Hypertrophic osteoarthropathy in primary liver rhabdomyosarcoma

Hypertrophic osteoarthropathy is a well-documented paraneoplastic phenomenon in adults. It is a rare, but important finding in children with malignant disease as it can indicate prognosis. We present a case of hypertrophic osteoarthropathy associated with primary liver rhabdomyosarcoma in a 14-year-old boy.     

Pulmonary hypertrophic osteoarthropathy in a child with late-onset agammaglobulinemia

A case of hypertrophic osteoarthropathy is described in an 8-year-old child with late-onset agammaglobulinemia, bronchiectasis and clubbing of the fingers and toes. The child presented with pain of recent onset in the legs, ankles, and knees and a diagnosis of hypertrophic osteoarthropathy was made on the basis of the radiologic findings. Therefore the differential diagnosis of bone and joint pain in agammaglobulinemic subjects must take into account hypertrophic osteoarthropathy.     

原发性肥大性骨关节病1例报告及文献复习

目的探讨原发忭肥大性骨关节病的临床表现和X线特点，以提高对该病的认识。方法报告1例原发性肥大性骨关节病的临床表现、实验室检查、X线改变，并复习相关文献。结果原发性肥大性骨关节病是一种与遗传有关的疾病，其临床表现呈多样性，与诊断及分型相关的临床表现为骨膜成骨亢进、杵状指（趾）、面部肥厚及脑回样头皮，诊断成立尚需排除继发因素，并与肢端肥大症、甲状腺性肢端肥厚、类风湿关节炎等相鉴别。结论原发性肥大性骨关节病在国内外是一种罕见的疾病，具有较典型的临床表现及影像学特征，典型者一般不难诊断，但需排除继发性及其他疾病，应提高认识，以免漏诊或误诊，并给予对症治疗。     

超声电导透射通络止痛中药外治膝骨性关节炎的临床观察

目的观察超声电导透射中药治疗膝骨性关节炎的疗效,探索中药治疗该病新的有效途径。方法选择膝骨性关节炎患者61例,随机分为超声电导药物组(A组)31例,药物热敷组(B组)30例。在保证治疗形式相同的前提下,A组应用超声电导透射通络止痛中药,B组应用传统中药骨友灵擦剂热敷进行治疗,分别对2组治疗前及治疗后2周、4周的VAS疼痛评分和膝关节功能评分进行比较。结果A组治疗2周后疼痛评分明显降低(P<0.05),B组在治疗4周后亦使疼痛评分明显降低(P<0.05);A组在治疗2周后膝关节功能评分明显降低(P<0.05),B组在治疗4周后虽然膝关节功能评分有所降低,但不明显(P>0.05)。说明超声电导药物组(A组)比药物热敷组(B组)产生镇痛效果更早,膝关节功能也逐渐恢复。结论超声电导透射通络止痛中药在治疗膝骨性关节炎方面是一种高效的中药外用方法。     

通络追风散外治退行性膝骨关节病的临床观察

目的研究通络追风散治疗退行性膝骨关节病的临床疗效。方法采用通络追风散外治退行性膝骨关节病,与电脑中频陈醋离子导入治疗进行对照,观察膝关节疼痛及功能改善情况。结果通络追风散能明显改善病情,总有效率为94.3%,能明显改善膝关节疼痛及其功能(P0.01)。结论采用通络追风散外敷治疗退行性膝骨关节病,其效果好,经济实用,值得推广。     

补中桂枝汤治疗退行性骨关节病60例临床观察

目的:观察补中桂枝汤治疗退行性骨关节病的临床疗效。方法:选退行性骨关节病患者60例,予补中桂枝汤辨证加减治疗,15天为1疗程。结果:显效48例,有效10例,无效2例,总有效率为96.7%(95%CI=88.3%~99.6%)。结论:补中桂枝汤治疗退行性骨关节病疗效满意。     

Hypertrophic osteoarthropathy of chronic inflammatory bowel disease

The case of a 14-year-old girl with painful periostitis and ulcerative colitis is reported. The association of chronic inflammatory bowel disease with osteoarthropathy is rare and has previously been reported in eight patients. The periosteal reaction found in association with inflammatory bowel disease is apparently related to a chronic disease course and may cause extreme localized pain.     

Digital clubbing, hyperhidrosis, acro-osteolysis and osteoporosis. A case resembling pachydermoperiostosis

We report a Cambodian girl with digital clubbing, profuse hyperhidrosis, and joint and leg pain and swelling. She also had extensive acro-osteolysis of distal phalanges as well as generalized osteoporosis. There was no other affected person in the family, but her parents were first cousins. Although the X-ray changes are unusual, this patient probably represents a case of pachydermoperiostosis, either occurring as a new mutation or inherited as an autosomal recessive syndrome.     

Primary hypertrophic osteoarthropathy: Another heritable disorder associated with patent ductus arteriosus

Summary Patent ductus arteriosus (PDA) is a congenital malformation that has been linked to diverse heritable and chromosomal disorders. Primary hypertrophic osteoarthropathy (HOA) is a rare heritable syndrome in which digital clubbing and periostosis become evident without any underlying illness.The objective of this article is to describe four patients with coexisting PDA and primary HOA. Surgical closure of the ductus showed no effect on the skeletal changes.Primary HOA should be included among the heritable disorders that may be associated with PDA.