人体对预先暴露-1,-0.5,0 Gz之后+Gz时的心血管反应

目的: 评价推拉动作的心血管反应性及推拉效应的发生机制. 方法: 17名健康体检现役歼击机飞行员被分别暴露于9次头高位倾斜(HUT,+1 Gz)→头低位倾斜(HDT,-1 Gz,-0.5 Gz,0 Gz)→HUT,随机顺序. 在下列条件下进行:+90° HUT 2 min,随后转为-90°, -30°, 0° HDT各30 s,随后转为+90° HUT 2 min. 床体旋转速度为45°*s-1. 间隔4 s监测一次血压(收缩压、舒张压和平均动脉压),实时监测心电图. 结果: 在HDT期间,心率和血压较基础HUT明显下降. 随后HUT,心率和血压上升,但与基础HUT比较其速度和幅度变小. -0.5 Gz和0 Gz血压较-1 Gz时明显升高. 结论: 在推拉动作小于+1 Gz时相由于颈动脉窦压力感受器的作用,导致反射性交感神经抑制、副交感神经兴奋,在其后的+Gz时相,这种交感-副交感神经兴奋性转换延迟,导致对其后+Gz的心血管反应性延迟. 这可能是推拉效应的发生机制之一.     

提高尿激酶原治疗急性心肌梗死疗效研究

尿激酶原是新一代特异性溶栓药。为进一步提高该药的安全性和有效性,本文从使用剂量、给药方案、与其他溶栓药伍用,及给药途径等方面提出了意见,供临床医生使用中参考。     

Inhibition on Telomerase Activity and Cytotoxic Effects by Cisplatin in Cultured Human Choroidal Melanoma Cells

Purpose: To study the changes of telomerase activity and cytotoxic effects by Cisplatin; cis-dichlorodiamine platinum (CDDP) in cultured human choroidal melanoma. Material and Methods: The primary cultured human choroidal melanoma cells were cultured in the presence and absence of CDDP with different concentration and time respectively. The toxic effects were evaluated by MTT and the level of telormarse was detected by PCR-ELISA assay. And the relationship between telomerase activity and cytotoxic effects were analyzed by a correlation analysis.Results: Following the increase of the concentration and the time of CDDP, gradually repressed telomerase activity was detected in cultured cells. Meanwhile, the restrain rate of the cells increased. The telomerase activity at 24h and 1μg/ml was repressed significantly compared with the control cells. However, the appearance of cell death lagged behind the decreasing of telomerase.Conclusions: CDDP is an effective telomerase inhibitor in cultured choroidal melan     

滇缅边境打洛镇6年的疟疾防治措施与效果

方法:1983—1985年在滇缅边境打洛镇采取DDT加DDVP全面滞留喷洒灭蚊,1986—1988年改用溴氰菊酯浸泡蚊帐灭蚊,并均辅以现症病人根治、重点人群保护和流动人口预防服药等综合性防治措施。结果:防治后全镇1983—1988年的年带虫发病率依次降为10.1‰、5.8‰、5.5‰、4.8‰、14.4‰和10.1‰。各年均明显较全面防治前1982年的29.0‰低。有效控制了疟疾流行。     

旅店室内空气甲醛污染对从业人员健康影响的调查报告

本文以甲醛平均浓度为０．０５８ｍｇ／ｍ３的高级宾馆为接触组和平均浓度为０．０２０ｍｇ／ｍ３的普通招待所为对照组，对其从业人员的健康状况进行调查比较，结果表明：接触组的眼、鼻、咽刺激征、呼吸道症状、头晕、疲劳感、皮肤干燥、月经不调、多汗等自觉症状阳性检出率明显高于对照组，差异具有显著性。提示，旅店业甲醛污染对从业人员健康的影响不能忽视。改善室内环境、降低空气中甲醛浓度，对于保护人体健康具有重要意义。     

Pharmacokinetics of the acetylcholinesterase oxime reactivator, HI-6, in rhesus monkeys (Macaca mulatta): effect of atropine, diazepam, and methoxyflurane anesthesia

The pharmacokinetics of the bispyridinium oxime HI-6 (CAS reg. no. 34433-31-3; 1-(((4-aminocarbonyl)pyridinio)methoxy)methyl)-2-[hydroxy i mino)methyl)- pyridinium dichloride) was investigated in rhesus monkeys (Macaca mulatta). The effects of methoxyflurane anesthesia, administration of atropine with and without diazepam were determined on the serum half-life (t1/2), clearance rate (CL), and the volume of distribution (Vd) following intramuscular (IM) administration of HI-6 (30 mg kg-1). The control t1/2, CL and Vd of HI-offere 27 min, 8.6 ml min-1 kg-1 and 0.34 l kg-1, respectively. These parameters were unaffected by the co-administration of either atropine (0.5 mg kg-1, IM) or atropine and diazepam (0.5 mg kg-1, IM + 0.2 mg kg-1 IV, respectively). Methoxyflurane anesthesia resulted in a significant increase in the HI-6 t1/2 to 61 min concomitant with a decrease in the CL to 4.1 ml min-1 kg-1 with no change in the Vd. The increase in the t1/2 of HI-6 in methoxyflurane anesthetized monkeys is probably the result of a decrease in the clearance rate and, thus, excretion of HI-6 by the kidneys.     

氧化胆固醇对动脉毒性作用的研究

将Wistar大鼠随机分成氧化胆固醇组(Och)、纯胆固醇组(Pch)和对照组,分别用氧化胆固醇混合物(250mg/kg bw/d)、纯胆固醇(250mg/kg bw/d)以及悬浮固醇用的明胶液体给大鼠灌胃,连续二天。于第二次灌胃后18小时,从大鼠尾静脉注射伊文思兰溶液,并于注射后2小时处死;取出主动脉用荧光显微分光光度术测定主动脉内膜的通透性。此外,另一部分动物在第二次灌胃后24小时处死,取出主动脉作扫描电镜的内膜观察。结果表明,Och大鼠主动脉内膜的通透性显著高于Pch组与对照组大鼠(P<0.01),而Pch组大鼠主动脉内膜的通透性和对照组无显著差异(P>0.05)。     

针刺治疗皮质下动脉硬化性脑病的临床研究

目的 :观察针刺治疗皮质下动脉硬化性脑病 (SAE)的疗效。方法 :将 5 7例SAE病人随机分为针刺组和对照组 (静点胞二磷胆碱 ) ,观察比较治疗前后的差异及组间差异。结果 :针刺组治疗前后差异显著 (P <0 .0 0 1) ,但与对照组之间无显著差异 (P >0 .0 5 )。结论 :针刺能改善SAE病人的智能 ,对老年期痴呆是有效而可靠的治疗手段之一。