associated ischemic stroke in cancer patients. In univariate analysis of the cancer‐associated ischemic stroke and the others, there were significant differences in the prevalence of hypertension, hyperlipidemia and advanced cancer (clinical stage IV), and the levels of d ‐dimer, fibrin degradation product and hemoglobin. With multivariate regression analysis of those factors, the prevalence of hypertension, hyperlipidemia and advanced cancer (clinical stage IV), and the levels of d ‐dimer and fibrin degradation product remained as statistically independent factors, which were associated with cancer‐associated ischemic stroke (n = 111, χ2 = 67.21, P < 0.0001). Conclusion: In acute ischemic stroke, the cancer‐associated ischemic stroke is associated with elevated d ‐dimer and fibrin degradation products, even after controlling hypertension, hyperlipidemia and advanced cancer (clinical stage IV). Geriatr Gerontol Int 2012; 12: 468–474. 相似文献
93.
PurposeTo characterize the entire rat corneal nerve architecture, the changes that occur with aging, and its sensory, sympathetic, and parasympathetic fiber distribution.MethodsSprague-Dawley rats (aged 1 day to 2 years old) of both sexes were euthanized, and the whole corneas were immunostained with protein gene product 9.5 (PGP9.5). The specimens were double-labeled with antibodies against calcitonin gene-related peptide (CGRP) and substance P (SP) as sensory nerve markers, vasoactive intestinal peptide (VIP) as a parasympathetic nerve marker, and neuropeptide Y (NPY) and tyrosine hydroxylase (TH) as markers of sympathetic fibers. Relative nerve density positive for each antibody was assessed by computer-assisted image analysis.ResultsThick nerve trunks enter the cornea in the middle of the stroma and run towards the anterior stroma, subsequently dividing into smaller branches that penetrate upwards into the epithelium to form the subbasal nerve bundles. There was no significant difference in corneal innervation between sexes. CGRP and SP were the major sensory neuropeptides with 47.6% ± 3.5% and 34.9% ± 5.1%, respectively, of the total nerves. VIP was 18.4% ± 5.7%, and NPY and TH positive fibers took up 6.92% ± 2.66% and 2.92% ± 1.52%, respectively. Epithelial nerve density increased with age, reached full development at 5 weeks, and decreased at 120 weeks.ConclusionThis study provides a complete nerve architecture and content of components of sensory, parasympathetic, and sympathetic nerves in the rat cornea. The normal innervation pattern described here will provide an essential baseline for investigators who use the rat model for assessing corneal pathologies that involve nerve alterations. 相似文献
94.
Aron Lindqvist 《Journal of plastic surgery and hand surgery》2013,47(5):246-252
We describe the types of hand injury sustained from powered wood splitters. Information about all patients with such injuries treated at the Department of Hand Surgery, University Hospital, Uppsala, during the period 1995–2001 was collected from their records, and from written questionnaires and telephone interviews. Fourteen of the 131 patients found were below the age of 15. There was no change in the annual injury rate for inpatients. Wedge splitters caused 82% and screw splitters 18% of all injuries. The part of the hand most often injured by screw splitters was the metacarpus and by wedge splitters the index finger. Screw splitters caused palmar perforation, avulsion of the thumb, and shredding injuries. Traumatic amputation and devascularising injuries were also common. Hand injury from powered wood splitters is an important and continuing problem. Most injuries are caused by wedge splitters, injuries caused by screw splitters differ from those caused by wedge splitters. Preventive measures are needed and should include keeping children away from splitters. Further research to facilitate prevention is warranted. 相似文献
95.
Takeshi Wada Satoshi Gando Asumi Mizugaki Yuichiro Yanagida Subrina Jesmin Hiroyuki Yokota Masahiro Ieko 《Thrombosis research》2013
Introduction
Post-cardiac arrest syndrome (PCAS) is often associated with disseminated intravascular coagulation (DIC), thus leading to the development of multiple organ dysfunction syndrome (MODS). The aim of this study was to examine the pathophysiological relationships between coagulation, fibrinolysis and fibrinolytic shutdown by evaluating the levels of coagulofibrinolytic markers, including soluble fibrin, thrombin-activatable fibrinolysis inhibitor (TAFI), tissue plasminogen activator-plasminogen activator inhibitor-1 complex (tPAIC), plasmin-alpha2 plasmin inhibitor complex (PPIC), neutrophil elastase and fibrin degradation product by neutrophil elastase (EXDP).Materials and Methods
Fifty-two resuscitated patients were divided into two groups: 22 DIC and 30 non-DIC patients.Results
The levels of soluble fibrin, PPIC, tPAIC, EXDP and neutrophil elastase in the DIC patients with PCAS were significantly higher than those observed in the non-DIC patients. The values of the tPAIC and JAAM DIC scores were found to be independent predictors of increased SOFA scores in the DIC patients. The MODS patients demonstrated significantly higher levels of soluble fibrin and tPAIC; however, the levels of TAFI and EXDP were identical between the patients with and without MODS. In addition, positive correlations were observed between the levels of tPAIC and EXDP in the patients with non-MODS; however, no correlations were observed between these markers in the MODS patients.Conclusions
Thrombin activation and fibrinolytic shutdown play important roles in the development of organ dysfunction in PCAS patients. Neutrophil elastase-mediated fibrinolysis cannot overcome the fibrinolytic shutdown that occurs in DIC patients with PCAS, thus resulting in the development of MODS. 相似文献96.
Ann Chi Yan Wong Lutz Birnbaumer Gary D. Housley 《The European journal of neuroscience》2013,37(9):1478-1486
The physiological significance of canonical transient receptor potential (TRPC) ion channels in sensory systems is rapidly emerging. Heterologous expression studies show that TRPC3 is a significant Ca2+ entry pathway, with dual activation via G protein‐coupled receptor (GPCR)–phospholipase C–diacylglycerol second messenger signaling, and through negative feedback, whereby a fall in cytosolic Ca2+ releases Ca2+–calmodulin channel block. We hypothesised that the latter process contributes to cochlear hair cell cytosolic Ca2+ homeostasis. Confocal microfluorimetry with the Ca2+ indicator Fluo‐4 acetoxymethylester showed that, when cytosolic Ca2+ was depleted, Ca2+ re‐entry was significantly impaired in mature TRPC3?/? inner and outer hair cells. The impact of this disrupted Ca2+ homeostasis on sound transduction was assessed with the use of distortion product otoacoustic emissions (DPOAEs), which constitute a direct measure of the outer hair cell transduction that underlies hearing sensitivity and frequency selectivity. TRPC3?/? mice showed significantly stronger DPOAE (2f1 ? f2) growth functions than wild‐type (WT) littermates within the frequency range of best hearing acuity. This translated to hyperacusis (decreased threshold) measured by the auditory brainstem response (ABR). TRPC3?/? and WT mice did not differ in the levels of temporary and permanent threshold shift arising from noise exposure, indicating that potential GPCR signaling via TRPC3 is not pronounced. Overall, these data suggest that the Ca2+ set‐point in the hair cell, and hence membrane conductance, is modulated by TRPC3s through their function as a negative feedback‐regulated Ca2+ entry pathway. This TPRC3‐regulated Ca2+ homeostasis shapes the sound transduction input–output function and auditory neurotransmission. 相似文献
97.
98.
Mélanie Guesnier-Dopagne Louis Boyer Bruno Pereira Joël Guersen Pascal Motreff Michel D’Incan 《Journal of vascular and interventional radiology : JVIR》2019,30(5):692-698.e13
PurposeTo assess the incidence and risk factors for chronic radiodermatitis after fluoroscopically guided interventions (FGIs) in high-risk patients.Materials and MethodsBetween 2010 and 2016, of 55,782 patients who underwent FGIs, 359 had a risk procedure for skin injury (maximal skin dose > 3 Gy, air kerma > 5 Gy, dose area product [DAP] > 500 Gy.cm2, or fluoroscopy time > 60 minutes). Ninety-one of these patients were examined by a dermatologist for radiodermatitis (median time after procedure, 31.2 months [95% confidence interval, 14.2–50.7]). In each case, the clinical features and topography of the skin lesions were recorded and their incidence calculated. The characteristics of the patients and of the FGIs were tested as risk factors.ResultsEight patients (8.8%) had chronic radiodermatitis; 19 (20.9%) had acute radiodermatitis. Body mass index, DAP value, and air kerma were the only risk factors identified.ConclusionsThis study shows that chronic radiodermatitis may be considered a frequent side effect in an at-risk population. The lesions are commonly benign, but extensive sclerosis can occur. Patients should be better informed about the side effects and offered a skin exam periodically. 相似文献
99.
EMA于2017年8月发布了"公认和传统草药产品申请上市许可或注册的非临床文件的指导原则(草案)"。该指导原则指出传统和公认的草药物质或制剂,在获得人体充分而详实经验的情况下,单次给药和重复给药毒性、毒代动力学研究、免疫毒性以及局部耐受性试验是不必要的;而其生殖毒性、遗传毒性和致癌性,如果发表的文献不能用或不足,附加非临床试验是必要的。详细介绍该指导原则主要内容,以期对拟在欧盟上市的中草药产品有所帮助,也对我国草药监管有所启发。 相似文献
100.
Zierhut ML Gardner JC Spilker ME Sharp JT Vicini P 《Annals of biomedical engineering》2007,35(5):781-795
In recent years, development of rheumatoid arthritis (RA) drug therapy has been more directly targeted to counteract specific
mechanisms of inflammation, and it is now believed that early aggressive treatment with disease modifying drugs is important
to inhibit future structural joint damage. The development of these new treatments has increased the need for methodologies
to assess disease activity in RA and monitor the effectiveness of drug therapy. Unlike X-ray, which shows only structural
bone damage, magnetic resonance imaging (MRI) can depict soft tissue damage and synovitis, the primary pathology of RA. Recent
studies have also indicated that MRI is sensitive to pathophysiologic changes that may predate radiographic erosions and may
predict future joint damage. In this study, we have developed a computer automated analysis technique for MR wrist images
that provides an objective measure of RA synovitis. This method applies a two-compartment pharmacokinetic model to every voxel
of a dynamic contrast-enhanced MRI (DCE-MRI) dataset and outputs resulting parametric images. The aim of this technique is
to not only objectively quantify the severity of rheumatoid synovitis, but to also locally determine where areas of serious
disease activity are situated through kinetic modeling of blood-tissue exchange. Preliminary results show good correlation
to early enhancement rate, which has previously been shown to be a useful clinical marker of RA activity. However, the use
of tracer kinetic modeling methods potentially provides more specific information regarding underlying RA physiology. This
approach could provide a useful new tool in RA patient management and could substantially improve RA therapeutic studies by
calculating objective biomarkers of the disease state. 相似文献