The Impact of Body Mass Index on Patient Reported Outcome Measures (PROMs) and Complications Following Primary Hip Arthroplasty

Influence of BMI upon patient outcomes and complications following THA was examined across a national cohort of patients. Outcomes were compared by BMI groups (19.0–29.9 kg/m² [reference], 30.0–34.9 kg/m² [obese class I], 35.0 kg/m²+ [obese class II/III]), adjusted for case-mix differences. Obese class I patients had a significantly smaller improvement in OHS (18.9 versus 20.5, P < 0.001) and a greater risk of wound complications (odds ratio [OR] = 1.57, P = 0.006). For obese class II/III patients, there were significantly smaller improvements in OHS and EQ-5D index (P < 0.001), and greater risk of wound complications (P = 0.006), readmission (P = 0.001) and reoperation (P = 0.003). Large improvements in patient outcomes were seen irrespective of BMI, although improvements were marginally smaller and complication rates higher in obese patients.     

大同市成人高护自学考试情况的调查与分析

采用问卷形式对１２４名成人高护自学考生进行随机抽样调查。发现女性考生比例大，占９９％；其中大多数为中专学历。她们中参加自考的动机出于工作需要者占７６％，感到工作忙学习时间少而有困难者占８１．５％；认为集中辅导很有必要者占７８．３％。作者根据调查结果提出了针对性的建议。     

Renal function and outcome after heart transplantation

Objectives

To investigate whether measured glomerular filtration rate (mGFR) is a risk factor for death and/or end-stage renal disease (ESRD) after heart transplantation (HTx).

Treatment of corneal chemical alkali burns with a crosslinked thiolated hyaluronic acid film

Purpose

The study objective was to test the utilization of a crosslinked, thiolated hyaluronic acid (CMHA-S) film for treating corneal chemical burns.

基于数据的证候规范的信息研究

以讨论证候规范信息研究中数据客观化解决的思路与方法为主题,通过对基于数据的意义、数据客观化的解决方案、证候规范研究对学习技术的需求等问题的讨论,强调证候规范研究数据客观性的重要,界定中医数据客观性的意义,提出基于数据的信息研究方案,论证了采用支持向量机方法(Supporter Vector Machine,简记SVM)的优势。认为“有效”和“普遍”是中医学数据客观性的主要依据,数据的客观化是中医证候规范研究的重要前提。     

Telocytes in human fetal skeletal muscle interstitium during early myogenesis

A new peculiar stromal cell type called telocyte (TC)/CD34-positive stromal cell (i.e. cell with distinctive prolongations named telopodes) has recently been described in various tissues and organs, including the adult skeletal muscle interstitium of mammals. By forming a resident stromal three-dimensional network, TCs have been suggested to participate in different physiological processes within the skeletal muscle tissue, including homeostasis maintenance, intercellular signaling, tissue regeneration/repair and angiogenesis. Since a continuous interplay between the stromal compartment and skeletal muscle fibers seems to take place from organogenesis to aging, the present study was undertaken to investigate for the first time the presence of TCs in the human skeletal muscle during early myogenesis. In particular, we describe the morphological distribution of TCs in human fetal lower limb skeletal muscle during early stages of myogenesis (9–12 weeks of gestation). TCs were studied on tissue sections subjected to immunoperoxidase-based immunohistochemistry for CD34. Double immunofluorescence was further performed to unequivocally differentiate TCs (CD34-positive/CD31-negative) from vascular endothelial cells (CD34-positive/CD31-positive). Our findings provide evidence that stromal cells with typical morphological features and immunophenotype of TCs are present in the human skeletal muscle during early myogenesis, revealing differences in either CD34 immunopositivity or TC numbers among different gestation ages. Specifically, few TCs weakly positive for CD34 were found between 9 and 9.5 weeks. From 10 to 11.5 weeks, TCs were more numerous and strongly reactive and their telopodes formed a reticular network in close relationship with blood vessels and primary and secondary myotubes undergoing separation. On the contrary, a strong reduction in the number and immunopositivity of TCs was observed in fetal muscle sections from 12 weeks of gestation, where mature myotubes were evident. The muscle stroma showed parallel changes in amount, density and organization from 9 to 12 weeks. Moreover, blood vessels appeared particularly numerous between 10 and 11.5 weeks. Taken together, our findings suggest that TCs might play a fundamental role in the early myogenetic period, possibly guiding tissue organization and compartmentalization, as well as angiogenesis and maturation of myotubes.     

紫雪丹的质量控制

目的:建立紫雪丹的质量控制标准。方法:采用薄层色谱法对甘草、木香进行定性鉴别;采用气相色谱法对龙脑进行含量测定。结果:定性鉴别阴性无干扰,分离度高;龙脑在100μg·m L-1~800μg·m L-1(r=0.9996)范围内线性关系良好,加样回收率为100.79%,RSD为2.5%(n=6)。结论:方法可用于紫雪丹的质量控制。