两种鼻黏膜切口在鼻内镜下鼻腔泪囊吻合术中的应用

目的：比较两种鼻黏膜切口在鼻内镜下鼻腔泪囊吻合术中出血情况和术后治疗效果。

方法：回顾性研究。收集2016-06/2018-05在我院眼科确诊为慢性泪囊炎并接受鼻内镜下鼻腔泪囊吻合手术治疗的患者63例66眼。根据鼻黏膜瓣基底部位的不同分组,A组以中鼻甲腋为基底的鼻腔黏膜切口行泪囊鼻腔吻合术,B组以上颌骨线为基底的鼻腔黏膜切口行泪囊鼻腔吻合术。随访至术后6mo,比较两组患者术中出血和术后疗效。

结果：两组患者术中出血情况有差异(χ²=11.803,P<0.05),术后有效率比较无差异(82% vs 73%,P>0.05)。

结论：以中鼻甲腋为基底部的鼻腔黏膜切口,术中并发出血较多; 而以上颌骨线为基底的鼻腔黏膜切口,术中出血较少。两组患者术后疗效无差异。     

鼻内镜手术治疗鼻窦炎、鼻息肉132例临床分析

目的 回顾分析鼻内镜手术治疗慢性鼻窦炎鼻息肉的疗效及影响因素.方法 总结132例(196侧)慢性鼻窦炎鼻息肉患者的临床资料.结果 全组均随访3～12个月,治愈率72.7%,好转率21.2%,总有效率93.9%.无效6.1%.结论 鼻内镜手术治疗鼻窦炎鼻息肉刨伤小、疗效好,熟练精细的手术操作和正确的术后治疗是提高治愈率的关键.     

手术治疗腰椎间隙感染疗效分析

目的探讨病灶清除＋置管冲洗治疗腰椎间隙感染的疗效。方法对9例腰椎间隙感染患者行病灶清除＋置管冲洗。术后冲洗至全身局部症状消失、引流液清亮、引流液3次培养无细菌生长。同时静脉用两联抗生素至拔管后1～2周,再改口服抗生素巩固治疗4～6周。绝对卧床3—6个月。结果平均冲洗时间25．7d。随访6～24个月,7例痊愈,2例复发。复发的2例均有炎症向上位椎间隙扩散,其中1例用同样的方法治愈,另1例经长时间使用抗生素及消炎镇痛治疗基本治愈。结论病灶清除＋置管冲洗手术治疗腰椎间隙感染,疗效确切,可缩短疗程。     

低氧刺激鼻息肉黏膜上皮细胞炎性因子变化的初探

目的:研究低氧刺激慢性鼻窦炎伴鼻息肉（CRSwNP）与正常鼻黏膜上皮细胞炎性因子的变化与异同,探讨其在CRSwNP发病机制中的作用。方法:选择2015年6月至2018年1月在吉林大学中日联谊医院就诊的68例CRSwNP患者,其中男性36例,女性32例,年龄（45.2±12.5）岁（ xˉ±s,下同）,患者的...     

细节管理在老年留置普通硅胶胃管患者鼻饲饮食中的应用

目的 研究细节管理减少老年留置普通硅胶胃管患者鼻饲饮食后并发症、减少感染及死亡率的作用.方法 选取80例老年留置普通硅胶胃管患者,随机分为对照组40例与干预组40例,对照组患者鼻饲饮食实施常规管理,干预组患者鼻饲饮食实施管理,比较两组干预效果.结果 干预组发生胃肠道并发症6例,无堵管现象,肺部感染2例;对照组发生胃肠道...     

Innate and Adaptive Immune Responses in the Upper Respiratory Tract and the Infectivity of SARS-CoV-2

Increasing evidence shows the nasal epithelium to be the initial site of SARS-CoV-2 infection, and that early and effective immune responses in the upper respiratory tract (URT) limit and eliminate the infection in the URT, thereby preventing infection of the lower respiratory tract and the development of severe COVID-19. SARS-CoV-2 interferes with innate immunity signaling and evolves mutants that can reduce antibody-mediated immunity in the URT. Recent genetic and immunological advances in understanding innate immunity to SARS-CoV-2 in the URT, and the ability of prior infections as well as currently available injectable and potential intranasal COVID-19 vaccines to generate anamnestic adaptive immunity in the URT, are reviewed. It is suggested that the more detailed investigation of URT immune responses to all types of COVID-19 vaccines, and the development of safe and effective COVID-19 vaccines for intranasal administration, are important needs.     

中西医结合治疗膝关节骨性关节炎32例

目的:观察"输液式"关节冲洗配合中药内服外洗治疗膝关节骨性关节炎的疗效。方法:采用关节冲洗配合内服仙灵骨葆及外用中药熏洗治疗膝关节骨性关节炎32例。结果:32例经治疗总有效率为93%。结论:"输液式"关节冲洗术配合中药内服外洗治疗膝骨性关节炎创伤小、操作简便、安全可靠、疗效肯定。     

高效液相色谱法测定复方环麻喷鼻剂中主要成分的含量

目的:探讨用高效液相色谱法(HPLC法)测定复方环麻喷鼻剂中主要成分含量的方法.方法:采用Hypersil-0DS C18色谱柱(250 mm×4.6 mm,5μm),以0.02 mol/L磷酸二氢钾溶液-甲醇-10 mmol/L四丁基溴化铵溶液(60:40:5,用磷酸调节pH值至3.2)为流动相,检测波长为258 nm.结果:线性范围环丙沙星为4.8～24 μg/mL,盐酸麻黄碱为16～μg/mL;环丙沙星的平均回收率为99.4%,RSD为1.4%;盐酸麻黄碱平均回收率为101.3%,RSD为0.9%;精密度的RSD环丙沙星为0.9%,盐酸麻黄碱为1.1%.结论:HPLC法灵敏、准确,可用于复方环麻喷鼻剂的含量测定.     

A comparative study of the efficacy and safety of high-flow nasal cannula and nasal continuous positive airway pressure in neonatal respiratory distress syndrome: A protocol for systematic review and meta-analysis

Background:When it comes to preterm newborns, respiratory distress syndrome (RDS) is the most frequent respiratory condition. Despite the fact that it is well acknowledged that preterm delivery plays a significant role, the causes of lung damage are still not completely understood. In newborns with extremely low birth weight and neonatal RDS, nasal continuous positive airway pressure has been suggested as the first respiratory assistance for spontaneous breathing. In the current research, we aim to carry out a meta-analysis to assess the effectiveness and safety of high-flow nasal cannula (HFNC) and non-invasive continuous positive airway pressure (nCPAP) in patients with neonatal respiratory distress syndrome (NRDS).Methods:We intend to search the following databases: PubMed, EMBASE, Cochrane Library, Wanfang database, China National Knowledge Infrastructure (CNKI), and Google Scholar, starting from their initial publication until February 2022, to identify randomized controlled trials comparing HFNC to nCPAP in patients with NRDS. The suitable papers will be chosen by 2 writers who will work independently of one another. Using the Cochrane updated technique for risk of bias, each included article will be subjected to an independent data extraction process by the 2 writers who will then independently evaluate the risk of bias. Consequently, a third author will be asked to address any discrepancies that may arise between the writers. It will be necessary to pool the data and do a meta-analysis with the help of the RevMan 5.3 software.Results:In this study, the effectiveness and safety of HFNC will be compared with those of nCPAP in patients with NRDS.Conclusion:If the results of this research are confirmed, they may serve as a summary of the most recent data for non-invasive respiratory assistance in NRDS.Ethics and dissemination:The study will require ethical approval.Registration number:DOI 10.17605/OSF.IO/BKSQ5