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131.
染料木黄酮在大鼠肝微粒体代谢的酶动力学 总被引:3,自引:1,他引:3
目的:体外研究大鼠肝微粒体中染料木黄酮代谢的酶动力学,及选择性细胞色素(CYP)酶抑制剂对其代谢的影响。方法:用大鼠肝微粒体研究染料木黄酮代谢的酶动力学,探讨CYP酶的选择性抑制剂对其代谢的影响及参与其代谢的CYP酶。结果:CYP1A2抑制剂呋喃茶碱可以显地抑制染料木黄酮代谢,使染料木黄酮的代谢速率下降。而其它CYP特异性抑制剂对染料木黄酮代谢没有明显的影响。结论:CYP1A2参与了染料木黄酮的代谢,CYP1A2的抑制剂可能会与染料木黄酮发生代谢相互作用,从而降低染料木黄酮的代谢速率。 相似文献
132.
133.
《Expert opinion on investigational drugs》2013,22(8):1829-1840
Phytoestrogens, such as the soya isoflavones genistein and daidzein, are currently being extensively investigated through both molecular, preclinical and clinical studies to determine their potential health benefits. Phytoestrogens may protect against chronic diseases such as hormone-dependent cancer (e.g., breast and prostate cancer), cardiovascular disease and osteoporosis. Investigations of phytoestrogen metabolism and bioavailability are also of great relevance. Conversion by gut microflora of daizein to its isoflavan metabolite equol, which is a more potent oestrogen and anti-oxidant, occurs only in some individuals (about 35% of subjects tested are equol excretors). This has considerable implications for daidzein bioavailability and also for cancer risk. Oxidative damage has been implicated in the development of heart disease and cancer and soya phytoestrogens have been reported to decrease plasma F2-isoprostane concentrations (biomarker for in vivo lipid peroxidation) and increase low density lipoprotein oxidation resistance. This anti-oxidant action of phytoestrogens could potentially contribute to their therapeutic efficacy. The findings from the current ongoing studies are all likely to contribute to determining the potential use of phytoestrogens as therapeutic agents. 相似文献
134.
Antiatherogenic effect of grape flavonoids in an ex vivo model 总被引:1,自引:0,他引:1
Nikitina NA Sobenin IA Myasoedova VA Korennaya VV Mel'nichenko AA Khalilov EM Orekhov AN 《Bulletin of experimental biology and medicine》2006,141(6):712-715
The effects of grape phytoestrogens on cholesterol accumulation were studied in primary culture of human blood monocytes incubated
with blood serum from postmenopausal women obtained before and 2, 4, and 6 h after single intake of plant components of grapes.
Phytoestrogens from grape seeds, pressed out grapes, and fermented grape ridges prevent cholesterol accumulation in cells
and can be regarded as prospective components for the development of natural preparations for the prevention of atherosclerosis
in postmenopausal women.
__________
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 141, No. 6, pp. 660–663, June, 2006 相似文献
135.
Jefremov V Rakitin A Mahlapuu R Zilmer K Bogdanovic N Zilmer M Karelson E 《Journal of neuroendocrinology》2008,20(5):587-596
The neuroprotective action of oestrogens and oestrogen-like compounds is in the focus of basic and clinical research. Although such action has been shown to be associated with neuronal plasma membranes, the implication of G-proteins remains to be elucidated. This study revealed that micromolar concentrations (microM) of 17beta-oestradiol and phytoestrogens, genistein and daidzein, significantly (P < 0.05) stimulate G-proteins ([(35)S]GTP gamma S binding) in the post-mortem hippocampal membranes of age-matched control women with the respective maximum effects of 28, 20 and 15% at 10 microM. In the frontocortical membranes, the stimulation of G-proteins did not differ significantly from that in hippocampal membranes. Although in the hippocampus and frontal cortex of the Alzheimer's disease (AD) women's brain, 10 microM 17beta-oestradiol produced significantly (P < 0.05) lower stimulation of G-proteins than in the control regions, stimulation by phytoestrogens revealed no remarkable decline. 17beta-Oestradiol, genistein and daidzein revealed a selective effect on various G-proteins (G(alphas), G(alpha o), G(alpha i1) or G(alpha 11) plus G(beta 1 gamma 2)) expressed in Sf9 cells. At a concentration of 10 microM, 17beta-oestradiol suppressed the H(2)O(2) and homocysteine stimulated G-proteins in the frontocortical membranes of control women to a greater extent than phytoestrogens. In AD, the suppressing effect of each compound was lower than in the controls. In the cell-free systems, micromolar concentrations of phytoestrogens scavenged OH(*) and the 2.2-diphenyl-1-picrylhydrazyl free radical (DPPH(*)) more than 17beta-oestradiol did. In the frontocortical membranes of control women, the 20 microM 17beta-oestradiol stimulated adenylate cyclase with 20% maximal effect, whereas, in AD, the effect was insignificant. Genistein did not stimulate enzyme either in control or AD frontocortical membranes. Our data confirm that the agents stimulate G-proteins in control and AD women's brains, although 17beta-oestradiol and phytoestrogens have similarities and differences in this respect. We suggest that, besides the ER-dependent one, the ER-independent antioxidant mechanism is responsible for the oestrogen stimulation of G-proteins in the brain membranes. Both of these mechanisms could be involved in the neuroprotective signalling of oestrogens that contributes to their preventive/therapeutic action against postmenopausal neurological disorders. 相似文献